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JoVE Journal Neuroscience
Analyzing the Parkinson's Disease Mouse Model Induced by Adeno-associated Viral Vectors Encoding Human α-Synuclein
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Analyzing the Parkinson's Disease Mouse Model Induced by Adeno-associated Viral Vectors Encoding Human α-Synuclein

Article DOI: 10.3791/63313-v • 14:45 min • July 29th, 2022
July 29th, 2022 •
1, 1, 1, 1, 2, 2,3,4, 1,5
1Laboratorio de Neuroinmunología, Fundación Ciencia & Vida, 2Center for Integrative Biology, Universidad Mayor, 3FONDAP Geroscience Center for Brain Health and Metabolism, 4Buck Institute for Research on Ageing, 5Facultad de Medicina y Ciencia, Universidad San Sebastián

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Summary
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This work analyzes the vector dose and exposure time required to induce neuroinflammation, neurodegeneration, and motor impairment in this preclinical model of Parkinson's disease. These vectors encoding the human α-synuclein are delivered into the substantia nigra to recapitulate the synuclein pathology associated with Parkinson's disease.

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Parkinson's Disease Mouse Model Adeno-associated Viral Vectors Human α-synuclein Neurodegenerative Disorder Dopaminergic Neuron Nigrostriatal Pathway Protein Aggregate Synuclein Aggregates Toll-like Receptors Microglia Neural Inflammation Antigen-presenting Cells T Cells Adaptive Immune Response Stereotaxic Delivery
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