Name: Laparoscopic Non-Mesh Cerclage Pectopexy with Uterine Preservation for Pelvic Organ Prolapse (Video) | JoVE Journal
Uploaded: 2024-10-25T14:20:00.000+00:00
Duration: 3 min 30 s
Description: Learn laparoscopic non-mesh cerclage pectopexy for treating pelvic organ prolapse while preserving the uterus. This technique uses permanent sutures to suspend the uterus, eliminating mesh-related complications and reducing healthcare costs.

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We thank each participant and staff for their assistance in this study. Special thanks to Hong L for her assistance in figure editing.

The Institutional Review Board of the hospital approved the protocol (IRB Approval Number 2021-040). Informed consent for publication was obtained from each participant. Inclusion criteria encompassed women diagnosed with uterine prolapse at Pelvic Organ Prolapse Quantification (POP-Q) stage 2 or higher with related symptoms who were eligible for surgical treatments and were able to read Chinese. Assessment for eligibility was performed by a gynecologist at the hospital. All patients had a standardized preoperative POP assessment using the POP-Q system in the lithotomy position as well as via ultrasonography. Patients with co-existing anterior/posterior defects or concomitant incontinence surgery were also included. Women with contraindications for laparoscopic surgery, established genital malignancy, previous surgical treatment of vault prolapse, language issues and those not available for follow-up were excluded. Patients agreed to return the questionnaires and visit the follow-up appointments. See Table of Materials for details about equipment and other materials used in this protocol.
1. Planning for prolapse surgery
<ol>
	<li>Inform the patients about the risks and potential complications, including the possibility of switching to open laparotomy, excessive bleeding, wound infection, and postoperative recurrence.</li>
	<li>After obtaining informed consent, administer enoxaparin sodium injection (100 AXaIU/kg) for perioperative thrombosis prophylaxis.</li>
	<li>Have an anesthesiologist administer endotracheal general anesthesia and monitor vital signs. Administer perioperative prophylactic antibiotics intravenously 30 min before surgery; use cefuroxime (1.5 g) unless there is an allergic history.</li>
	<li>Following field skin disinfection, establish pneumoperitoneum using the Veress needle technique for insufflation via the umbilicus9.
	<ol>
		<li>Place a 10 mm trocar via the umbilicus for an optical device, and introduce three 5 mm trocars (see Table of Materials) under direct visualization in the lower abdomen.</li>
		<li>Maintain gas intake flow at 20 L/min, and intraperitoneal pressure at 12 mmHg.</li>
	</ol>
	</li>
</ol>
2. Laparoscopic Non-Mesh Cerclage Pectopexy with Uterine Preservation (LNMCPUP) approach
<ol>
	<li>Perform laparoscopic bilateral salpingo-oophorectomy in postmenopausal patients. Electrocoagulate and sever the round ligament (Figure 1), attaching it to the cervical isthmus.</li>
	<li>Open the vesico-uterine recursion peritoneum to expose the uterine artery.</li>
	<li>Expose&#160;the iliopectineal ligament near the landmarks-the round ligament and the obliterated umbilical artery-make an incision in the peritoneum and detach the surrounding soft tissue between the lateral umbilical ligament and round ligament, below which the iliopectineal ligament is located. Avoid contact with the external iliac vessel and obturator nerve in the target surgical region.</li>
	<li>To perform cervico-isthmic cerclage, start at 4 o&#39;clock on the right side and go counterclockwise (Figure 2A), use a permanent suture (size 2, see Table of Materials) in the uterine isthmus to suture, ligate, and attach a round ligament to the cervical isthmus. Complete one round until the starting point is reached, performing peripheral movements with the needle around the cervix (Figure 2B). Tighten and secure the stitch after completing the cervical cerclage (Figure 2C).</li>
	<li>Embed the permanent suture into the round ligament, ending at the iliopectineal ligament (Figure 3A,B).</li>
	<li>Insert the stitch through the iliopectineal ligament (Figure 4A,B), and ensure suspension without tension (Figure 5).</li>
	<li>Repeat steps 2.1-2.6 on the other side of the pelvis.</li>
	<li>Perform peritoneal closure with an absorbable synthetic polyglactin braided suture (size 2-0, see Table of Materials).</li>
	<li>Perform anterior and/or posterior colporrhaphy if patients suffering from symptomatic POP &#8805; stage 2 including anterior and/or posterior vaginal wall defect. Separate the vaginal wall from cervix and pouch sutured for 1 to 2 rounds in the outer bladder/rectal fascia to repair the cystocele/rectocele.Suture arcus tendinous fascia pelvis/arcus tendinous musculi levator ani in a U-shape and closed anterior and/or posterior vagina wall.</li>
	<li>Perform anti-incontinence surgery inside-out tension-free vaginal tape-obturator (TVT-O) before LNMCPUP if patients are diagnosed with serious Stress Urinary Incontinence (SUI) based on preoperative urodynamic examination. If patients were diagnosed with middle SUI, counsel them about the risk of postoperative SUI condition aggravation, and perform TVT-O at the patients&#39; discretion. 
	NOTE: The LNMCPUP technique is shown in a schematic diagram (Figure 6).</li>
</ol>
3. Management after LNMCPUP surgery
<ol>
	<li>Record necessary data, including the operation time of LNMCPUP, total blood loss, and associated complications.</li>
	<li>Advise all postmenopausal patients to use low-dose transvaginal estrogen for 6 weeks after surgery.</li>
	<li>Advise all patients to engage in pelvic floor exercises starting 8 weeks after surgery.</li>
	<li>Perform follow-up of patients 6 weeks, 6 months, and 1 year after surgery.
	<ol>
		<li>Conduct a gynecological examination using POP-Q system for assessing prolapse, an important reference point is the hymen.Grade genital prolapse stages 1-4 according to achieved optimal POP-Q scores.</li>
		<li>Ask patients to complete Patient Global Impression of Improvement (PGI) questionnaire to evaluate the postoperative condition relative to the condition before the surgical intervention. Use a single question to rate the condition; the answer will be on a scale from &#34;1. Very much better&#34; to &#34;7. Very much worse&#34;10.</li>
		<li>Ask the patients to complete the Prolapse Quality of Life (P-QOL) questionnaire and the Pelvic Organ Prolapse Urinary Incontinence Sexual Questionnaire (PISQ-12). 
		NOTE: The PISQ-12 is a self-administered questionnaire that evaluates the sexual function of women with pelvic organ prolapse or urinary incontinence11.</li>
	</ol>
	</li>
	<li>Calculate the subjective and objective success rates. Define objective success as the absence of prolapse of the vault beyond the hymen, with optimal POP-Q stage &#8804;1. Define subjective success as the absence of bothersome bulge symptoms (vaginal bulging and protrusion according to the validated questionnaire), without repeat surgery or pessary use for recurrent vault prolapse12. 
	NOTE: We considered an objective success rate of our medical care if POP-Q measurements Ba, Bp, and C &#8804; 0 (optimal POP-Q stage &#8804; 1) and a subjective success rate of our medical care if the PGI was&#8804; 2. Systematic assessment was done for complications such as de novo SUI, reoperation for SUI or recurrent POP, and de novo dyspareunia.</li>
</ol>

Uterine-Preserving Laparoscopic Cerclage Pectopexy 

<ol><li>Subak, L. L., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Cost+of+pelvic+organ+prolapse+surgery+in+the+United+States%5BTitle%5D)+AND+%22Obstet+Gynecol%22%5BJournal%5D)">Cost of pelvic organ prolapse surgery in the United States.</a> Obstet Gynecol. 98 (4), 646-651 (2001).</li>
<li>Seisen, T., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Results+obtained+after+robotic-assisted+laparoscopic+sacral+colpopexy+for+the+management+of+urogenital+prolapse%3A+a+review%5BTitle%5D)+AND+%22Prog+Urol%22%5BJournal%5D)">Results obtained after robotic-assisted laparoscopic sacral colpopexy for the management of urogenital prolapse: a review.</a> Prog Urol. 22 (3), 146-153 (2012).</li>
<li>Maher, C., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Surgery+for+women+with+apical+vaginal+prolapse%5BTitle%5D)+AND+%22Cochrane+Database+Syst+Rev%22%5BJournal%5D)">Surgery for women with apical vaginal prolapse.</a> Cochrane Database Syst Rev. 10 (10), CD012376(2016).</li>
<li>Noé, K. G., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Laparoscopic+pectopexy%3A+a+prospective%2C+randomized%2C+comparative+clinical+trial+of+standard+laparoscopic+sacral+colpocervicopexy+with+the+new+laparoscopic+pectopexy-postoperative+results+and+intermediate-term+follow-up+in+a+pilot+study%5BTitle%5D)+AND+%22J+Endourol%22%5BJournal%5D)">Laparoscopic pectopexy: a prospective, randomized, comparative clinical trial of standard laparoscopic sacral colpocervicopexy with the new laparoscopic pectopexy-postoperative results and intermediate-term follow-up in a pilot study.</a> J Endourol. 29 (2), 210-215 (2015).</li>
<li>Maher, C., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Surgery+for+women+with+apical+vaginal+prolapse%5BTitle%5D)+AND+%22Cochrane+Database+Syst.+Rev%22%5BJournal%5D)">Surgery for women with apical vaginal prolapse.</a> Cochrane Database Syst. Rev. 7 (7), CD012376(2023).</li>
<li>Zhang, W., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Laparoscopic+non-mesh+cerclage+pectopexy+for+pelvic+organ+prolapse%5BTitle%5D)+AND+%22J+Vis+Exp%22%5BJournal%5D)">Laparoscopic non-mesh cerclage pectopexy for pelvic organ prolapse.</a> J Vis Exp. (187), e64388(2022).</li>
<li>Korbly, N. B., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Patient+preferences+for+uterine+preservation+and+hysterectomy+in+women+with+pelvic+organ+prolapse%5BTitle%5D)+AND+%22Am+J+Obstet+Gynecol%22%5BJournal%5D)">Patient preferences for uterine preservation and hysterectomy in women with pelvic organ prolapse.</a> Am J Obstet Gynecol. 209 (5), 470.e1-470.e6 (2013).</li>
<li>Meriwether, K. V., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Uterine+preservation+vs+hysterectomy+in+pelvic+organ+prolapse+surgery%3A+a+systematic+review+with+meta-analysis+and+clinical+practice+guidelines%5BTitle%5D)+AND+%22Am+J+Obstet+Gynecol%22%5BJournal%5D)">Uterine preservation vs hysterectomy in pelvic organ prolapse surgery: a systematic review with meta-analysis and clinical practice guidelines.</a> Am J Obstet Gynecol. 219 (2), 129-146.e2 (2018).</li>
<li>Zeng, L., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Introduction+of+intracapsular+rotary-cut+procedures+%28IRCP%29%3A+A+modified+hysteromyomectomy+procedures+facilitating+fertility+preservation%5BTitle%5D)+AND+%22J+Vis+Exp%22%5BJournal%5D)">Introduction of intracapsular rotary-cut procedures (IRCP): A modified hysteromyomectomy procedures facilitating fertility preservation.</a> J Vis Exp. (143), e58410(2019).</li>
<li>Srikrishna, S., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Validation+of+the+Patient+Global+Impression+of+Improvement+%28PGI-I%29+for+urogenital+prolapse%5BTitle%5D)+AND+%22Int+Urogynecol+J%22%5BJournal%5D)">Validation of the Patient Global Impression of Improvement (PGI-I) for urogenital prolapse.</a> Int Urogynecol J. 21 (5), 523-528 (2010).</li>
<li>Occhino, J. A., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Validation+of+a+visual+analog+scale+form+of+the+pelvic+organ+prolapse%2Furinary+incontinence+sexual+function+questionnaire%5BTitle%5D)+AND+%22Female+Pelvic+Med+ReconstrSurg%22%5BJournal%5D)">Validation of a visual analog scale form of the pelvic organ prolapse/urinary incontinence sexual function questionnaire.</a> Female Pelvic Med ReconstrSurg. 17 (5), 246-248 (2011).</li>
<li>Barber, M. D., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Pelvic+floor+disorders+network.+Defining+success+after+surgery+for+pelvic+organ+prolapse%5BTitle%5D)+AND+%22Obstet+Gynecol%22%5BJournal%5D)">Pelvic floor disorders network. Defining success after surgery for pelvic organ prolapse.</a> Obstet Gynecol. 114 (3), 600-609 (2010).</li>
<li>Smith, F. J., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Lifetime+risk+of+undergoing+surgery+for+pelvic+organ+prolapse%5BTitle%5D)+AND+%22Obstet+Gynecol%22%5BJournal%5D)">Lifetime risk of undergoing surgery for pelvic organ prolapse.</a> Obstet Gynecol. 116 (5), 1096-1100 (2010).</li>
<li>Sarlos, D., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Laparoscopic+sacrocolpopexy+for+uterine+and+post-hysterectomy+prolapse%3A+anatomical+results%2C+quality+of+life+and+perioperative+outcome-a+prospective+study+with+101+cases%5BTitle%5D)+AND+%22Int+Urogynecol+J+Pelvic+Floor+Dysfunct%22%5BJournal%5D)">Laparoscopic sacrocolpopexy for uterine and post-hysterectomy prolapse: anatomical results, quality of life and perioperative outcome-a prospective study with 101 cases.</a> Int Urogynecol J Pelvic Floor Dysfunct. 19 (10), 1415-1422 (2008).</li>
<li>Banerjee, C., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((a+new+technique+of+prolapse+surgery+for+obese+patients%5BTitle%5D)+AND+%22Arch+Gynecol+Obstet%22%5BJournal%5D)">a new technique of prolapse surgery for obese patients.</a> Arch Gynecol Obstet. 284 (3), 631-635 (2011).</li>
<li>Szymczak, P., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Comparison+of+laparoscopic+techniques+for+apical+organ+prolapse+repair+-+a+systematic+review+of+the+literature%5BTitle%5D)+AND+%22Neurourol+Urodyn%22%5BJournal%5D)">Comparison of laparoscopic techniques for apical organ prolapse repair - a systematic review of the literature.</a> Neurourol Urodyn. 38 (8), 2031-2050 (2019).</li>
<li>Obut, M., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Comparison+of+the+quality+of+life+and+female+sexual+function+following+laparoscopic+pectopexy+and+laparoscopic+sacrohysteropexy+in+apical+prolapse+patients%5BTitle%5D)+AND+%22Gynecol+Minim+Invasive+Ther%22%5BJournal%5D)">Comparison of the quality of life and female sexual function following laparoscopic pectopexy and laparoscopic sacrohysteropexy in apical prolapse patients.</a> Gynecol Minim Invasive Ther. 10 (2), 96-103 (2021).</li>
<li>Chan, C. Y. W., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((A+systematic+review+of+the+surgical+management+of+apical+pelvic+organ+prolapse%5BTitle%5D)+AND+%22Int+Urogynecol+J%22%5BJournal%5D)">A systematic review of the surgical management of apical pelvic organ prolapse.</a> Int Urogynecol J. 34 (4), 825-841 (2023).</li>
<li>Anglim, B., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((How+do+patients+and+surgeons+decide+on+uterine+preservation+or+hysterectomy+in+apical+prolapse%5BTitle%5D)+AND+%22Int+Urogynecol+J%22%5BJournal%5D)">How do patients and surgeons decide on uterine preservation or hysterectomy in apical prolapse.</a> Int Urogynecol J. 29 (8), 1075-1079 (2018).</li>
<li>Kostov, S., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/pubmed?term=((Corona+mortis%2C+aberrant+obturator+vessels%2C+accessory+obturator+vessels%3A+clinical+applications+in+gynecology%5BTitle%5D)+AND+%22Folia+Morphol+%28Warsz%29%22%5BJournal%5D)">Corona mortis, aberrant obturator vessels, accessory obturator vessels: clinical applications in gynecology.</a> Folia Morphol (Warsz). 80 (4), 776-785 (2021).</li>
</ol>

No conflicts of interest were declared by the authors.

A significant number of elderly women worldwide experience Pelvic Organ Prolapse (POP), which involves the descent of at least one pelvic organ. As society ages, the demand for POP surgery is expected to rise dramatically13. Laparoscopic Sacrocolpopexy (LS) is the primary surgical technique for addressing apical prolapse. However, the high incidence of postoperative defecation problems associated with LS cannot be overlooked14. Laparoscopic Pectopexy (LP)&#160; an alternati...

Pelvic organ prolapse (POP) significantly impacts the well-being of a substantial portion of parous women over 50 years old1. With an increasing average lifespan, a higher number of women will require POP surgery. The gold standard for treating uterine prolapse is laparoscopic sacrocolpopexy (LS), in which the vaginal apex is attached to the sacrum over the third and fourth sacral vertebrae using mesh, boasting a success rate exceeding 95% and long-term durability2. However, LS is a challenging procedure commonly associated with postoperative defecation problems3. Additionally, LS may not be suitable for obese patients. Laparoscopic pectopexy (LP), in which the iliopectineal ligaments are used for a bilateral mesh fixation of vaginal vault or cervical stump, has emerged as a viable alternative to LS for addressing apical prolapse, due to comparable clinical efficacy and a lower incidence of defecation disorders4.
However, the usage of synthetic mesh for apical support in LS and LP causes mesh-related complications, increasing patient suffering and medical expenses5. Our team has published a new procedure called laparoscopic non-mesh cerclage pectopexy (LNMCP), embedding permanent cervical cerclage sutures in the round ligament until the iliopectineal ligament. This was successfully performed with high objective and subjective success rates6. Recent evidence suggests that many women with prolapse issues desire to preserve their uterus, which is paramount for maintaining self-confidence, self-esteem, and a sense of femininity7.
The current research reports the development of a novel approach known as laparoscopic non-mesh cerclage pectopexy with uterine preservation for POP (LNMCPUP) for addressing apical prolapse. This novel technique involves embedding cervical cerclage sutures in the round ligament until the iliopectineal ligament, resulting in a firm uterine suspension. In addition, without using synthetic mesh, this procedure obviates mesh erosion while reducing medical costs. Moreover, this procedure ensures that the uterus is preserved, thereby minimizing perioperative risks associated with hysterectomy and eliminating significant alterations in POP surgery outcomes8.

<table><tbody><tr><td>5 mm trocars</td><td>KARL STORZ, Germany</td><td>30160X</td><td>Endoscopic equipment</td></tr><tr><td>10 mm trocars&amp;nbsp;</td><td>KARL STORZ, Germany</td><td>30160 H2</td><td>Endoscopic equipment</td></tr><tr><td>Cefuroxime sodium for injection&amp;nbsp;</td><td>YOUCARE , China</td><td>H20063758</td><td>Prophylactic antibiotics</td></tr><tr><td>Enoxaparin sodium for injection&amp;nbsp;</td><td>TECHDOW , China</td><td>H20056847</td><td>Perioperative thrombosis prophylaxis</td></tr><tr><td>Ethibond size 2</td><td>ETHICON, USA</td><td>X519H&amp;nbsp;</td><td>Nonabsorbable braided polyester</td></tr><tr><td>VICRYL 2-0</td><td>ETHICON, USA</td><td>VCP317H</td><td>Absorbable braided suture</td></tr></tbody></table>

laparoscopic non-mesh cerclage pectopexy with uterine preservation for pelvic organ prolapse

Laparoscopic Non-Mesh Cerclage Pectopexy with Uterine Preservation for Pelvic Organ Prolapse

Pelvic organ prolapse (POP) affects millions of women globally and carries a significant socioeconomic burden. Adequate apical support is essential for treating POP. Recent research has increasingly validated the efficacy and safety of laparoscopic pectopexy (LP) for addressing apical POP. However, the cost of synthetic mesh and associated complications restrict the widespread use of this technique. Our team previously published a study describing a novel, non-mesh procedure called laparoscopic non-mesh cerclage pectopexy (LNMCP), demonstrating successful outcomes with satisfactory objective and subjective success rates. Many patients express a preference for retaining their uterus during prolapse surgery due to considerations related to sexuality, partnership, and body image. 
The present research introduces a novel approach known as laparoscopic non-mesh cerclage pectopexy with uterine preservation (LNMCPUP) for POP, wherein the uterus is suspended to the iliopectineal ligament through the round ligament using permanent cerclage sutures. We successfully performed this procedure in 14 cases at our hospital, six of whom still had menstruation, and the remaining eight were postmenopausal, with a mean operation time of 54.43 min (&plusmn; 10.18 min) and an average bleeding volume of 53.57 mL (&plusmn; 48.77 mL). The mean follow-up duration was 19.71 &plusmn; 15.87 months. The objective success rate of LNMCPUP was 100%, with a subjective success rate of 92.86%. No significant complications were observed during or after surgery. LNMCPUP integrates cervical cerclage and shortening of the round ligament, as well as LP without using mesh, thereby eliminating the risk of mesh erosion and lowering healthcare costs. Moreover, this novel technique is relatively easy to master, making it accessible even in rural and underdeveloped areas where synthetic mesh is unavailable. Therefore, it is worthwhile to adopt LNMCPUP in POP patients who desire the preservation of their uterus.

We successfully performed Laparoscopic Non-Mesh Cerclage Pectopexy with Uterine Preservation (LNMCPUP) in 14 patients over the past 2 years, six of whom were premenopausal, and the remaining eight were postmenopausal. Their average ± Standard deviation (SD) age was 52.93 ± 9.94 years, with a mean ± SD Body mass index (BMI) of 23.46 ± 1.95. The average ± SD bleeding volume during surgery was 53.57 ± 48.77 mL, and the mean ± SD operation time was 54.43 ± 10.18 min. The mean ± SD follow-up duration was 19.7...

Here we introduce a novel approach known as laparoscopic non-mesh cerclage pectopexy with uterine preservation for pelvic organ prolapse (LNMCPUP) for patients who wish to preserve their uterus. Permanent cerclage sutures are used to suspend the uterus to the iliopectineal ligament through the round ligament.

Pelvic organ prolapse (POP) affects millions of women globally and carries a significant socioeconomic burden. Adequate apical support is essential for ...

laparoscopic-non-mesh-cerclage-pectopexy-with-uterine-preservation

Research

JoVE Journal

Medicine

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Learn laparoscopic non-mesh cerclage pectopexy for treating pelvic organ prolapse while preserving the uterus. This technique uses permanent sutures to suspend the uterus, eliminating mesh-related complications and reducing healthcare costs.

Laparoscopic Non-Mesh Cerclage Pectopexy with Uterine Preservation for Pelvic Organ Prolapse

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