Darrell N. Kotton Center for Regenerative Medicine Boston University and Boston Medical Center Biography Publications Institution JoVE Articles Darrell N. Kotton has not added a biography. If you are Darrell N. Kotton and would like to personalize this page please email our Author Liaison for assistance. Publications Human Distal Airways Contain a Multipotent Secretory Cell That Can Regenerate Alveoli Nature. Apr, 2022 | Pubmed ID: 35355013 Editorial: Progenitors and Stem Cells in Thyroid Development, Disease, and Regeneration Frontiers in Endocrinology. 2022 | Pubmed ID: 35211095 Patient-specific IPSCs Carrying an SFTPC Mutation Reveal the Intrinsic Alveolar Epithelial Dysfunction at the Inception of Interstitial Lung Disease Cell Reports. Aug, 2021 | Pubmed ID: 34469722 Morphological Cell Profiling of SARS-CoV-2 Infection Identifies Drug Repurposing Candidates for COVID-19 Proceedings of the National Academy of Sciences of the United States of America. 09, 2021 | Pubmed ID: 34413211 Differentiation of Human Pluripotent Stem Cells into Functional Airway Basal Stem Cells STAR Protocols. 09, 2021 | Pubmed ID: 34355203 Derivation of Thyroid Follicular Cells From Pluripotent Stem Cells: Insights From Development and Implications for Regenerative Medicine Frontiers in Endocrinology. 2021 | Pubmed ID: 33959101 Derivation of Airway Basal Stem Cells from Human Pluripotent Stem Cells Cell Stem Cell. 01, 2021 | Pubmed ID: 33098807 Epithelial Stem and Progenitor Cells in Lung Repair and Regeneration Annual Review of Physiology. 02, 2021 | Pubmed ID: 33074772 Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2 Molecular Cell. 12, 2020 | Pubmed ID: 33259812 SARS-CoV-2 Infection of Pluripotent Stem Cell-Derived Human Lung Alveolar Type 2 Cells Elicits a Rapid Epithelial-Intrinsic Inflammatory Response Cell Stem Cell. 12, 2020 | Pubmed ID: 32979316 Organoids Model Transcriptional Hallmarks of Oncogenic KRAS Activation in Lung Epithelial Progenitor Cells Cell Stem Cell. 10, 2020 | Pubmed ID: 32891189 The in Vivo Genetic Program of Murine Primordial Lung Epithelial Progenitors Nature Communications. 01, 2020 | Pubmed ID: 32005814 Reconstructed Single-Cell Fate Trajectories Define Lineage Plasticity Windows During Differentiation of Human PSC-Derived Distal Lung Progenitors Cell Stem Cell. 04, 2020 | Pubmed ID: 32004478 Derivation of Self-renewing Lung Alveolar Epithelial Type II Cells from Human Pluripotent Stem Cells Nature Protocols. 12, 2019 | Pubmed ID: 31732721 Generation of a Purified IPSC-Derived Smooth Muscle-like Population For Cell Sheet Engineering Stem Cell Reports. 09, 2019 | Pubmed ID: 31422908 Circulating Truncated Alpha-1 Antitrypsin Glycoprotein in Patient Plasma Retains Anti-Inflammatory Capacity Journal of Immunology (Baltimore, Md. : 1950). 04, 2019 | Pubmed ID: 30796179 Single-Cell Transcriptomic Profiling of Pluripotent Stem Cell-Derived SCGB3A2+ Airway Epithelium Stem Cell Reports. 05, 2018 | Pubmed ID: 29657097 Claudin-18: Unexpected Regulator of Lung Alveolar Epithelial Cell Proliferation The Journal of Clinical Investigation. 03, 2018 | Pubmed ID: 29400691 Differentiation of Human Pluripotent Stem Cells into Functional Lung Alveolar Epithelial Cells Cell Stem Cell. 10, 2017 | Pubmed ID: 28965766 Pluripotent Stem Cell Differentiation Reveals Distinct Developmental Pathways Regulating Lung- Versus Thyroid-lineage Specification Development (Cambridge, England). 11, 2017 | Pubmed ID: 28947536 Vascular Smooth Muscle Cells Derived from Inbred Swine Induced Pluripotent Stem Cells for Vascular Tissue Engineering Biomaterials. Dec, 2017 | Pubmed ID: 28942128 Prospective Isolation of NKX2-1-expressing Human Lung Progenitors Derived from Pluripotent Stem Cells The Journal of Clinical Investigation. Jun, 2017 | Pubmed ID: 28463226 Efficient Derivation of Functional Human Airway Epithelium from Pluripotent Stem Cells Via Temporal Regulation of Wnt Signaling Cell Stem Cell. 06, 2017 | Pubmed ID: 28366587 Regenerative Therapy for Hypothyroidism: Mechanisms and Possibilities Molecular and Cellular Endocrinology. 04, 2017 | Pubmed ID: 27876515 Regeneration of Thyroid Function by Transplantation of Differentiated Pluripotent Stem Cells Cell Stem Cell. Nov, 2015 | Pubmed ID: 26593959 Emergence of a Stage-dependent Human Liver Disease Signature with Directed Differentiation of Alpha-1 Antitrypsin-deficient IPS Cells Stem Cell Reports. May, 2015 | Pubmed ID: 25843048 Embryonic and Induced Pluripotent Stem Cells for Lung Regeneration Annals of the American Thoracic Society. Mar, 2015 | Pubmed ID: 25830836 Targeted Correction and Restored Function of the CFTR Gene in Cystic Fibrosis Induced Pluripotent Stem Cells Stem Cell Reports. Apr, 2015 | Pubmed ID: 25772471 Derivation of Endodermal Progenitors From Pluripotent Stem Cells Journal of Cellular Physiology. Feb, 2015 | Pubmed ID: 25160562 Lung Regeneration: Mechanisms, Applications and Emerging Stem Cell Populations Nature Medicine. Aug, 2014 | Pubmed ID: 25100528 KDR Identifies a Conserved Human and Murine Hepatic Progenitor and Instructs Early Liver Development Cell Stem Cell. Jun, 2013 | Pubmed ID: 23746980 The Aryl Hydrocarbon Receptor Directs Hematopoietic Progenitor Cell Expansion and Differentiation Blood. Jul, 2013 | Pubmed ID: 23723449 Lentiviral Delivery of RNAi for in Vivo Lineage-specific Modulation of Gene Expression in Mouse Lung Macrophages Molecular Therapy : the Journal of the American Society of Gene Therapy. Apr, 2013 | Pubmed ID: 23403494 Induced Pluripotent Stem Cells Utilizzato Per Rivelare Le Azioni Di Droga in Una Famiglia Di Sindrome QT Lunga Con Genetica Complessa The Journal of General Physiology. Jan, 2013 | Pubmed ID: 23277474 Mouse ESC Differentiation to Nkx2.1+ Lung and Thyroid Progenitors Bio-protocol. Nov, 2012 | Pubmed ID: 27453901 The 2012 Nobel Prize in Physiology or Medicine: Democratizing Pluripotency for Lung Researchers American Journal of Respiratory and Critical Care Medicine. Dec, 2012 | Pubmed ID: 23204376 I Fattori Di Trascrizione Come Grainyhead 2 E NK2-Homeobox 1 Formano Un Loop Normativo Che Le Coordinate Delle Cellule Epiteliali Del Polmone Morfogenesi E Differenziamento The Journal of Biological Chemistry. Oct, 2012 | Pubmed ID: 22955271 Sindrome Di Stenosi Aortica Sopravalvolare Modellazione Con Cellule Staminali Umane Pluripotenti Indotte Circulation. Oct, 2012 | Pubmed ID: 22914687 Rigenerazione Di Nuova Generazione: La Speranza E La Campagna Pubblicitaria Della Ricerca Sulle Cellule Staminali Del Polmone American Journal of Respiratory and Critical Care Medicine. Jun, 2012 | Pubmed ID: 22517787 Derivazione Efficiente Del Polmone Purificato E Progenitori Della Tiroide Da Cellule Staminali Embrionali Cell Stem Cell. Apr, 2012 | Pubmed ID: 22482505 Linee Progenitrici Endodermico Autorinnovabile Generate Da Cellule Staminali Pluripotenti Umane Cell Stem Cell. Apr, 2012 | Pubmed ID: 22482503 Manutenzione E Riparazione Dell'endotelio Polmonare Non Prevede Contributi Da Cellule Precursori Endoteliali Derivate Dal Midollo Osseo American Journal of Respiratory Cell and Molecular Biology. Jul, 2012 | Pubmed ID: 22323363 Caso Record Del Massachusetts General Hospital. Caso 2-2012. Una Donna Di 63 Anni Con Dispnea E Rapidamente Progressiva Insufficienza Respiratoria The New England Journal of Medicine. Jan, 2012 | Pubmed ID: 22256809 Sono Staminali Embrionali E Indotta Da Cellule Staminali Pluripotenti Lo Stesse O Diverse? Implicazioni Per Il Loro Potenziale Uso Terapeutico Cell Cycle (Georgetown, Tex.). Jan, 2012 | Pubmed ID: 22186787 Ruolo Di Nanog Nel Mantenimento Delle Cellule Staminali Stromali Di Midollo Osseo Durante La Rigenerazione Ossea Natal Post Biochemical and Biophysical Research Communications. Jan, 2012 | Pubmed ID: 22142851 Proprietà Biofisiche Dei Canali Potassio Lento in Human Embryonic Stem Cell Derivato Cardiomyocytes Coinvolgono Stechiometria Subunità The Journal of Physiology. Dec, 2011 | Pubmed ID: 22025662 Cambiamento a Livello Di Codice: Ricerca Delle Malattie Del Polmone Nell'era Della Pluripotenza Indotta American Journal of Physiology. Lung Cellular and Molecular Physiology. Dec, 2011 | Pubmed ID: 21984571 Il Passaggio Da Colture Cellulari Di Creature: in Vivo Imaging Di Piccoli Animali in Medicina Rigenerativa Sperimentale Molecular Therapy : the Journal of the American Society of Gene Therapy. Nov, 2011 | Pubmed ID: 21952170 Cella Plasticità Nella Riparazione E Danno Polmonare: Rapporto Da Un'officina NHLBI, 19-20 Aprile 2010 Proceedings of the American Thoracic Society. Jun, 2011 | Pubmed ID: 21653526 Mouse ES E Le Cellule IPS Possono Formare Simile Endoderma Definitivo Nonostante Le Differenze Nei Geni Imprinted The Journal of Clinical Investigation. Jun, 2011 | Pubmed ID: 21537085 FOXO1 Modula La Differenziazione Degli Osteoblasti Bone. May, 2011 | Pubmed ID: 21281751 Generazione Del Polmone Privo Di Transgene Specifici Per La Malattia Umana Indotta Staminali Pluripotenti Usando Una Cassetta Singola Ad Accisa Lentivirali Stem Cell Stem Cells (Dayton, Ohio). Oct, 2010 | Pubmed ID: 20715179 Il Ruolo Delle Cellule Dendritiche Derivate Da Pelle Di Adescamento Delle Cellule CD8 + T Dopo Immunizzazione Con Lentivectors Journal of Immunology (Baltimore, Md. : 1950). May, 2010 | Pubmed ID: 20357252 Miglioramento Di Enfisema Nei Topi Attraverso La Trasduzione Lentivirale Di Macrofagi Alveolari Polmonari Longevi The Journal of Clinical Investigation. Jan, 2010 | Pubmed ID: 20038801 L'escissione Della Riprogrammazione Transgeni Migliora Il Potenziale Di Differenziazione Delle Cellule IPS Generato Con Un Singolo Vettore Soggetti Ad Accisa Stem Cells (Dayton, Ohio). Jan, 2010 | Pubmed ID: 19904830 Proteinosi Alveolare Polmonare: Una Storia Di Panchina Al Capezzale Della Disfunzione Di Fattore Del Granulocyte Colony-stimulating Chest. Aug, 2009 | Pubmed ID: 19666756 Analisi Trascrizionale Di Guarigione Della Frattura E L'induzione Di Geni Correlati a Cellule Staminali Embrionali PloS One. 2009 | Pubmed ID: 19415118 Generazione Di Cellule Staminali Pluripotenti Indotte Utilizzando Una Cassetta Singola Cellula Formativa Lentivirali Stem Cells (Dayton, Ohio). Mar, 2009 | Pubmed ID: 19096035 Espressione Sostenuta Di Alpha1-antitripsina Dopo Il Trapianto Di Cellule Staminali Ematopoietiche Manipolati American Journal of Respiratory Cell and Molecular Biology. Aug, 2008 | Pubmed ID: 18323534 Un'altra Tacca Nella Biologia Delle Cellule Staminali: Cellule Staminali Intestinali Della Drosofila E La Specifica Dei Destini Delle Cellule BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology. Feb, 2008 | Pubmed ID: 18200564 La Durata Prolungata Dei Macrofagi Alveolari American Journal of Respiratory Cell and Molecular Biology. Apr, 2008 | Pubmed ID: 18192503 Sistema Lentivirale Dual-promotore Permette L'espressione Inducibile Delle Proteine Nocive Nei Macrofagi Journal of Immunological Methods. Jan, 2008 | Pubmed ID: 17967462 Cellule Staminali Del Polmone Cell and Tissue Research. Jan, 2008 | Pubmed ID: 17805578 Esogeno Controllo Dell'espressione Genica Dei Mammiferi Tramite Modulazione Di Terminazione Traslazionale Nature Medicine. Sep, 2006 | Pubmed ID: 16892063 Insufficienza Del Midollo Osseo Per Ricostituire L'epitelio Polmonare American Journal of Respiratory Cell and Molecular Biology. Oct, 2005 | Pubmed ID: 15961722 L'efficienza Di Trasduzione Di Staminali Ematopoietiche Murine Altamente Purificato Le Cellule Da Lentivirali E Oncoretroviral Vettori in Condizioni Di Minima Manipolazione in Vitro Molecular Therapy : the Journal of the American Society of Gene Therapy. Jun, 2005 | Pubmed ID: 15922964 Una Popolazione Di Cellule Staminali Romanzo Nel Fegato Adulto Con Potente Attività Ricostituzione Ematopoietica Blood. Sep, 2005 | Pubmed ID: 15870171 Polmone Embrionale Lato Popolazione Cellule Sono Precursori Ematopoietici E Vascolari American Journal of Respiratory Cell and Molecular Biology. Jul, 2005 | Pubmed ID: 15802552 Le Cellule Staminali Del Polmone: Nuovi Paradigmi Experimental Hematology. Apr, 2004 | Pubmed ID: 15050743 Translational Physiology: Origin and Phenotype of Lung Side Population Cells American Journal of Physiology. Lung Cellular and Molecular Physiology. Sep, 2004 | Pubmed ID: 15047566 Lato Popolazione Cellule E Bcrp1 Espressione Nel Polmone American Journal of Physiology. Lung Cellular and Molecular Physiology. Jul, 2003 | Pubmed ID: 12626330 Cellule Staminali Antigene-1 Espressione Nell'endotelio Vascolare Polmonare American Journal of Physiology. Lung Cellular and Molecular Physiology. Jun, 2003 | Pubmed ID: 12611818 Generazione di sfere 3D e colture di interfaccia aria-liquido 2D di cellule epiteliali alveolari di tipo 2 derivate da cellule staminali pluripotenti indotte dall'uomo Rhiannon B. Werder*1,2,3, Jessie Huang*1,2, Kristine M. Abo1,2, Olivia T. Hix1,2, Kasey Minakin1,2, Konstantinos-Dionysios Alysandratos1,2, Carly Merritt1,2, Kayleigh Berthiaume1,2, Andrea B. Alber1,2, Claire L. Burgess1,2, Darrell N. Kotton*1,2, Andrew A. Wilson*1,2 1Center for Regenerative Medicine, Boston University and Boston Medical Center, 2The Pulmonary Center and Department of Medicine, Boston University School of Medicine, 3QIMR Berghofer Medical Research Institute JoVE 63875 Developmental Biology Generazione di cellule pluripotenti indotte umane staminali da sangue periferico mediante il STEMCCA lentivirale Vector Andreia Gianotti Sommer1, Sarah S. Rozelle1, Spencer Sullivan2, Jason A. Mills3, Seon-Mi Park1, Brenden W. Smith1, Amulya M. Iyer1, Deborah L. French3, Darrell N. Kotton1, Paul Gadue3, George J. Murphy1, Gustavo Mostoslavsky1 1Center for Regenerative Medicine (CReM), Boston University School of Medicine, 2Department of Hematology, Children's Hospital of Philadelphia, 3Center for Cellular and Molecular Therapeutics, Children's Hospital of Philadelphia JoVE 4327 Biology
Generazione di sfere 3D e colture di interfaccia aria-liquido 2D di cellule epiteliali alveolari di tipo 2 derivate da cellule staminali pluripotenti indotte dall'uomo Rhiannon B. Werder*1,2,3, Jessie Huang*1,2, Kristine M. Abo1,2, Olivia T. Hix1,2, Kasey Minakin1,2, Konstantinos-Dionysios Alysandratos1,2, Carly Merritt1,2, Kayleigh Berthiaume1,2, Andrea B. Alber1,2, Claire L. Burgess1,2, Darrell N. Kotton*1,2, Andrew A. Wilson*1,2 1Center for Regenerative Medicine, Boston University and Boston Medical Center, 2The Pulmonary Center and Department of Medicine, Boston University School of Medicine, 3QIMR Berghofer Medical Research Institute JoVE 63875 Developmental Biology
Generazione di cellule pluripotenti indotte umane staminali da sangue periferico mediante il STEMCCA lentivirale Vector Andreia Gianotti Sommer1, Sarah S. Rozelle1, Spencer Sullivan2, Jason A. Mills3, Seon-Mi Park1, Brenden W. Smith1, Amulya M. Iyer1, Deborah L. French3, Darrell N. Kotton1, Paul Gadue3, George J. Murphy1, Gustavo Mostoslavsky1 1Center for Regenerative Medicine (CReM), Boston University School of Medicine, 2Department of Hematology, Children's Hospital of Philadelphia, 3Center for Cellular and Molecular Therapeutics, Children's Hospital of Philadelphia JoVE 4327 Biology
