Preparation of Tunable Extracellular Matrix Microenvironments to Evaluate Schwann Cell Phenotype Specification

Zhenyuan Xu; Jacob  A. Orkwis; Greg M. Harris

doi:10.3791/61496

Journal

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Bioengineering

/

Preparation of Tunable Extracellular Matrix Microenvironments to Evaluate Schwann Cell Phenotype Specification

JoVE Journal
Bioengineering

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JoVE Journal Bioengineering

Preparation of Tunable Extracellular Matrix Microenvironments to Evaluate Schwann Cell Phenotype Specification

5,274 Views

•

07:50 min

•

June 02, 2020

DOI:

10.3791/61496-v

DOI:

10.3791/61496-v

•

07:50 min

June 02, 2020

•

5254 Views

Zhenyuan Xu¹, Jacob A. Orkwis¹, Greg M. Harris^1,2,3

¹Department of Chemical and Environmental Engineering,University of Cincinnati ²Department of Biomedical Engineering,University of Cincinnati ³Neuroscience Graduate Program,University of Cincinnati College of Medicine

Summary

This methodology aims to illustrate the mechanisms by which extracellular matrix cues such as substrate stiffness, protein composition and cell morphology regulate Schwann cell (SC) phenotype.

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Preparation of Tunable Extracellular Matrix Microenvironments to Evaluate Schwann Cell Phenotype Specification

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Summary

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