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A Rabbit Aortic Valve Stenosis Model Induced by Direct Balloon Injury
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A Rabbit Aortic Valve Stenosis Model Induced by Direct Balloon Injury

Article DOI: 10.3791/65078-v • 07:10 min • March 31st, 2023
March 31st, 2023 •
*1, *1, 1, 1, 1, 1, 1,2, 3, 1,4
1Cardiovascular Research Institute for Intractable Disease, College of Medicine, The Catholic University of Korea, 2Division of Cardiology, Incheon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, 3College of Pharmacy and Natural Medicine Research Institute, Mokpo National University, 4Division of Cardiology, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea
* These authors contributed equally

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Summary
Automatic Translation

An appropriate animal model is needed to understand the pathologic mechanisms underlying aortic valve stenosis (AVS) and to evaluate the efficacy of therapeutic interventions. The present protocol describes a new procedure for developing the AVS rabbit model via a direct balloon injury in vivo.

Tags

Rabbit Aortic Valve Stenosis Model Direct Balloon Injury Animal Models Pathologic Mechanisms AVS Rabbit Models Large Animal Studies Dietary Supplementation Genetic Manipulation Experimental Studies Protocol New Zealand White Rabbits Surgical Procedure Post-operative Care Initiation And Progression Of AVS Pathological Mechanisms
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