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Using Nicotine in a Silica-Exposed Mouse Model to Promote Lung Epithelial-Mesenchymal Transition

Article DOI: 10.3791/65127-v • 06:12 min • March 3rd, 2023
March 3rd, 2023 •
*1,2,3,4, *1,2,3,4, 1,2,3,4, 1,2,3,4, 1,2,3,4, 1,2,3,4, 1,2,3,4, 1,2,3,4
1Key Laboratory of Industrial Dust Control and Occupational Health of the Ministry of Education, Anhui University of Science and Technology, 2Key Laboratory of Industrial Dust Deep Reduction and Occupational Health and Safety of Anhui Higher Education Institutes, Anhui University of Science and Technology, 3Anhui Province Engineering Laboratory of Occupational Health and Safety, 4School of Medicine, Department of Medical Frontier Experimental Center, Anhui University of Science and Technology
* These authors contributed equally

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Summary
Automatic Translation

This study describes a mouse model to study the synergistic effect of nicotine on the progression of pulmonary fibrosis in experimental silicosis mice. The dual-exposure mouse model simulates the pathological progression in the lung after simultaneous exposure to nicotine and silica. The methods described are simple and highly reproducible.

Tags

Nicotine Silica Lung Epithelial-mesenchymal Transition Silicosis Mouse Model Chronic Nicotine Ingestion Repeated Exposure To Silica Lung Fibrosis Cigarette Smoke Subcutaneous Injection Crystalline Silica Powder Inhalation Exposure Double-exposed Mouse Model
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