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Journal / Immunology and Infection / TNBS诱导的啮齿动物模型研究机械应力在克罗恩病中的致病作用…
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Immunology and Infection

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JoVE Journal Immunology and Infection
TNBS诱导的啮齿动物模型研究机械应力在克罗恩病中的致病作用
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TNBS诱导的啮齿动物模型研究机械应力在克罗恩病中的致病作用

Article DOI: 10.3791/63499-v • 05:08 min • March 1st, 2022
March 1st, 2022 •
*1, *1, *1, 2, 1
1Department of Internal Medicine, the University of Texas Medical Branch, 2Department of Pathology, the University of Texas Medical Branch
* These authors contributed equally

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本方案描述了啮齿动物中克罗恩病样结肠炎模型的发展。透壁炎症导致TNBS滴注部位狭窄，并且在狭窄近端的节段观察到机械性肿大。这些变化允许研究结肠炎的机械应力。

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《免疫学与感染》第181期，
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