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Journal / Medicine / 藏族小型猪射血分数保留的心力衰竭手术模型…
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藏族小型猪射血分数保留的心力衰竭手术模型
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藏族小型猪射血分数保留的心力衰竭手术模型

Article DOI: 10.3791/63526-v • 07:09 min • February 18th, 2022
February 18th, 2022 •
*1,2, *1,3, *1, *1, 2, 1, 1, 1, 1
1Guangdong Laboratory Animals Monitoring Institute, 2Department of Cardiovascular Surgery, the First Affiliated Hospital, Jinan University, 3College of Veterinary Medicine, South China Agricultural University
* These authors contributed equally

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本方案描述了使用降主动脉收缩建立射血分数保留的心力衰竭迷你猪模型的分步程序。还介绍了评估该疾病模型的心脏形态学、组织学和功能的方法。

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手术模型，心力衰竭，射血分数保留，藏族迷你猪，大型动物模型，降主动脉收缩，慢性压力超负荷，左心室，超声心动图，形态学改变，功能改变，室间隔肥厚，后壁厚度缩小，左心室扩张，左心室射血分数，心脏损伤，纤维化，炎症，心肌细胞肥大，心力衰竭标志物，分子机制
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