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JoVE Journal
Neuroscience

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Delivery of Antibodies into the Brain Using Focused Scanning Ultrasound
 

Delivery of Antibodies into the Brain Using Focused Scanning Ultrasound

Article DOI: 10.3791/61372-v
July 18th, 2020

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Summary July 18th, 2020

Presented here is a protocol to transiently open the blood-brain barrier (BBB) either focally or throughout a mouse brain to deliver fluorescently-labeled antibodies and activate microglia. Also presented is a method to detect the delivery of antibodies and microglia activation by histology.

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