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An Intact Pericardium Ischemic Rodent Model

JoVE Journal
Medicine

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JoVE Journal Medicine

An Intact Pericardium Ischemic Rodent Model

An Intact Pericardium Ischemic Rodent Model

DOI:

10.3791/62720-v

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07:15 min

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September 02, 2021

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Ali Fatehi Hassanabad, Darrell D. Belke, Jeannine Turnbull, Jameson A. Dundas, Vishnu Vasanthan, Guoqi Teng, Paul W. M. Fedak, Justin F. Deniset²

¹Section of Cardiac Surgery, Department of Cardiac Sciences, Libin Cardiovascular Institute,Cumming School of Medicine, ²Department of Pharmacology and Physiology,University of Calgary

Chapters

00:04Introduction
00:52Mouse Surgery Preparation
03:40Cardiac Functional Assessment by Echocardiography (ECG)
04:11Fibrosis Staining of Heart Tissue
05:17Results: Assessment of Intact Pericardium Ischemic Rodent Model
06:28Conclusion

Summary

Automatic Translation

This protocol outlines the steps for inducing myocardial infarction in mice while preserving the pericardium and its contents.

Tags

Keywords: Ischemic Rodent Model Pericardial Cavity Myocardial Infarction Coronary Ligation Cardiac Repair Heart Healing Pericardium LAD Coronary Artery Suture Ligation

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