Elaine Dzierzak Department of Cell Biology and Genetics Erasmus University Medical Center Biography Publications Institution JoVE Articles Elaine Dzierzak has not added a biography. If you are Elaine Dzierzak and would like to personalize this page please email our Author Liaison for assistance. Publications Whole-mount Three-dimensional Imaging of Internally Localized Immunostained Cells Within Mouse Embryos Nature Protocols. 2012 | Pubmed ID: 22322215 Erythroid/myeloid Progenitors and Hematopoietic Stem Cells Originate from Distinct Populations of Endothelial Cells Cell Stem Cell. Dec, 2011 | Pubmed ID: 22136929 A Role for PML in Innate Immunity Genes & Cancer. Jan, 2011 | Pubmed ID: 21779477 Three-dimensional Imaging of Whole Midgestation Murine Embryos Shows an Intravascular Localization for All Hematopoietic Clusters Blood. Jun, 2011 | Pubmed ID: 21505195 CD41 is Developmentally Regulated and Differentially Expressed on Mouse Hematopoietic Stem Cells Blood. May, 2011 | Pubmed ID: 21415271 The EMT Regulator Zeb2/Sip1 is Essential for Murine Embryonic Hematopoietic Stem/progenitor Cell Differentiation and Mobilization Blood. May, 2011 | Pubmed ID: 21355089 Maintenance of HSC by Wnt5a Secreting AGM-derived Stromal Cell Line Experimental Hematology. Jan, 2011 | Pubmed ID: 20933051 Combinatorial Transcriptional Control in Blood Stem/progenitor Cells: Genome-wide Analysis of Ten Major Transcriptional Regulators Cell Stem Cell. Oct, 2010 | Pubmed ID: 20887958 Three-dimensional Cartography of Hematopoietic Clusters in the Vasculature of Whole Mouse Embryos Development (Cambridge, England). Nov, 2010 | Pubmed ID: 20876651 Preparation of Hematopoietic Stem and Progenitor Cells from the Human Placenta Current Protocols in Stem Cell Biology. Aug, 2010 | Pubmed ID: 20814938 The Placenta As a Haematopoietic Organ The International Journal of Developmental Biology. 2010 | Pubmed ID: 20711987 Placenta As a Source of Hematopoietic Stem Cells Trends in Molecular Medicine. Aug, 2010 | Pubmed ID: 20580607 In Vivo Imaging of Haematopoietic Cells Emerging from the Mouse Aortic Endothelium Nature. Mar, 2010 | Pubmed ID: 20154729 Human Placenta is a Potent Hematopoietic Niche Containing Hematopoietic Stem and Progenitor Cells Throughout Development Cell Stem Cell. Oct, 2009 | Pubmed ID: 19796619 Identification of Novel Regulators of Hematopoietic Stem Cell Development Through Refinement of Stem Cell Localization and Expression Profiling Blood. Nov, 2009 | Pubmed ID: 19794138 Opening Act in a Hematopoietic Program Blood. Jul, 2009 | Pubmed ID: 19589927 Ventral Embryonic Tissues and Hedgehog Proteins Induce Early AGM Hematopoietic Stem Cell Development Development (Cambridge, England). Aug, 2009 | Pubmed ID: 19570846 Hematopoietic Stem Cell Development is Dependent on Blood Flow Cell. May, 2009 | Pubmed ID: 19450519 Analysis of the Mouse Placenta As a Hematopoietic Stem Cell Niche Methods in Molecular Biology (Clifton, N.J.). 2009 | Pubmed ID: 19277584 Interleukin-1 Regulates Hematopoietic Progenitor and Stem Cells in the Midgestation Mouse Fetal Liver Haematologica. Apr, 2009 | Pubmed ID: 19229053 Runx1 is Required for the Endothelial to Haematopoietic Cell Transition but Not Thereafter Nature. Feb, 2009 | Pubmed ID: 19129762 Interleukin-1-mediated Hematopoietic Cell Regulation in the Aorta-gonad-mesonephros Region of the Mouse Embryo Blood. Dec, 2008 | Pubmed ID: 18805969 Analysis and Manipulation of Hematopoietic Progenitor and Stem Cells from Murine Embryonic Tissues Current Protocols in Stem Cell Biology. Jan, 2008 | Pubmed ID: 18770635 Efficient Hematopoietic Differentiation of Human Embryonic Stem Cells on Stromal Cells Derived from Hematopoietic Niches Cell Stem Cell. Jul, 2008 | Pubmed ID: 18593561 The Discovery of a Source of Adult Hematopoietic Cells in the Embryo Development (Cambridge, England). Aug, 2008 | Pubmed ID: 18567845 Impaired Embryonic Haematopoiesis Yet Normal Arterial Development in the Absence of the Notch Ligand Jagged1 The EMBO Journal. Jul, 2008 | Pubmed ID: 18528438 Fine-tuning of Hematopoietic Stem Cell Homeostasis: Novel Role for Ubiquitin Ligase Genes & Development. Apr, 2008 | Pubmed ID: 18413709 Stem Cell Researchers Find Their Niche Development (Cambridge, England). May, 2008 | Pubmed ID: 18408169 Of Lineage and Legacy: the Development of Mammalian Hematopoietic Stem Cells Nature Immunology. Feb, 2008 | Pubmed ID: 18204427 Embryonic Stromal Clones Reveal Developmental Regulators of Definitive Hematopoietic Stem Cells Proceedings of the National Academy of Sciences of the United States of America. Dec, 2007 | Pubmed ID: 18087045 Bcl-2 Expression and Apoptosis in the Regulation of Hematopoietic Stem Cells Leukemia & Lymphoma. Jan, 2007 | Pubmed ID: 17325844 Mesenchymal Lineage Potentials of Aorta-gonad-mesonephros Stromal Clones Haematologica. Sep, 2006 | Pubmed ID: 16956815 Promotion of Haematopoietic Activity in Embryonic Stem Cells by the Aorta-gonad-mesonephros Microenvironment Experimental Cell Research. Nov, 2006 | Pubmed ID: 16952354 Coordinated Acquisition of Inhibitory and Activating Receptors and Functional Properties by Developing Human Natural Killer Cells Blood. Dec, 2006 | Pubmed ID: 16902150 An Unexpected Role for IL-3 in the Embryonic Development of Hematopoietic Stem Cells Developmental Cell. Aug, 2006 | Pubmed ID: 16890157 Multipotential Hematopoietic Progenitor Cells from Embryos Developed in Vitro Engraft Unconditioned W41/W41 Neonatal MiceB Haematologica. Jun, 2005 | Pubmed ID: 15951285 Long-term Maintenance of Hematopoietic Stem Cells Does Not Require Contact with Embryo-derived Stromal Cells in Cocultures Stem Cells (Dayton, Ohio). Jun-Jul, 2005 | Pubmed ID: 15917480 Sca-1 Negatively Regulates Proliferation and Differentiation of Muscle Cells Developmental Biology. Jul, 2005 | Pubmed ID: 15901485 The Emergence of Definitive Hematopoietic Stem Cells in the Mammal Current Opinion in Hematology. May, 2005 | Pubmed ID: 15867575 The Murine Placenta Contains Hematopoietic Stem Cells Within the Vascular Labyrinth Region Developmental Cell. Mar, 2005 | Pubmed ID: 15737933 Mesenchymal Progenitor Cells Localize Within Hematopoietic Sites Throughout Ontogeny Development (Cambridge, England). Mar, 2005 | Pubmed ID: 15689383 Embryonic Beginnings of Adult Hematopoietic Stem Cells Haematologica. Jan, 2005 | Pubmed ID: 15642676 Hematopoietic Stem Cell Enrichment from the AGM Region of the Mouse Embryo Methods in Molecular Medicine. 2005 | Pubmed ID: 15492400 Generation of Murine Stromal Cell Lines: Models for the Microenvironment of the Embryonic Mouse Aorta-gonads-mesonephros Region Methods in Molecular Biology (Clifton, N.J.). 2005 | Pubmed ID: 15361662 GATA-2 Plays Two Functionally Distinct Roles During the Ontogeny of Hematopoietic Stem Cells The Journal of Experimental Medicine. Oct, 2004 | Pubmed ID: 15466621 Cell-cell Contact and Anatomical Compatibility in Stromal Cell-mediated HSC Support During Development Stem Cells (Dayton, Ohio). 2004 | Pubmed ID: 15153602 The Role of Apoptosis in the Development of AGM Hematopoietic Stem Cells Revealed by Bcl-2 Overexpression Blood. Jun, 2004 | Pubmed ID: 14962910 Ontogenic Emergence of Definitive Hematopoietic Stem Cells Current Opinion in Hematology. May, 2003 | Pubmed ID: 12690291 Impaired Hematopoiesis in Mice Lacking the Transcription Factor Sp3 Blood. Aug, 2003 | Pubmed ID: 12676787 Identification of 2 Novel Genes Developmentally Regulated in the Mouse Aorta-gonad-mesonephros Region Blood. Mar, 2003 | Pubmed ID: 12433684 Isolation and Analysis of Hematopoietic Stem Cells from Mouse Embryos Methods in Molecular Medicine. 2002 | Pubmed ID: 21437797 The Ly-6A (Sca-1) GFP Transgene is Expressed in All Adult Mouse Hematopoietic Stem Cells Stem Cells (Dayton, Ohio). 2002 | Pubmed ID: 12456959 Comparative Study of Stromal Cell Lines Derived from Embryonic, Fetal, and Postnatal Mouse Blood-forming Tissues Experimental Hematology. Oct, 2002 | Pubmed ID: 12384152 Hematopoietic Stem Cells and Their Precursors: Developmental Diversity and Lineage Relationships Immunological Reviews. Sep, 2002 | Pubmed ID: 12366688 Ectopic Expression of TAL-1 Protein in Ly-6E.1-htal-1 Transgenic Mice Induces Defects in B- and T-lymphoid Differentiation Blood. Jul, 2002 | Pubmed ID: 12091340 Hematopoietic Stem Cells Localize to the Endothelial Cell Layer in the Midgestation Mouse Aorta Immunity. May, 2002 | Pubmed ID: 12049719 Runx1 Expression Marks Long-term Repopulating Hematopoietic Stem Cells in the Midgestation Mouse Embryo Immunity. May, 2002 | Pubmed ID: 12049718 Embryonal Subregion-derived Stromal Cell Lines from Novel Temperature-sensitive SV40 T Antigen Transgenic Mice Support Hematopoiesis Journal of Cell Science. May, 2002 | Pubmed ID: 11973351 Ontogeny and Genetics of the Hemato/lymphopoietic System Current Opinion in Immunology. Apr, 2002 | Pubmed ID: 11869891 Expression of the Ly-6A (Sca-1) LacZ Transgene in Mouse Haematopoietic Stem Cells and Embryos British Journal of Haematology. Feb, 2002 | Pubmed ID: 11841445 Stromal Cell Lines from Mouse Aorta-gonads-mesonephros Subregions Are Potent Supporters of Hematopoietic Stem Cell Activity Blood. Feb, 2002 | Pubmed ID: 11830464 Isolation of Early Hematopoietic Stem Cells from Murine Yolk Sac and AGM Kelly Morgan1, Michael Kharas1, Elaine Dzierzak2, D. Gary Gilliland1,3 1Department of Hematology and Oncology, Brigham and Women's Hospital and Harvard Medical School, 2Department of Cell Biology and Genetics, Erasmus University Medical Center, 3Department of Medicine, Howard Hughes Medical Institute, Brigham and Women's Hospital and Harvard Medical School JoVE 789 Biology
Isolation of Early Hematopoietic Stem Cells from Murine Yolk Sac and AGM Kelly Morgan1, Michael Kharas1, Elaine Dzierzak2, D. Gary Gilliland1,3 1Department of Hematology and Oncology, Brigham and Women's Hospital and Harvard Medical School, 2Department of Cell Biology and Genetics, Erasmus University Medical Center, 3Department of Medicine, Howard Hughes Medical Institute, Brigham and Women's Hospital and Harvard Medical School JoVE 789 Biology