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JoVE Journal Bioengineering
Combining Human Organoids and Organ-on-a-Chip Technology to Model Intestinal Region-Specific Functionality
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Combining Human Organoids and Organ-on-a-Chip Technology to Model Intestinal Region-Specific Functionality

Article DOI: 10.3791/63724-v • 10:56 min • May 5th, 2022
May 5th, 2022 •
*1, *1, 1, 1, 2,3
1Emulate Inc. Boston, 2Center for Stem Cell and Organoid Medicine, Cincinnati Children’s Hospital Medical Center, 3Division of Pediatric General and Thoracic Surgery, Cincinnati Children’s Hospital Medical Center
* These authors contributed equally

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Summary
Automatic Translation

Biopsy-derived intestinal organoids and organ-on-a-chips technologies are combined into a microphysiological platform to recapitulate region-specific intestinal functionality.

Tags

Human Organoids Organ-on-a-chip Technology Intestinal Region-specific Functionality Biopsy-derived Intestinal Organoids Physiologically Relevant Intestine Chip Pharmacokinetics Drug-drug Interaction Intestinal Epithelial Barrier Dysfunction Complexity Of The Intestinal Epithelium Experimental Control Mechanical Cues Flow Distribution Biochemical Gradients Cellular And Molecular Basis Normal Gut Functions Pathological Gut Functions Pharmacodynamics Drug Candidates Inflammatory Damage Seeding Density Organoid Fragments Epithelial Barrier Development And Differentiation BMM Dissociation Solution
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