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Biology

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Optimization of the Ugi Reaction Using Parallel Synthesis and Automated Liquid Handling
 

Optimization of the Ugi Reaction Using Parallel Synthesis and Automated Liquid Handling

Article doi: 10.3791/942
November 11th, 2008

Summary November 11th, 2008

The Ugi reaction has proved to be a convenient way to quickly create diverse libraries of compounds. It involves the reaction of an amine, an aldehyde, a carboxylic acid and an isonitrile typically in methanol at room temperature. In this video, we utilize a 48-slot Mettler-Toledo MiniBlock equipped with filtration tubes and a Mettler-Toledo MiniMapper automated liquid handler was used to deliver the reagents and solvent. The parameters of interest were the concentration, the solvent composition and the excess of some of the reagents.

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