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Biventricular Assessment of Cardiac Function and Pressure-Volume Loops by Closed-Chest Catheterization in Mice
JoVE Journal
Medicine
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JoVE Journal Medicine
Biventricular Assessment of Cardiac Function and Pressure-Volume Loops by Closed-Chest Catheterization in Mice

Biventricular Assessment of Cardiac Function and Pressure-Volume Loops by Closed-Chest Catheterization in Mice

DOI:
10.3791/61088-v

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08:21 min

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June 15, 2020

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, , ,
1Department of Medicine,Queen’s University

Chapters

  • 00:04Introduction
  • 00:37Right Carotid and Jugular Isolation
  • 02:34Right Ventricular Catheterization
  • 04:32Left Ventricular Catheterization
  • 06:21Results: PV Loop Analyses and Hemodynamic Parameter Measurements
  • 07:42Conclusion

Summary

Automatic Translation

Automatic Translation

Presented here is a protocol to assess biventricular heart function in mice by generating pressure-volume (PV) loops from the right and left ventricle in the same animal using closed chest catheterization. The focus is on the technical aspect of surgery and data acquisition.

Tags

Biventricular AssessmentCardiac FunctionPressure-volume LoopsClosed-chest CatheterizationMiceRight Carotid ArteryRight Jugular VeinRight Ventricle CatheterizationLeft VentricleSystolic FunctionDiastolic FunctionPressure WaveformCardiac Characterization

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