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A Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model with Amputation to Control Metastasis Rate
JoVE Journal
Cancer Research
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JoVE Journal Cancer Research
A Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model with Amputation to Control Metastasis Rate
DOI:

07:31 min

May 03, 2021

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Chapters

  • 00:04Introduction
  • 01:19Intratibial Osteosarcoma (OS) Cell Injection
  • 02:41Doxorubicin Intravenous Administration
  • 03:36Hind Limb Amputation
  • 05:08Results: Representative Rat OS Imaging and Analysis
  • 06:43Conclusion

Summary

Automatic Translation

Here, a syngeneic orthotopic implantation followed by an amputation procedure of the osteosarcoma with spontaneous pulmonary metastasis that can be used for preclinical investigation of metastasis biology and development of novel therapeutics is described.

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