Systems Analysis of the Neuroinflammatory and Hemodynamic Response to Traumatic Brain Injury
3K views
•
Cited by 7
•
07:21 min
•
May 27th, 2022
DOI :10.3791/61504-v
May 27th, 2022
•3K views
Rowan O. Brothers*1 , Sara Bitarafan*2,3 , Alyssa F. Pybus1,3 , Levi B. Wood*1,2,3 , Erin M. Buckley*1,4,5
1Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, 2George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, 3Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, 4Department of Pediatrics, Emory University School of Medicine, 5Children's Research Scholar, Children's Healthcare of Atlanta
* These authors contributed equally
This protocol presents methods to characterize the neuroinflammatory and hemodynamic response to mild traumatic brain injury and to integrate these data as part of a multivariate systems analysis using partial least squares regression.
Chapters in this video
0:05
Introduction
0:33
Mild Traumatic Brain Injury (TBI) Weight‐Drop Model
1:20
Diffuse Correlation Spectroscopy (DCS) Cerebral Blood Flow Assessment
1:54
Multiplexed Cytokine and Phospho‐Protein Quantification
5:16
Results: Representative Traumatic Brain Injury Neuroinflammatory and Hemodynamic Response Analyses
6:37
Conclusion
Related Videos
Copyright © 2026 MyJoVE Corporation. All rights reserved.