Synovial Thickness Assessment

Synovial thickness assessment is the measurement of synovial tissue within a joint to identify swelling, hypertrophy, and structural changes associated with inflammation. Using imaging methods such as musculoskeletal ultrasound or magnetic resonance imaging, clinicians visualize the synovial lining and evaluate its thickness, while Doppler ultrasound can indicate increased blood flow related to active inflammation. This assessment supports the evaluation of conditions such as rheumatoid arthritis and other inflammatory joint disorders, helping clinicians monitor disease activity, compare affected joints, and assess responses to treatment. Standardized measurements can also strengthen research on progression, prognosis, and therapeutic outcomes.

Synovial Thickness Assessment - Related Videos

Research

JoVE Journal - Biology

A 3D System for Culturing Human Articular Chondrocytes in Synovial Fluid

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Cited by 9 •

2012

A 3D system of culturing human articular chondrocytes in high levels of synovial fluid is described. Synovial fluid reflects the most natural microenvironment for articular cartilage, and can be easily obtained and stored. This system thus can be used for studying cartilage regeneration and for screening therapeutics for treating arthritis.

Establishment and Evaluation of a Sheep Model of Full-thickness Osteochondral Defect

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2026

Here, we present an integrated protocol for generating controlled osteochondral lesions in sheep knees to establish an experimental model suitable for bone and cartilage tissue regeneration studies. The protocol outlines a method for inducing a full-thickness osteochondral defect in the femoral condyle, utilizing techniques that minimize animal welfare impacts and variability in results.

Murine Full-thickness Skin Transplantation

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Cited by 41 •

2017

Murine full-thickness skin transplantation is a well-established model to study rejection in an alloimmune setting. Here, we provide a tutorial of each step involved in performing a BALB/c-->C57BL/6 full-thickness skin transplant.

Isolation and Cellular Phenotyping of Mesenchymal Stem Cells Derived from Synovial Fluid and Bone Marrow of Minipigs

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Cited by 5 •

2016

A protocol establishing mesenchymal stem cells (MSCs) isolated from the synovial fluid and bone marrow of minipigs and non-invasively collected using syringe aspiration is presented. Cellular phenotyping was performed using flow cytometry after cell isolation and in vitro cultivation of bone marrow and synovial fluids derived from MSCs.

Education

JoVE Core - Anatomy and Physiology

Structural Joints: Synovial Joints

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2025

Synovial joints are the most common type of joint in the body. A key structural characteristic for a synovial joint is the presence of a joint cavity. This fluid-filled space is where the articulating surfaces of the bones contact each other. Also, unlike fibrous or cartilaginous joints, the articulating bone surfaces at a synovial joint are not directly connected to each other with fibrous connective tissue or cartilage. This gives the bones of a synovial joint the ability to move smoothly...

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