David Kleinfeld Department of Physics University of California, San Diego Biography Publications Institution JoVE Articles David Kleinfeld has not added a biography. If you are David Kleinfeld and would like to personalize this page please email our Author Liaison for assistance. Publications The Brainstem Oscillator for Whisking and the Case for Breathing As the Master Clock for Orofacial Motor Actions Cold Spring Harbor Symposia on Quantitative Biology. Apr, 2015 | Pubmed ID: 25876629 Deflection of a Vibrissa Leads to a Gradient of Strain Across Mechanoreceptors in a Mystacial Follicle Journal of Neurophysiology. Apr, 2015 | Pubmed ID: 25855692 Fluorescently Labeled Peptide Increases Identification of Degenerated Facial Nerve Branches During Surgery and Improves Functional Outcome PloS One. 2015 | Pubmed ID: 25751149 Robust and Fragile Aspects of Cortical Blood Flow in Relation to the Underlying Angioarchitecture Microcirculation (New York, N.Y. : 1994). Apr, 2015 | Pubmed ID: 25705966 Feedback in the Brainstem: an Excitatory Disynaptic Pathway for Control of Whisking The Journal of Comparative Neurology. Apr, 2015 | Pubmed ID: 25503925 Muscles Involved in Naris Dilation and Nose Motion in Rat Anatomical Record (Hoboken, N.J. : 2007). Mar, 2015 | Pubmed ID: 25257748 The Musculature That Drives Active Touch by Vibrissae and Nose in Mice Anatomical Record (Hoboken, N.J. : 2007). Nov, 2014 | Pubmed ID: 25408106 Cell-based Reporters Reveal in Vivo Dynamics of Dopamine and Norepinephrine Release in Murine Cortex Nature Methods. Dec, 2014 | Pubmed ID: 25344639 Activation and Measurement of Free Whisking in the Lightly Anesthetized Rodent Nature Protocols. Aug, 2014 | Pubmed ID: 24992095 How the Brainstem Controls Orofacial Behaviors Comprised of Rhythmic Actions Trends in Neurosciences. Jul, 2014 | Pubmed ID: 24890196 More Than a Rhythm of Life: Breathing As a Binder of Orofacial Sensation Nature Neuroscience. May, 2014 | Pubmed ID: 24762718 Spectral Methods for Functional Brain Imaging Cold Spring Harbor Protocols. Mar, 2014 | Pubmed ID: 24591695 Optically Induced Occlusion of Single Blood Vessels in Rodent Neocortex Cold Spring Harbor Protocols. Dec, 2013 | Pubmed ID: 24298038 Mediation of Muscular Control of Rhinarial Motility in Rats by the Nasal Cartilaginous Skeleton Anatomical Record (Hoboken, N.J. : 2007). Dec, 2013 | Pubmed ID: 24249396 The Challenge of Connecting the Dots in the B.R.a.I.N Neuron. Oct, 2013 | Pubmed ID: 24139032 All-optical Osteotomy to Create Windows for Transcranial Imaging in Mice Optics Express. Oct, 2013 | Pubmed ID: 24104230 ReaChR: a Red-shifted Variant of Channelrhodopsin Enables Deep Transcranial Optogenetic Excitation Nature Neuroscience. Oct, 2013 | Pubmed ID: 23995068 Two-photon Imaging of Blood Flow in the Rat Cortex Cold Spring Harbor Protocols. Aug, 2013 | Pubmed ID: 23906919 The Cortical Angiome: an Interconnected Vascular Network with Noncolumnar Patterns of Blood Flow Nature Neuroscience. Jul, 2013 | Pubmed ID: 23749145 Hierarchy of Orofacial Rhythms Revealed Through Whisking and Breathing Nature. May, 2013 | Pubmed ID: 23624373 All-optical in Situ Histology of Brain Tissue with Femtosecond Laser Pulses Cold Spring Harbor Protocols. Apr, 2013 | Pubmed ID: 23547156 The Smallest Stroke: Occlusion of One Penetrating Vessel Leads to Infarction and a Cognitive Deficit Nature Neuroscience. Jan, 2013 | Pubmed ID: 23242312 Vectorization of Optically Sectioned Brain Microvasculature: Learning Aids Completion of Vascular Graphs by Connecting Gaps and Deleting Open-ended Segments Medical Image Analysis. Aug, 2012 | Pubmed ID: 22854035 Dorsorostral Snout Muscles in the Rat Subserve Coordinated Movement for Whisking and Sniffing Anatomical Record (Hoboken, N.J. : 2007). Jul, 2012 | Pubmed ID: 22641389 Interferometric Detection of Action Potentials Cold Spring Harbor Protocols. 2012 | Pubmed ID: 22383643 Two-photon Microscopy As a Tool to Study Blood Flow and Neurovascular Coupling in the Rodent Brain Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. Feb, 2012 | Pubmed ID: 22293983 Prospect for Feedback Guided Surgery with Ultra-short Pulsed Laser Light Current Opinion in Neurobiology. Feb, 2012 | Pubmed ID: 22088392 Sniffing and Whisking in Rodents Current Opinion in Neurobiology. Dec, 2011 | Pubmed ID: 22177596 Neuronal Basis for Object Location in the Vibrissa Scanning Sensorimotor System Neuron. Nov, 2011 | Pubmed ID: 22078505 Large-scale Automated Histology in the Pursuit of Connectomes The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Nov, 2011 | Pubmed ID: 22072665 Primary Motor Cortex Reports Efferent Control of Vibrissa Motion on Multiple Timescales Neuron. Oct, 2011 | Pubmed ID: 22017992 Quality Metrics to Accompany Spike Sorting of Extracellular Signals The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jun, 2011 | Pubmed ID: 21677152 A Guide to Delineate the Logic of Neurovascular Signaling in the Brain Frontiers in Neuroenergetics. 2011 | Pubmed ID: 21559095 Fluctuating and Sensory-induced Vasodynamics in Rodent Cortex Extend Arteriole Capacity Proceedings of the National Academy of Sciences of the United States of America. May, 2011 | Pubmed ID: 21536897 Photon Counting, Censor Corrections, and Lifetime Imaging for Improved Detection in Two-photon Microscopy Journal of Neurophysiology. Jun, 2011 | Pubmed ID: 21471395 Characterizing Ligand-gated Ion Channel Receptors with Genetically Encoded Ca2++ Sensors PloS One. 2011 | Pubmed ID: 21305050 Spatio-temporally Focused Femtosecond Laser Pulses for Nonreciprocal Writing in Optically Transparent Materials Optics Express. Nov, 2010 | Pubmed ID: 21164813 Chronic Optical Access Through a Polished and Reinforced Thinned Skull Nature Methods. Dec, 2010 | Pubmed ID: 20966916 Temporally Focused Femtosecond Laser Pulses for Low Numerical Aperture Micromachining Through Optically Transparent Materials Optics Express. Aug, 2010 | Pubmed ID: 20721196 Topological Basis for the Robust Distribution of Blood to Rodent Neocortex Proceedings of the National Academy of Sciences of the United States of America. Jul, 2010 | Pubmed ID: 20616030 Automatic Identification of Fluorescently Labeled Brain Cells for Rapid Functional Imaging Journal of Neurophysiology. Sep, 2010 | Pubmed ID: 20610792 Optimizing the Fluorescent Yield in Two-photon Laser Scanning Microscopy with Dispersion Compensation Optics Express. Jun, 2010 | Pubmed ID: 20588500 An in Vivo Biosensor for Neurotransmitter Release and in Situ Receptor Activity Nature Neuroscience. Jan, 2010 | Pubmed ID: 20010818 Rapid Determination of Particle Velocity from Space-time Images Using the Radon Transform Journal of Computational Neuroscience. Aug, 2010 | Pubmed ID: 19459038 Correlations of Neuronal and Microvascular Densities in Murine Cortex Revealed by Direct Counting and Colocalization of Nuclei and Vessels The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Nov, 2009 | Pubmed ID: 19923289 Enter the Ratrix Proceedings of the National Academy of Sciences of the United States of America. Nov, 2009 | Pubmed ID: 19906991 Severe Blood-brain Barrier Disruption and Surrounding Tissue Injury Stroke; a Journal of Cerebral Circulation. Dec, 2009 | Pubmed ID: 19893002 The Glial Cell Response is an Essential Component of Hypoxia-induced Erythropoiesis in Mice The Journal of Clinical Investigation. Nov, 2009 | Pubmed ID: 19809162 Acute Vascular Disruption and Aquaporin 4 Loss After Stroke Stroke; a Journal of Cerebral Circulation. Jun, 2009 | Pubmed ID: 19372455 A Proposal for a Coordinated Effort for the Determination of Brainwide Neuroanatomical Connectivity in Model Organisms at a Mesoscopic Scale PLoS Computational Biology. Mar, 2009 | Pubmed ID: 19325892 Phase-to-rate Transformations Encode Touch in Cortical Neurons of a Scanning Sensorimotor System Nature Neuroscience. Apr, 2009 | Pubmed ID: 19270688 Plasma-mediated Ablation: an Optical Tool for Submicrometer Surgery on Neuronal and Vascular Systems Current Opinion in Biotechnology. Feb, 2009 | Pubmed ID: 19269159 Active Dilation of Penetrating Arterioles Restores Red Blood Cell Flux to Penumbral Neocortex After Focal Stroke Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. Apr, 2009 | Pubmed ID: 19174826 Stimulus-induced Changes in Blood Flow and 2-deoxyglucose Uptake Dissociate in Ipsilateral Somatosensory Cortex The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Dec, 2008 | Pubmed ID: 19118167 Chapter 10. In Vivo Measurements of Blood Flow and Glial Cell Function with Two-photon Laser-scanning Microscopy Methods in Enzymology. 2008 | Pubmed ID: 19007667 Advancing Multifocal Nonlinear Microscopy: Development and Application of a Novel Multibeam Yb:KGd(WO4)2 Oscillator Optics Express. Oct, 2008 | Pubmed ID: 18958037 Texture Coding in the Rat Whisker System: Slip-stick Versus Differential Resonance PLoS Biology. Aug, 2008 | Pubmed ID: 18752354 Finding Coherence in Spontaneous Oscillations Nature Neuroscience. Sep, 2008 | Pubmed ID: 18725901 'Where' and 'what' in the Whisker Sensorimotor System Nature Reviews. Neuroscience. Aug, 2008 | Pubmed ID: 18641667 Biomechanics of the Vibrissa Motor Plant in Rat: Rhythmic Whisking Consists of Triphasic Neuromuscular Activity The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Mar, 2008 | Pubmed ID: 18367610 Wilder Penfield in the Age of YouTube: Visualizing the Sequential Activation of Sensorimotor Areas Across Neocortex Neuron. Dec, 2007 | Pubmed ID: 18054853 Suppressed Neuronal Activity and Concurrent Arteriolar Vasoconstriction May Explain Negative Blood Oxygenation Level-dependent Signal The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Apr, 2007 | Pubmed ID: 17442830 Large Two-photon Absorptivity of Hemoglobin in the Infrared Range of 780-880 Nm The Journal of Chemical Physics. Jan, 2007 | Pubmed ID: 17228976 Active Spatial Perception in the Vibrissa Scanning Sensorimotor System PLoS Biology. Feb, 2007 | Pubmed ID: 17227143 Is There a Common Origin to Surround-inhibition As Seen Through Electrical Activity Versus Hemodynamic Changes? Focus on "Duration-dependent Response in SI to Vibrotactile Stimulation in Squirrel Monkey" Journal of Neurophysiology. Mar, 2007 | Pubmed ID: 17215499 Penetrating Arterioles Are a Bottleneck in the Perfusion of Neocortex Proceedings of the National Academy of Sciences of the United States of America. Jan, 2007 | Pubmed ID: 17190804 Active Sensation: Insights from the Rodent Vibrissa Sensorimotor System Current Opinion in Neurobiology. Aug, 2006 | Pubmed ID: 16837190 Exploratory Whisking by Rat is Not Phase Locked to the Hippocampal Theta Rhythm The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jun, 2006 | Pubmed ID: 16775139 Seeing What the Mouse Sees with Its Vibrissae: a Matter of Behavioral State Neuron. May, 2006 | Pubmed ID: 16701202 MPScope: a Versatile Software Suite for Multiphoton Microscopy Journal of Neuroscience Methods. Sep, 2006 | Pubmed ID: 16621010 Targeted Insult to Subsurface Cortical Blood Vessels Using Ultrashort Laser Pulses: Three Models of Stroke Nature Methods. Feb, 2006 | Pubmed ID: 16432519 Science is an Adventure, Not a Battle Nature. Jan, 2006 | Pubmed ID: 16397477 Two-photon Imaging of Cortical Surface Microvessels Reveals a Robust Redistribution in Blood Flow After Vascular Occlusion PLoS Biology. Feb, 2006 | Pubmed ID: 16379497 Coding of Stimulus Frequency by Latency in Thalamic Networks Through the Interplay of GABAB-mediated Feedback and Stimulus Shape Journal of Neurophysiology. Mar, 2006 | Pubmed ID: 16267113 From Art to Engineering? The Rise of in Vivo Mammalian Electrophysiology Via Genetically Targeted Labeling and Nonlinear Imaging PLoS Biology. Oct, 2005 | Pubmed ID: 16207078 Activation of Nucleus Basalis Facilitates Cortical Control of a Brain Stem Motor Program Journal of Neurophysiology. Jul, 2005 | Pubmed ID: 15728764 Positive Feedback in a Brainstem Tactile Sensorimotor Loop Neuron. Feb, 2005 | Pubmed ID: 15694330 Current Flow in Vibrissa Motor Cortex Can Phase-lock with Exploratory Rhythmic Whisking in Rat Journal of Neurophysiology. Sep, 2004 | Pubmed ID: 15331651 Goal-directed Whisking Increases Phase-locking Between Vibrissa Movement and Electrical Activity in Primary Sensory Cortex in Rat Proceedings of the National Academy of Sciences of the United States of America. Aug, 2004 | Pubmed ID: 15297618 Developmental Regulation of Active and Passive Membrane Properties in Rat Vibrissa Motoneurones The Journal of Physiology. Apr, 2004 | Pubmed ID: 14766934 Frisking the Whiskers: Patterned Sensory Input in the Rat Vibrissa System Neuron. Jan, 2004 | Pubmed ID: 14741099 Imaging Reveals Synaptic Targets of a Swim-terminating Neuron in the Leech CNS The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Dec, 2003 | Pubmed ID: 14673004 Reversing Cerebellar Long-term Depression Proceedings of the National Academy of Sciences of the United States of America. Dec, 2003 | Pubmed ID: 14671315 Vibrissa Movement Elicited by Rhythmic Electrical Microstimulation to Motor Cortex in the Aroused Rat Mimics Exploratory Whisking Journal of Neurophysiology. Nov, 2003 | Pubmed ID: 12904336 Unilateral Vibrissa Contact: Changes in Amplitude but Not Timing of Rhythmic Whisking Somatosensory & Motor Research. 2003 | Pubmed ID: 12850826 All-optical Histology Using Ultrashort Laser Pulses Neuron. Jul, 2003 | Pubmed ID: 12848930 Rhythmic Whisking by Rat: Retraction As Well As Protraction of the Vibrissae is Under Active Muscular Control Journal of Neurophysiology. Jan, 2003 | Pubmed ID: 12522163 Closed-loop Neuronal Computations: Focus on Vibrissa Somatosensation in Rat Cerebral Cortex (New York, N.Y. : 1991). Jan, 2003 | Pubmed ID: 12466215 Spectral Mixing of Rhythmic Neuronal Signals in Sensory Cortex Proceedings of the National Academy of Sciences of the United States of America. Nov, 2002 | Pubmed ID: 12403828 Adaptive Filtering of Vibrissa Input in Motor Cortex of Rat Neuron. Jun, 2002 | Pubmed ID: 12086648 Coherent Electrical Activity Between Vibrissa Sensory Areas of Cerebellum and Neocortex is Enhanced During Free Whisking Journal of Neurophysiology. Apr, 2002 | Pubmed ID: 11929931 Cortical Imaging Through the Intact Mouse Skull Using Two-photon Excitation Laser Scanning Microscopy Microscopy Research and Technique. Feb, 2002 | Pubmed ID: 11877806 का निर्माण सेल आधारित न्यूरोट्रांसमीटर के ऑप्टिकल पता लगाने के लिए स्नायुसंचारी फ्लोरोसेंट इंजीनियर रिपोर्टर (CNiFERs) Emre Lacin1, Arnaud Muller2, Marian Fernando1, David Kleinfeld2,3, Paul A. Slesinger1 1Department of Neuroscience, Icahn School of Medicine at Mount Sinai, 2Department of Physics, University of California, San Diego, 3Section of Neurobiology, University of California, San Diego JoVE 53290 Neuroscience चेतावनी, सिर रोका चूहे की उप-कॉर्टिकल मस्तिष्क संरचना के भीतर Juxtacellular निगरानी और स्थानीयकरण एकल के न्यूरॉन्स Jeffrey D. Moore1, Martin Deschênes2, David Kleinfeld1 1Department of Physics 0374, University of California, San Diego, 2Department of Psychiatry and Neuroscience, Centre de Recherche de l’Université Laval Robert-Giffard Neuroscience लंबे समय तक माउस ब्रेन इमेजिंग के लिए एक पॉलिश और प्रबलित विंडो पतला - खोपड़ी Andy Y. Shih1, Celine Mateo1, Patrick J. Drew2,3, Philbert S. Tsai1, David Kleinfeld1,4 1Department of Physics, University of California, San Diego, 2Department of Engineering Science and Mechanics, Pennsylvania State University, 3Department of Neurosurgery, Pennsylvania State University, 4Section of Neurobiology, University of California, San Diego JoVE 3742 Neuroscience
का निर्माण सेल आधारित न्यूरोट्रांसमीटर के ऑप्टिकल पता लगाने के लिए स्नायुसंचारी फ्लोरोसेंट इंजीनियर रिपोर्टर (CNiFERs) Emre Lacin1, Arnaud Muller2, Marian Fernando1, David Kleinfeld2,3, Paul A. Slesinger1 1Department of Neuroscience, Icahn School of Medicine at Mount Sinai, 2Department of Physics, University of California, San Diego, 3Section of Neurobiology, University of California, San Diego JoVE 53290 Neuroscience
चेतावनी, सिर रोका चूहे की उप-कॉर्टिकल मस्तिष्क संरचना के भीतर Juxtacellular निगरानी और स्थानीयकरण एकल के न्यूरॉन्स Jeffrey D. Moore1, Martin Deschênes2, David Kleinfeld1 1Department of Physics 0374, University of California, San Diego, 2Department of Psychiatry and Neuroscience, Centre de Recherche de l’Université Laval Robert-Giffard Neuroscience
लंबे समय तक माउस ब्रेन इमेजिंग के लिए एक पॉलिश और प्रबलित विंडो पतला - खोपड़ी Andy Y. Shih1, Celine Mateo1, Patrick J. Drew2,3, Philbert S. Tsai1, David Kleinfeld1,4 1Department of Physics, University of California, San Diego, 2Department of Engineering Science and Mechanics, Pennsylvania State University, 3Department of Neurosurgery, Pennsylvania State University, 4Section of Neurobiology, University of California, San Diego JoVE 3742 Neuroscience
