Genetic Profiling and Genome-Scale Dropout Screening to Identify Therapeutic Targets in Mouse Models of Malignant Peripheral Nerve Sheath Tumor

Brittany Turner-Ivey; Jody Fromm Longo; Dorea P. Jenkins; Stephen T. Guest; Steven L. Carroll

doi:10.3791/65430

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Genetic Profiling and Genome-Scale Dropout Screening to Identify Therapeutic Targets in Mouse Models of Malignant Peripheral Nerve Sheath Tumor

JoVE Journal
Cancer Research

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JoVE Journal Cancer Research

Genetic Profiling and Genome-Scale Dropout Screening to Identify Therapeutic Targets in Mouse Models of Malignant Peripheral Nerve Sheath Tumor

1,097 Views

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09:33 min

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August 25, 2023

DOI:

10.3791/65430-v

DOI:

10.3791/65430-v

•

09:33 min

August 25, 2023

•

1080 Views

Brittany Turner-Ivey¹, Jody Fromm Longo², Dorea P. Jenkins², Stephen T. Guest³, Steven L. Carroll^1,2

¹Hollings Cancer Center,Medical University of South Carolina ²Department of Pathology and Laboratory Medicine,Medical University of South Carolina ³Department of Computational Medicine and Bioinformatics,University of Michigan, Ann Arbor

Summary

We have developed a cross-species comparative oncogenomics approach utilizing genomic analyses and functional genomic screens to identify and compare therapeutic targets in tumors arising in genetically engineered mouse models and the corresponding human tumor type.