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Radiosynthesis of 1-(2-[18F]Fluoroethyl)-L-Tryptophan using a One-pot, Two-step Protocol
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Radiosynthesis of 1-(2-[18F]Fluoroethyl)-L-Tryptophan using a One-pot, Two-step Protocol

Article DOI: 10.3791/63025-v • 08:33 min • September 21st, 2021
September 21st, 2021 •
1,2, 1,2, 1,2, 2, 3, 1,2, 1,4
1Diagnostic & Research PET/MRI Center, Nemours/Alfred I. duPont Hospital for Children, 2Department of Radiology, Nemours/Alfred I. duPont Hospital for Children, 3Department of Neurology, Nemours/Alfred I. duPont Hospital for Children, 4Department of Biomedical Research, Nemours/Alfred I. duPont Hospital for Children

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Summary
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Here, we describe the radiosynthesis of 1-(2-[18F]Fluoroethyl)-L-tryptophan, a positron emission tomography imaging agent for studying tryptophan metabolism, using a one-pot, two-step strategy in a radiochemistry synthesis system with good radiochemical yields, high enantiomeric excess, and high reliability.

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Radiosynthesis 1-(2-[18F]Fluoroethyl)-L-Tryptophan One-pot Two-step Protocol Radiolabeled Tryptophan Tracer Tryptophan Metabolism Brain Disorders Epilepsy Neuropsychiatric Disorders Neuro-oncology Radiolabeling Modules F18 Fluoride Solution Radiation Exposure Rates Wipe Test Radiochemistry Synthesis System Argon Line F18 Fluoride Transfer Line Hot Cell Glass Door Lead Door Argon Supply Line QMA Light Cartridge
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