The current protocol establishes a rigorous and reproducible method for quantification of morphological joint changes that accompany osteoarthritis. Application of this protocol can be valuable in monitoring disease progression and evaluating therapeutic interventions in osteoarthritis.
Pinamont, W. J., Yoshioka, N. K., Young, G. M., Karuppagounder, V., Carlson, E. L., Ahmad, A., Elbarbary, R., Kamal, F. Standardized Histomorphometric Evaluation of Osteoarthritis in a Surgical Mouse Model. J. Vis. Exp. (159), e60991, doi:10.3791/60991 (2020).