Name: Three-dimensional Navigation-guided, Prone, Single-position, Lateral Lumbar Interbody Fusion Technique (Video) | JoVE Journal
Uploaded: 2021-07-15T13:30:00.000+00:00
Duration: 8 min 38 s
Description: Learn a novel prone lateral lumbar interbody fusion technique using intraoperative navigation and an open Jackson table. This single-position approach enables direct posterior decompression and robust cage placement for spinal stabilization.

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5 minutes

We thank the dedicated work from our nurses and surgical technicians in making the advance of this technique a possibility.

NOTE: The protocol follows the guidelines of and was approved by the Brigham human research ethics committee.
1. Equipment and positioning
<ol>
	<li>Use an open Jackson table for the procedure. Ensure the availability of both frameless stereotactic navigation and intraoperative neuromonitoring with lower extremity electromyography (EMGs), which are critical to the success of the case. 
	&#8203;NOTE: An open Jackson table allows the abdominal viscera to fall away from the spine during the lateral approach.</li>
	<li>Place the patient in the prone position with legs extended. Pay special attention to the hip and/or thigh pads on the side that the interbody spacer will be introduced. If required, shift these pads caudally before the procedure begins if they crowd into the anticipated lateral entry point below the patient&#39;s lowest ribs.</li>
</ol>
2. Initial posterior approach and posterolateral instrumentation
<ol>
	<li>Expose the posterior elements first via a midline incision over the target levels. Open the fascia in standard fashion, and dissect the paraspinal musculature off the bony elements, including the eventual pedicle screw entry points. Next, place a spinous clamp and have the radiology technician bring in the O-arm to obtain an intraoperative computed tomography scan to allow for stereotactic navigation.</li>
	<li>Next, place pedicle screws at the appropriate levels in a standard fashion with navigation assistance. 
	&#8203;NOTE: Doing so at this step ensures that the pedicle screws are placed before the navigation is disturbed, either inadvertently during the case or intentionally by the placement of the interbody cages. Moreover, placement of the screws can aid in the lateral discectomy portion of the case.</li>
</ol>
3. Lateral approach and interbody cage placement
<ol>
	<li>Next, start the lateral approach. Using the navigation, mark a skin incision on the flank, positioning it such that it will bring the surgeon perpendicularly across the mid-point of the target disc space (or allow for multiple such trajectories if inserting interbody cages at multiple levels).
	<ol>
		<li>At this point, rotate the patient&#39;s bed away for a more comfortable working position for the surgeon (i.e., &#34;airplaning&#34;). Similarly, consider using a sitting stool to drop the surgeon&#39;s working angle to allow for a more comfortable approach (Figure 1).</li>
	</ol>
	</li>
	<li>Make a 2&#39;&#39; to 3&#39;&#39; incision in the patient&#39;s flank, parallel to the patient&#39;s ribs. Dissect through the subcutaneous fat and external oblique fascia using electrocautery. Next, dissect with a pair of Metzenbaum scissors to spread open the external oblique, internal oblique, and transverse abdominus muscles and gain access to the retroperitoneal space.</li>
	<li>Once the potential retroperitoneal space is encountered, use fingers for blunt dissection of the space to feel the peritoneal cavity pulling away through the force of gravity and then rapidly encounter the bulk of the psoas muscle overlying the spine. Feel the transverse process as a landmark posteriorly. Use fingers for further blunt dissection to separate the retroperitoneal cavity more thoroughly from the lateral spine surface, especially in the cranial-caudal direction to minimize the chance of inadvertently entering the peritoneal cavity in the subsequent steps.</li>
	<li>Next, place a table-mounted, lighted, lateral-access retractor system just superficial&#160;to the psoas muscle (Figure 2).
	<ol>
		<li>To enter the psoas, first, use a navigation-guided fenestrated probe to select an optimal entry point and approach angle into the target disc space. Then, place A K-wire through the fenestrated probe into the disc space to secure the access.</li>
		<li>Place sequential dilators over the probe superficial to the psoas muscle until finally, the table-mounted retractor system is brought in and secured.</li>
		<li>Connect the light source to the retractor blades. Then, open the retractor blades in the cranial-caudal and anterior-posterior directions to visualize the surgical area directly.</li>
	</ol>
	</li>
	<li>Next, dissect the psoas muscle under direct vision using long Panfield 4 and long Kittner dissectors to expose enough disc space to accommodate the width of the cage (generally 18 mm). If required, use EMG monitoring to monitor the lumbosacral space. 
	NOTE: Under direct vision, the lumbosacral plexus nerves traveling on the surface of the psoas muscle are easily identified and avoided to minimize injury to those nerves. Traversing the psoas in a separate step, under direct vision with the lighted retractor system, allows for greater ability to avoid damage to the lumbosacral plexus.
	<ol>
		<li>Once the disc space is fully exposed, place two pairs of pins in the cranial and caudal vertebral bodies to keep the surgical corridor through the psoas muscle open. 
		NOTE: The pins keep the psoas muscle (and the associated plexus nerves) clear of the surgical corridor, thus providing a comfortable and safe surgical environment. It eliminates the muscle creeping problem commonly encountered with the expandable tubular retractor system (Figure 3).</li>
	</ol>
	</li>
	<li>Ensure that the disc space is adequately exposed in both the cranial-caudal and the anterior-posterior dimensions. Perform an annulotomy with a #15 blade, and perform an initial discectomy using pituitary rongeurs and curettes.
	<ol>
		<li>During this step, break the annulus on the contralateral side using a navigated cobb elevator to release the space and facilitate a larger interbody cage placement and scoliosis correction when needed.
		<ol>
			<li>Insert the navigated cobb elevator into the disc space. Under the navigation guidance, advance the tip of the cobb elevator beyond the contralateral disc border and &#34;pop&#34; it through the contralateral annulus for annulus release. 
			NOTE: Due to the cobb elevator being navigated, the location of the tip of the cobb elevator can be tracked at all times. Therefore, take care not to violate the annulus on either the anterior or posterior side to protect the great vessels and the thecal sac, respectively.</li>
		</ol>
		</li>
		<li>Of note, with simultaneous access to the posterior spine while this is going on, place the pedicle screws in distraction at this time if needed. 
		NOTE: This not only facilitates entrance into particularly narrow and collapsed disc spaces but also allows for the placement of a larger interbody spacer than would be possible otherwise.</li>
	</ol>
	</li>
	<li>Afterwards, use sequentially larger navigated shavers and navigated cage trials to prepare the disc space further. Take care to avoid violating the bony endplates. Once an appropriately sized cage trial is determined, insert the corresponding interbody cage (Conduit lateral Interbody cage) with navigation guidance (Figure 4). Before inserting the cage, fill the cage with allograft bone chips or any grafting materials of the surgeon&#39;s choice.</li>
	<li>Remove the pins holding back the psoas muscle and achieve hemostasis. At this point, shift the lighted retractor system to another target level if multiple interbody cages are intended to be placed. Otherwise, remove the system and close the muscle, fascia, and skin in a layered fashion.</li>
</ol>
4. Completion of the posterior portion
<ol>
	<li>Should further posterior decompression be needed (e.g., laminectomy), perform it at this point. 
	&#8203;NOTE: This can also be performed simultaneously during some portions of the lateral procedure if a second qualified operator is available (Figure 1).</li>
	<li>Finally, place rods to connect the pedicle screws, decorticate the spine, and place a morselized bone graft in a standard fashion. Routinely place vancomycin powder in the cavity, place wound drains, and use liposomal bupivacaine in the back musculature. Perform the closure in the standard layered fashion, including muscle, fascia, subcutaneous tissues, and skin. 
	NOTE: Closure can be performed simultaneously with the closure of the lateral incision should it fit with the workflow of the individual case.</li>
</ol>

<ol><li>Ozgur, B. M., Aryan, H. E., Pimenta, L., Taylor, W. R. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Extreme+lateral+interbody+fusion+%28XLIF%29%3A+a+novel+surgical+technique+for+anterior+lumbar+interbody+fusion%5BTitle%5D)+AND+%22The+Spine+Journal%22%5BJournal%5D)">Extreme lateral interbody fusion (XLIF): a novel surgical technique for anterior lumbar interbody fusion.</a> The Spine Journal. 6 (4), 435-443 (2006).</li>
<li>Kwon, B., Kim, D. H. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Lateral+lumbar+interbody+fusion%3A+indications%2C+outcomes%2C+and+complications%5BTitle%5D)+AND+%22Journal+of+the+American+Academy+of+Orthopaedic+Surgeons%22%5BJournal%5D)">Lateral lumbar interbody fusion: indications, outcomes, and complications.</a> Journal of the American Academy of Orthopaedic Surgeons. 24 (2), 96-105 (2016).</li>
<li>Rodgers, W. B., Gerber, E. J., Patterson, J. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Intraoperative+and+early+postoperative+complications+in+extreme+lateral+interbody+fusion%3A+an+analysis+of+600+cases%5BTitle%5D)+AND+%22Spine%22%5BJournal%5D)">Intraoperative and early postoperative complications in extreme lateral interbody fusion: an analysis of 600 cases.</a> Spine. 36 (1), 26-32 (2011).</li>
<li>Pimenta, L., Turner, A. W. L., Dooley, Z. A., Parikh, R. D., Peterson, M. D. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Biomechanics+of+lateral+interbody+spacers%3A+going+wider+for+going+stiffer%5BTitle%5D)+AND+%22The+Scientific+World+Journal%22%5BJournal%5D)">Biomechanics of lateral interbody spacers: going wider for going stiffer.</a> The Scientific World Journal. 2012, 381814(2012).</li>
<li>Ploumis, A., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Biomechanical+comparison+of+anterior+lumbar+interbody+fusion+and+transforaminal+lumbar+interbody+fusion%5BTitle%5D)+AND+%22Journal+of+Spinal+Disorders+%26+Techniques%22%5BJournal%5D)">Biomechanical comparison of anterior lumbar interbody fusion and transforaminal lumbar interbody fusion.</a> Journal of Spinal Disorders & Techniques. 21 (2), 120-125 (2008).</li>
<li>Blizzard, D. J., Thomas, J. A. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((MIS+single-position+lateral+and+oblique+lateral+lumbar+interbody+fusion+and+bilateral+pedicle+screw+fixation%3A+feasibility+and+perioperative+results%5BTitle%5D)+AND+%22Spine%22%5BJournal%5D)">MIS single-position lateral and oblique lateral lumbar interbody fusion and bilateral pedicle screw fixation: feasibility and perioperative results.</a> Spine. 43 (6), 440-446 (2018).</li>
<li>Ouchida, J., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Simultaneous+single-position+lateral+interbody+fusion+and+percutaneous+pedicle+screw+fixation+using+O-arm-based+navigation+reduces+the+occupancy+time+of+the+operating+room%5BTitle%5D)+AND+%22European+Spine+Journal%22%5BJournal%5D)">Simultaneous single-position lateral interbody fusion and percutaneous pedicle screw fixation using O-arm-based navigation reduces the occupancy time of the operating room.</a> European Spine Journal. 29 (6), 1277-1286 (2020).</li>
<li>Lamartina, C., Berjano, P. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Prone+single-position+extreme+lateral+interbody+fusion+%28Pro-XLIF%29%3A+preliminary+results%5BTitle%5D)+AND+%22European+Spine+Journal%22%5BJournal%5D)">Prone single-position extreme lateral interbody fusion (Pro-XLIF): preliminary results.</a> European Spine Journal. 29, Suppl 1 6-13 (2020).</li>
<li>Quiceno, E., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Single+position+spinal+surgery+for+the+treatment+of+grade+II+spondylolisthesis%3A+A+technical+note%5BTitle%5D)+AND+%22Journal+of+Clinical+Neuroscience%22%5BJournal%5D)">Single position spinal surgery for the treatment of grade II spondylolisthesis: A technical note.</a> Journal of Clinical Neuroscience. 65, 145-147 (2019).</li>
<li>Buckland, A. J., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Single+position+circumferential+fusion+improves+operative+efficiency%2C+reduces+complications+and+length+of+stay+compared+with+traditional+circumferential+fusion%5BTitle%5D)+AND+%22The+Spine+Journal%22%5BJournal%5D)">Single position circumferential fusion improves operative efficiency, reduces complications and length of stay compared with traditional circumferential fusion.</a> The Spine Journal. , (2020).</li>
</ol>

Y.L. is a consultant for Depuy Synthes. S.E.H, S.G., K.H., N.K declare no competing financial interests.

This study provides a detailed protocol for a prone, single-position, 3D-navigation-guided lateral lumbar interbody fusion (Pro-LLIF). Pro-LLIF permits concurrent access to the anterior and posterior spine and does not require patient repositioning, unlike the two-stage OLIF or XLIF approach9. This single-position approach has been associated with decreased operative time, anesthesia time, and surgical staffing requirements, presenting physical and financial benefits8,...

First described as extreme lateral interbody fusion (XLIF) in 2006, the lateral lumbar interbody fusion approach (LLIF) utilizes a transpsoas approach to the vertebral body1. The LLIF presents several operative advantages over other traditional approaches. First, the LLIF is one of the least invasive interbody fusion approaches, minimizing perioperative tissue damage and blood loss, as well as postoperative pain and length of hospital stay2,3. The LLIF allows for the placement of larger interbody spacers, which confers a greater likelihood of fusion and greater disc height distraction4,5. 
Several LLIF protocols are currently employed, each of which presents limitations. The two-stage approach requires two patient positions for cage placement and posterior screw fixation, respectively. This protocol may increase intraoperative time and anesthetic exposure as the surgeon must wait for patient repositioning between the first and second stages of the procedure. Single-position LLIF variants have also been developed to improve the two-position process. Using a stand-alone LLIF technique forgoes the posterior component of the LLIF surgery and thus negates the need for patient repositioning. However, this technique precludes direct posterior decompression and the added stability of pedicle screw placement. Performing the entire surgery in the lateral position has also been described, but this introduces additional ergonomic challenges for the surgeon6,7. 
A prone single-position approach effectively decreases operative time, thus speeding patients' recovery. Below, the protocol for performing a prone single-position approach for simultaneous access to the anterior and posterior lumbar spine is outlined. Unlike a previously described variation of this approach, 3D navigation is employed to guide both the lateral approach and the interbody cage placement8. Finally, this article includes a case series of the first 10 patients who underwent this prone, lateral lumbar interbody fusion (Pro-LLIF) procedure at the authors' institution.

<table><tbody><tr><td>CONDUIT Lateral Lumbar Implants</td><td>DePuy Synthes</td><td></td><td>EIT Cellular Titanium Interbody</td></tr><tr><td>COUGAR LS Lateral Spreaders</td><td>DePuy Synthes</td><td></td><td>Lateral Spreaders: 6, 8, 10, 12, 16 mm</td></tr><tr><td>COUGAR LS Lateral Trials</td><td>DePuy Synthes</td><td></td><td>Parallel Trial, 18 x 6 mm</td></tr><tr><td>COUGAR LS Lateral Trials</td><td>DePuy Synthes</td><td></td><td>Lordotic Trials, 18 x 8 mm 18 x 10 mm 18 x 12 mm 18 x 14 mm</td></tr><tr><td>DePuy Synthes ATP/Lateral Discetomy Instruments</td><td>Avalign Technologies LLC</td><td></td><td></td></tr><tr><td>Dual Lead Awl Tip Taps 4.35 mm &amp;ndash; 10 mm</td><td>DePuy Synthes</td><td></td><td>Navigation Enabled Instruments used with Medtronic StealthStation Navigation System</td></tr><tr><td>EXPEDIUM 5.5 System</td><td>DePuy Synthes</td><td></td><td>with VIPER Cortical Fix Screws</td></tr><tr><td>EXPEDIUM Driver Shaft T20 5.5</td><td>DePuy Synthes</td><td></td><td>Navigation Enabled Instruments used with Medtronic StealthStation Navigation System</td></tr><tr><td>EXPEDIUM Drive Sleeve 5.5</td><td>DePuy Synthes</td><td></td><td>Navigation Enabled Instruments used with Medtronic StealthStation Navigation System</td></tr><tr><td>Phantom XL3 Lateral Access System</td><td>TeDan Surgical Innovations, LLC</td><td>Lateral Access retractor (includes dilators and LED Lightsource)</td><td></td></tr><tr><td>PIPELINE LS LATERAL Fixation Pins</td><td>DePuy Synthes</td><td></td><td></td></tr><tr><td>The R Project, R package version 4.0, MatchIt package</td><td></td><td></td><td>propensity-score matching</td></tr><tr><td>SENTIO MMG Lateral Probe</td><td>DePuy Synthes</td><td></td><td>Lateral Access Probe</td></tr><tr><td>SENTIO MMG Stim Clip</td><td>DePuy Synthes</td><td></td><td>attaches to insilated dilators, conducting triggered EMG while rotating 360 degrees</td></tr><tr><td>VIPER 2 1.45 mm Guidewire, Sharp</td><td>DePuy Synthes</td><td></td><td></td></tr></tbody></table>

three-dimensional navigation-guided, prone, single-position, lateral lumbar interbody fusion technique

Three-dimensional Navigation-guided, Prone, Single-position, Lateral Lumbar Interbody Fusion Technique

Lateral interbody fusion provides a significant biomechanical advantage over the traditional transforaminal lumbar interbody fusion due to the large implant size and optimal implant position. However, current methods for lateral interbody cage placement require either a two-staged procedure or a single lateral decubitus position that precludes surgeons from having either full access to the posterior spine for direct decompression or comfortable pedicle screw placement.
Herein is one institution's experience with 10 cases of a prone single-position approach for simultaneous access to the anterior and posterior lumbar spine. This allows both lateral lumbar interbody cage placement, direct posterior decompression, and pedicle screw placement, all in one position. Three-dimensional (3D) navigation is utilized for increased precision in both approaching the lateral spine and interbody cage placement. The traditional blind psoas muscle tubular dilation was also modified. Tubular retractors and lateral vertebral body retractor pins were used to minimize the risks to the lumbar plexus.

Cohort demographics 
Ten consecutive patients underwent the Pro-LLIF procedure from August 2020 to February 2021. The eligibility criteria for this procedure were ages 18 and older and symptomatic degenerative spondylosis with spinal instability (spondylolisthesis or degenerative scoliosis) from L2 to L5, requiring interbody fusion. Per the institution's standard of care, all patients had trialed and failed a course of conservative management. The exclusion criteria were patients excluded from operati...

The single-position, prone, lateral approach allows for both lateral lumbar interbody placement and direct posterior decompression with pedicle screw placement in one position.

Lateral interbody fusion provides a significant biomechanical advantage over the traditional transforaminal lumbar interbody fusion due to the large ...

three-dimensional-navigation-guided-prone-single-position-lateral

Research

JoVE Journal

Neuroscience

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Cone Beam Intraoperative Computed Tomography-based Image Guidance for Minimally Invasive Transforaminal Interbody Fusion

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C-arm-Free Simultaneous OLIF51 and Percutaneous Pedicle Screw Fixation in a Single Lateral Position

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Optimizing Minimally Invasive Spine Surgery: A Fully 3D CT O-Arm Navigated Workflow in MIS TLIF

Here, we present a protocol to perform full-endoscopic trans-Kambin triangle lumbar interbody fusion (KLIF). The protocol utilizes a posterolateral approach via Kambin’s triangle for safe expandable cage insertion and neural decompression while preserving dorsal facet structure and minimizing soft tissue trauma.

Full-Endoscopic Trans-Kambin Triangle Lumbar Interbody Fusion: Surgical Technique

Explants from the midbrain dopamine system and striatum are used in a collagen matrix assay for the in vitro analysis of mesostriatal and striatonigral pathway development. In this assay axonal outgrowth and guidance can be manipulated and quantified. It can also be modified for assessing other regions or molecular cues.

Dissection and Culture of Mouse Dopaminergic and Striatal Explants in Three-Dimensional Collagen Matrix Assays

Learn a novel prone lateral lumbar interbody fusion technique using intraoperative navigation and an open Jackson table. This single-position approach enables direct posterior decompression and robust cage placement for spinal stabilization.

Three-dimensional Navigation-guided, Prone, Single-position, Lateral Lumbar Interbody Fusion Technique

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