Waiting
Login processing...

Trial ends in Request Full Access Tell Your Colleague About Jove
Journal / Neuroscience / Delivery of Antibodies into the Murine Brain via…
JoVE Journal
Neuroscience

A subscription to JoVE is required to view this content.

JoVE Journal Neuroscience
Delivery of Antibodies into the Murine Brain via Convection-enhanced Delivery
Establishing Primary In Vitro Culture of Leptomeningeal Lymphatic Endothelial Cells (LLECs) (Video) | JoVE
Journal (Neuroscience)
Establishing Primary In Vitro Culture of Leptomeningeal Lymphatic Endothelial Cells (LLECs) (Video) | JoVE
TACI: An ImageJ Plugin for 3D Calcium Imaging Analysis
Journal (Neuroscience)
TACI: An ImageJ Plugin for 3D Calcium Imaging Analysis
 

Delivery of Antibodies into the Murine Brain via Convection-enhanced Delivery

Article DOI: 10.3791/59675-v • 08:22 min • July 18th, 2019
July 18th, 2019 •
1, 1, 1, 1
1Institute of Laboratory Animal Science, University of Zurich

Chapters

Summary
Automatic Translation

Convection-enhanced delivery (CED) is a method enabling effective delivery of therapeutics into the brain by direct perfusion of large tissue volumes. The procedure requires the use of catheters and an optimized injection procedure. This protocol describes a methodology for CED of an antibody into a mouse brain.

Tags

Convection-enhanced Delivery Antibodies Murine Brain Step Catheter System Uniform Perfusion Blood-brain Barrier Neurological Conditions Fused Silica Capillary Tubing Microforge 27-gauge Needle Syringe Stereotactic Robot Cyanoacrylate Adhesive
Read Article

Get cutting-edge science videos from JoVE sent straight to your inbox every month.

Waiting X
Simple Hit Counter