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JoVE Journal Neuroscience
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A Benchtop Approach to the Location Specific Blood Brain Barrier Opening using Focused Ultrasound in a Rat Model

Article DOI: 10.3791/61113-v • 09:17 min • June 13th, 2020
June 13th, 2020 •
1, 1, 2, 1
1Department of Radiology, University of Alabama at Birmingham, 2Department of Neurobiology, University of Alabama at Birmingham

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Summary
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Focused ultrasound with microbubble agents can open the blood brain barrier focally and transiently. This technique has been used to deliver a wide range of agents across the blood brain barrier. This article provides a detailed protocol for the localized delivery to the rodent brain with or without MRI guidance.

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Benchtop Blood-brain Barrier Focused Ultrasound Rat Model Micro-bubbles Non-invasive Delivery Catheter Plug Saline Tail Vein Catheter Evans Blue Dye Gadobutrol MRI Contrast Experimental Agent Sheath Lab Tape Anesthesia Line Stereotactic Frame MRI Bed T2 Weighted Images
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