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Journal / Developmental Biology / Etablering af organoider fra menneskelig tand som …
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JoVE Journal Developmental Biology
Etablering af organoider fra menneskelig tand som et kraftfuldt værktøj mod mekanistisk forskning og regenerativ terapi
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Etablering af organoider fra menneskelig tand som et kraftfuldt værktøj mod mekanistisk forskning og regenerativ terapi

Article DOI: 10.3791/63671-v • 11:02 min • April 13th, 2022
April 13th, 2022 •
1, 2, 2, 1
1Laboratory of Tissue Plasticity in Health and Disease, Cluster of Stem Cell and Developmental Biology, Department of Development and Regeneration, Leuven Stem Cell Institute, KU Leuven (University of Leuven), 2Biomedical Research Institute (BIOMED), UHasselt, Hasselt University

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Vi præsenterer en protokol til udvikling af epitelorganoidkulturer startende fra menneskelig tand. Organoiderne er robust udvidelige og rekapitulerer tandens epitelstamceller, herunder deres ameloblastdifferentieringskapacitet. Den unikke organoidmodel giver et lovende værktøj til at studere human dental (stamcelle) biologi med perspektiver for tandregenerative tilgange.

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Udviklingsbiologi udgave 182
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