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Testing Cancer Immunotherapeutics in a Humanized Mouse Model Bearing Human Tumors
JoVE Journal
Cancer Research
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JoVE Journal Cancer Research
Testing Cancer Immunotherapeutics in a Humanized Mouse Model Bearing Human Tumors

Testing Cancer Immunotherapeutics in a Humanized Mouse Model Bearing Human Tumors

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15:24 min

December 16, 2022

DOI:

15:24 min
December 16, 2022

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Summary

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This protocol outlines the generation of human immune system (HIS) mice for immuno-oncology studies. Instructions and considerations in the use of this model for testing human immunotherapeutics on human tumors implanted in this model are presented with an emphasis on characterizing the response of the human immune system to the tumor.

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