This study investigated the clinical effects of early intensive motor intervention combined with conventional rehabilitation training on gross motor development and ADL ability in infants and children with developmental delay through a randomized controlled trial. The results of the study showed that the treatment group significantly outperformed the control group in terms of improvement in AIMS score (from 36.80 ± 11.38 to 53.12 ± 7.48), PDMS-GM standardized total score (from 18.65 ± 2.33 to 28.03 ± 2.51), and ADL score (from 32.89 ± 7.02 to 58.92 ± 6.34) ( P<0.05). To enhance replicability, we standardized the suspension protocol: wobble 10-15/min without midline loss; progress only after >30s stable midline in two trials. Sessions began with 5-8 min of core stabilization and goal-directed cues. When sway occurred, we reduced tension or amplitude and shortened trials. These procedures align with guidance and likely support gains.
Theoretical basis and empirical validation of early motor interventions
A systematic review by Dumuids-Vernet et al.11 indicated that effective early motor interventions require three key features: a clear definition of infant dysfunction, a standardized and easily replicable intervention program, and a requirement for infants to engage in active movement. The mesh-intensive suspension training designed in this study fully met these characteristics: replicability of the protocol was ensured through standardized suspension device settings (e.g., height and tension adjustments); and infants were asked to make active postural and movement pattern adjustments through, among other things, core muscle group training and balance coordination training. The effectiveness of reticular intensive suspension training was directly verified in a study by Yi-Wen Zhang et al.13, whose results showed that the improvement in PDMS-GM scores of the treatment group was significantly better than that of the control group after 3 months of intervention (P<0.05). By extending the intervention cycle to 12 months, this study not only confirmed the short-term effect of this training method, but also proved its long-term sustained benefits, providing a strong evidence-based basis for the clinical application of early exercise intervention.
Comprehensive benefits of multidimensional interventions
The study by Gündoğmuş et al.14 emphasized that early intervention should go beyond single motor training and incorporate multidimensional components such as sensory and cognitive. The innovative integration of sensory integration training (e.g., tactile brushing, dally ball) into the intervention program in the present study may be an important reason for the significant improvement in ADL scores (79.2% improvement)15. This multidimensional intervention idea is highly compatible with the GAME intervention concept proposed by Gündoğmuş. A meta-analysis by Baker et al.7 found that task-specific training was effective in improving motor function in children with cerebral palsy (effect size d = 0.42). The motor control training in this study (e.g., seated balance training on a wobbly suspension net) can be considered as advanced task-specific training, which simulates the challenges of daily living by progressively increasing environmental instability (wobbling frequency of 10-15 times/min). This may be a key mechanism for the 50.3% improvement in the PDMS-GM "postural" area score in the treatment group, and provides a new paradigm for practicing Baker's principle of "task specificity"7.
Innovations in family involvement and intervention models
The multicenter study by Dong et al.5 demonstrated that parent-implemented early intervention (PIEIP) significantly improves multidomain competence in children with global developmental delays (15%-22% increase in motor, social, and language developmental quotients). Although the parent-implemented model was not directly used in this study, the introduction of common household items (e.g., fabrics of different textures, household balls) into the sensory integration training set the stage for home continuation of the training. Future studies may draw on Dong's protocol to develop a home version of the intervention manual based on suspension training, which may further enhance the effectiveness of the intervention. In contrast, the institutional intervention in the present study, although more intensive (5 times per week), may not be as cost-effective as the home model.
Intervention suitability for special populations
Lestari et al.4 demonstrated that infant massage promotes weight gain in low birth weight infants (mean weight gain in the intervention group was 18% higher than in the control group). Although nutritional interventions were not included in this study, exercises such as prone elbow support in suspension training may indirectly promote growth and development by enhancing digestive system function. The synergistic effect of suspension training and nutritional interventions could be explored in the future, especially for children with combined growth retardation. Smythe et al.16called for focusing on early intervention implementation in low-income areas. The suspension device in this study has the characteristics of cost-controllability and easy operation, which meet the needs of application in resource-limited areas. However, it should be noted that the subjects of this study were infants aged 6-36 months, while Smythe emphasized that early intervention should start from the neonatal period, which suggests that suspension training programs suitable for different developmental stages need to be developed in the future.
Mechanisms and theoretical innovations
From the perspective of neurodevelopmental theory, the significant effect of the present study may be attributed to multiple mechanisms: (1) the dynamic plane of instability provided by suspension training can enhance the vestibular sensory inputs and promote sensory integration16; (2) the playful design (e.g., the ball pushing game) in the training stimulates the active participation of the infants, which validates the "task-oriented" theory proposed by Baker et al.7. According to the "task-oriented theory" proposed, we can boldly hypothesize that suspension training, while enhancing trunk stability, also makes the feeding passage more unobstructed, thereby optimizing swallowing function. This provides new evidence for a generalization effect of early intervention.
Research limitations and future directions
This study had the following limitations: (1) small sample size (n = 56), which met the statistical requirements but the subgroup analysis was not sufficiently valid; (2) the impact of the intervention on cognitive and language development was not assessed, which limits a comprehensive understanding of the intervention's broader effects on non-motor domains of development; and (3) there was a lack of long term follow up data to assess the sustainability of the intervention effect.
Based on the insights from the literature, future studies should (1) expand the sample and conduct stratified analyses (e.g., by etiology or severity); (2) develop a joint home-institutional intervention model that combines parent implementation strategies with the professional training strengths of this study and nutritional support3; (3) explore low-cost adaptive equipment to enhance feasibility in resource-limited areas; and (4) increase the number of objective metrics such as functional brain imaging17, to further elucidate neural mechanisms.
This study confirmed the significant improvement effect of early intensive motor intervention combined with conventional rehabilitation training on gross motor development and ADL in infants and toddlers with developmental delay. Combined with literature analysis, active movement, multisensory stimulation, and family involvement are the key elements of early intervention. Early intensive motor training is worth promoting in clinical rehabilitation as an effective intervention. Future studies should further explore the long-term effects of intervention, family participation patterns, and the synergistic effects of multimodal intervention, incorporating robust methods like blinded video analysis to optimize rehabilitation strategies for children with developmental delay.