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JoVE Journal Bioengineering
Fabricating Highly Open Porous Microspheres (HOPMs) via Microfluidic Technology
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Fabricating Highly Open Porous Microspheres (HOPMs) via Microfluidic Technology

Article DOI: 10.3791/63971-v • 05:21 min • May 16th, 2022
May 16th, 2022 •
1,2, 3, 1,2, 4, 1,2
1Institute of Biomaterials and Tissue Engineering, Huaqiao University, 2Fujian Provincial Key Laboratory of Biochemical Technology, Huaqiao University, 3Affiliated Dongguan Hospital, Southern Medical University, 4Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School

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Summary
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The present protocol describes the fabrication of poly(lactic-co-glycolic acid)-based highly open porous microspheres (HOPMs) via the single-emulsion formulation based facile microfluidic technology. These microspheres have potential applications in tissue engineering and drug screening.

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Fabricating Highly Open Porous Microspheres HOPMs Microfluidic Technology Protocol PLGA-based Convenience Of Packaging Cells Improved Cell Retention Minimal Invasiveness Monodispersed Particle Sizes Open Pores Interconnecting Windows Cell Retention Efficacy Minimally Invasive Microcarriers 3D Tumor Model Drug Screening Facile Tools Tissue Regeneration Microfluidic Device Polyvinyl Chloride Tubing Glass Capillary Needle Co-flow Microfluidic Generator Droplet Generation Ultraviolet Glue Syringe
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