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JoVE Journal Bioengineering
Cellulær affinitet av partikkelstabilisert emulsjon for å øke antigen internalisering
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Cellulær affinitet av partikkelstabilisert emulsjon for å øke antigen internalisering

Article DOI: 10.3791/64406-v • 10:06 min • September 2nd, 2022
September 2nd, 2022 •
*1,2,3, *3,4, 3,4, 3, 1,2
1Graduate School of Bio-Applications and Systems Engineering, Tokyo University of Agriculture and Technology, 2Institute of Global Innovation Research, Tokyo University of Agriculture and Technology, 3State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, 4University of Chinese Academy of Sciences
* These authors contributed equally

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For å rasjonelt designe effektive adjuvanser utviklet vi poly-melkesyre-koglykolsyre nanopartikkelstabilisert Pickering-emulsjon (PNPE). PNPE hadde unik mykhet og et hydrofobt grensesnitt for potent cellulær kontakt og tilbød antigenbelastning med høyt innhold, forbedret leveringssystemets cellulære affinitet til antigenpresenterende celler og induserte effektiv internalisering av antigener.

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Bioteknologi utgave 187
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