A Murine Model of Hemodialysis Access-Related Hand Dysfunction

This is the only animal model that is available to study the mechanisms responsible for dialysis access-related hand ischemia. The model provides a robust platform to examine the complex interplay between uremia and neuromuscular perturbations that result from hemodynamic changes resulting from arterial venous fistula surgery. Access-related hand dysfunction affects up to 60%of hemodialysis patients and can severely impact patient quality of life.

This model helps us understand the disability and test novel therapies. Demonstrating the procedure will be Dr.Raymond Kim, a post-doctoral researcher from our laboratory. To begin, place the anesthetized mouse in the supine position on a surgery table covered by a sterile drape, and apply the ocular lubricant to protect the eyes from drying during surgery.