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Systems Analysis of the Neuroinflammatory and Hemodynamic Response to Traumatic Brain Injury
JoVE Journal
Neuroscience
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JoVE Journal Neuroscience
Systems Analysis of the Neuroinflammatory and Hemodynamic Response to Traumatic Brain Injury
DOI:

07:21 min

May 27, 2022

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Chapters

  • 00:05Introduction
  • 00:33Mild Traumatic Brain Injury (TBI) Weight‐Drop Model
  • 01:20Diffuse Correlation Spectroscopy (DCS) Cerebral Blood Flow Assessment
  • 01:54Multiplexed Cytokine and Phospho‐Protein Quantification
  • 05:16Results: Representative Traumatic Brain Injury Neuroinflammatory and Hemodynamic Response Analyses
  • 06:37Conclusion

Summary

Automatic Translation

This protocol presents methods to characterize the neuroinflammatory and hemodynamic response to mild traumatic brain injury and to integrate these data as part of a multivariate systems analysis using partial least squares regression.

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