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Establishing a Mouse Contusion Spinal Cord Injury Model Based on a Minimally Invasive Technique
JoVE Journal
Neuroscience
This content is Free Access.
JoVE Journal Neuroscience
Establishing a Mouse Contusion Spinal Cord Injury Model Based on a Minimally Invasive Technique
DOI:

07:17 min

September 07, 2022

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Chapters

  • 00:05Introduction
  • 01:06Mechanism of the Spinal Cord Injury Coaxial Platform and Mechanical Tests
  • 02:02Locating and Laminectomy of the 9th Thoracic Vertebra (T9)
  • 04:11T9 Contusion Injury
  • 05:23Results: Sagittal Sections on the 1st and 56th Days After Injury to the Spinal Cord of Mice
  • 06:38Conclusion

Summary

Automatic Translation

Minimally invasive techniques and a simple laboratory device improve the reproducibility of the spinal cord injury model by reducing operative damage to the experimental animals and allowing anatomical morphology maintenance. The method is worthwhile because the reliable results and reproducible procedure facilitate investigations of the mechanisms of disease reparation.

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