Multiscale Investigations of Cortical Processing by Integrating Laminar Polytrodes and Optogenetics with Micro Electrocorticography in Rodents

Pierre-Marie Garderes; Nicholas Chin; Daniel E. Feldman; Kristofer E. Bouchard

doi:10.3791/67983

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Multiscale Investigations of Cortical Processing by Integrating Laminar Polytrodes and Optogenetics with Micro Electrocorticography in Rodents

JoVE Journal
Neuroscience

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JoVE Journal Neuroscience

Multiscale Investigations of Cortical Processing by Integrating Laminar Polytrodes and Optogenetics with Micro Electrocorticography in Rodents

246 Views

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07:52 min

•

May 23, 2025

DOI:

10.3791/67983-v

DOI:

10.3791/67983-v

•

07:52 min

May 23, 2025

•

246 Views

¹Department of Neuroscience,UC Berkeley ²Biological Systems and Engineering Division,Lawrence Berkeley National Lab ³Helen Wills Neuroscience Institute,UC Berkeley ⁴Redwood Center for Theoretical Neuroscience,UC Berkeley ⁵Scientific Data Division,Lawrence Berkeley National Lab

Summary

Here, we present two protocols for high-density micro-electrocorticography (µEcoG) recording in rats and mice, including surgical, implantation, and recording methods. µECoG recordings are performed in combination with either laminar polytrode recording in the rat auditory cortex or with optogenetic manipulation of neural activity in the mouse somatosensory cortex.