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Modeling Stroke in Mice: Transient Middle Cerebral Artery Occlusion via the External Carotid Artery
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JoVE Journal Neuroscience
Modeling Stroke in Mice: Transient Middle Cerebral Artery Occlusion via the External Carotid Artery

Modeling Stroke in Mice: Transient Middle Cerebral Artery Occlusion via the External Carotid Artery

DOI:
10.3791/62573-v

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07:26 min

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May 24, 2021

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, ,
1Institute for Stroke and Dementia Research,LMU Munich, 2Munich Cluster for Systems Neurology (SyNergy)

Chapters

  • 00:04Introduction
  • 00:52Preparation of the Material and Instruments
  • 01:33Preparation of the Laser Doppler
  • 02:27Transient MCAo Model (Occlusion)
  • 04:31Transient MCAo Model (Reperfusion)
  • 06:00Results: Neuroscore and Volumetric Infarct Analysis After tMCAo
  • 06:54Conclusion

Summary

Automatic Translation

Automatic Translation

Different models of middle cerebral artery occlusion (MCAo) are used in experimental stroke research. Here, an experimental stroke model of transient MCAo via the external carotid artery (ECA) is described, which aims to mimic human stroke, in which the cerebrovascular thrombus is removed due to spontaneous clot lysis or therapy.

Tags

Keywords: Transient Middle Cerebral Artery OcclusionExternal Carotid ArteryFilament ModelStroke ModelMouseSurgical InterventionLaser DopplerCommon Carotid ArteryDissectionAnesthesiaTemperature ControlSurgical Tools

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