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Journal / Bioengineering / Transplantation of a 3D Bioprinted Patch in a…
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Bioengineering
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JoVE Journal Bioengineering
Transplantation of a 3D Bioprinted Patch in a Murine Model of Myocardial Infarction
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Transplantation of a 3D Bioprinted Patch in a Murine Model of Myocardial Infarction

Article DOI: 10.3791/61675-v • 07:47 min • September 26th, 2020
September 26th, 2020 •
1,2,3,4, 1,2,3
1The University of Sydney, 2University of Technology Sydney (UTS), 3The Royal North Shore Hospital, 4University Hospital of Wales

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Summary
Automatic Translation

This protocol aims to transplant a 3D bioprinted patch onto the epicardium of infarcted mice modeling heart failure. It includes details regarding anesthesia, the surgical chest opening, permanent ligation of the left anterior descending (LAD) coronary artery and application of a bioprinted patch onto the infarcted area of the heart.

Tags

3D Bioprinted Patch Myocardial Infarction Stem Cells Heart Attack Heart Failure Bioink Mouse Model Ketamine Xylazine Ventilator Thoracotomy LAD Ligation Silk Suture Remodeling Left Ventricle
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