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JoVE Journal
Medicine
Exploring the Pharmacological Action and Molecular Mechanism of Salidroside in Inhibiting MCF-7 C...
Exploring the Pharmacological Action and Molecular Mechanism of Salidroside in Inhibiting MCF-7 C...
JoVE Journal
Medicine
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JoVE Journal Medicine
Exploring the Pharmacological Action and Molecular Mechanism of Salidroside in Inhibiting MCF-7 Cell Proliferation and Migration

Exploring the Pharmacological Action and Molecular Mechanism of Salidroside in Inhibiting MCF-7 Cell Proliferation and Migration

Full Text
2,406 Views
11:13 min
June 9, 2023

DOI: 10.3791/65634-v

Lijuan Cui1, Chuan Ye1, Ting Luo1, Hongyan Jiang1, Boan Lai1, Haojun Wang1, Zhongyi Chen1, Yi Li2

1Pathology Department,Suining Central Hospital, 2General Surgery Day Ward, Department of General Surgery,the Third People's Hospital of Chengdu & the Affiliated Hospital of Southwest Jiaotong University

The present protocol describesa comprehensive strategy for evaluating the pharmacological action and mechanism of salidroside in inhibiting MCF-7 cell proliferation and migration.

We focus on exploring active compounds derived from natural products and their potential in treating breast cancer. So specifically, we aim to alluded the pharmacological effects of cellular side and its molecular mechanisms in combating breast cancer. Currently, reliable experimental techniques are lacking to validate the salidroside molecular targets in treating breast cancer.

One significant finding in the field is a potential proliferation and migration of MCF-7 cells through the regulation of PI3K-AKT-HIF-1a-FoxO1 segmenting. The laboratory's future research directly is to explore the pathologic mechanisms underlying breast cancer onset, development, prognosis, and outcome. Additionally, we screen for actual small natural drugs derived from nature sources that may add in breast cancer prevention and treatment.

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