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Neuroscience

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A Model of Epileptogenesis in Rhinal Cortex-Hippocampus Organotypic Slice Cultures
 

A Model of Epileptogenesis in Rhinal Cortex-Hippocampus Organotypic Slice Cultures

Article doi: 10.3791/61330
March 18th, 2021

Summary March 18th, 2021

Here, we describe the preparation of rhinal cortex-hippocampus organotypic slices. Under a gradual and controlled deprivation of serum, these slices depict evolving epileptic-like events and can be considered an ex vivo model of epileptogenesis. This system represents an excellent tool for monitoring the dynamics of spontaneous activity, as well as for assessing the progression of neuroinflammatory features throughout the course of epileptogenesis.

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