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Journal / Bioengineering / Terapia sonodinamica per il trattamento del…
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Bioengineering

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JoVE Journal Bioengineering
Terapia sonodinamica per il trattamento del glioblastoma multiforme in un modello murino utilizzando un sistema portatile ad ultrasuoni focalizzato da banco
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Terapia sonodinamica per il trattamento del glioblastoma multiforme in un modello murino utilizzando un sistema portatile ad ultrasuoni focalizzato da banco

Article DOI: 10.3791/65114-v • 09:07 min • February 10th, 2023
February 10th, 2023 •
1,2, 1,2, 3, 1,2, 4, 1, 1, 5, 1, 1,2,4,6,7
1Department of Neurosurgery, Johns Hopkins University School of Medicine, 2Department of Biomedical Engineering, Johns Hopkins University, 3Krieger School of Arts and Sciences, Johns Hopkins University, 4Department of Electrical Engineering and Computer Science, Johns Hopkins University, 5Department of Radiology, Cancer Imaging Division, Johns Hopkins University School of Medicine, 6Department of Mechanical Engineering, Johns Hopkins University, 7Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine

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Qui, descriviamo un protocollo che descrive in dettaglio come eseguire la terapia sonodinamica in un modello di glioblastoma murino in vivo utilizzando ultrasuoni focalizzati guidati dalla risonanza magnetica.

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Terapia sonodinamica Glioblastoma multiforme Modello murino Sistema a ultrasuoni focalizzati Agente sonosensibilizzante Aumento della sensibilità Trattamenti clinici Tassi di sopravvivenza a lungo termine Trattamento non invasivo Trattamento specifico del tumore Sonosensibilizzatori Specie ossidative reattive Apoptosi Parametri standardizzati Studi preclinici Ottimizzazione della strategia terapeutica Modello preclinico di roditore GBM FUS guidato dalla risonanza magnetica (MRgFUS) Targeting specifico Tumore cerebrale Dispositivo da banco
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