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Bioengineering
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Developing 3D Organized Human Cardiac Tissue within a Microfluidic Platform
 

Developing 3D Organized Human Cardiac Tissue within a Microfluidic Platform

Article DOI: 10.3791/62539-v 10:42 min June 15th, 2021
June 15th, 2021

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Summary

The goal of this protocol is to explain and demonstrate the development of a three-dimensional (3D) microfluidic model of highly aligned human cardiac tissue, composed of stem cell-derived cardiomyocytes co-cultured with cardiac fibroblasts (CFs) within a biomimetic, collagen-based hydrogel, for applications in cardiac tissue engineering, drug screening, and disease modeling.

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3D Organized Human Cardiac Tissue Microfluidic Platform Cardiovascular Disease In Vitro Models Monolayer Culture Myocardium Tissue Composition Stem Cell-derived Microfluidic Device Hydrogel Encapsulated Cardiac Cells Media Channels Nutrient Diffusion Visual Representation Protocol Human Cardiac Fibroblast Biosafety Cabinet Flask
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