Deep brain stimulation triggered by a patient-specific neural biomarker of a high-symptom state may better control symptoms of major depressive disorder compared to continuous, open-loop stimulation. This protocol provides a workflow for identifying a patient-specific neural biomarker and controlling the delivery of therapeutic stimulation based on the identified biomarker.
Sellers, K. K., Khambhati, A. N., Stapper, N., Fan, J. M., Rao, V. R., Scangos, K. W., Chang, E. F., Krystal, A. D. Closed-Loop Neurostimulation for Biomarker-Driven, Personalized Treatment of Major Depressive Disorder. J. Vis. Exp. (197), e65177, doi:10.3791/65177 (2023).