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Bioengineering
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JoVE Journal Bioengineering
Generation of Dynamical Environmental Conditions using a High-Throughput Microfluidic Device
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Generation of Dynamical Environmental Conditions using a High-Throughput Microfluidic Device

Article DOI: 10.3791/61735-v • 14:48 min • April 17th, 2021
April 17th, 2021 •
*1, *1, 1, 1, 1
1State Key Laboratory of Cultivation Base for Photoelectric Technology and Functional Materials, State Key Laboratory of Photon-Technology in Western China Energy, Institute of Photonics and Photon-Technology, Northwest University
* These authors contributed equally

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Summary
Automatic Translation

We present a microfluidic system for high throughput studies on complex life machinery, which consists of 1500 culture units, an array of enhanced peristaltic pumps and an on-site mixing modulus. The microfluidic chip allows for the analysis of the highly complex and dynamic micro-environmental conditions in vivo.

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Generation Dynamical Environmental Conditions High-throughput Microfluidic Device Microenvironment Cytokines Ligands Concentration Stem Cell Differentiation Immune Responses Organs On Chip Platforms Chemical Signals Nanoliter Volume Milliseconds Accuracy Culture Platform Image Acquisition Dynamic Combinatorial And Sequential Signal Inputs Microfluidic Chip Peristaltic Pumps On-site Mixing Modulus Single Cells Two Dimensional Cell Populations Three Dimensional Neural Spheres Chip Design AutoCAD Software
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