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In JoVE (1)
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Articles by Eric M. Johnson-Chavarria in JoVE
A Microfluidic-based Hydrodynamic Trap for Single Particles
Eric M. Johnson-Chavarria1, Melikhan Tanyeri2, Charles M. Schroeder1,2
1Center for Biophysics and Computational Biology, University of Illinois at Urbana-Champaign, 2Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign
In this article, we present a microfluidic-based method for particle confinement based on hydrodynamic flow. We demonstrate stable particle trapping at a fluid stagnation point using a feedback control mechanism, thereby enabling confinement and micromanipulation of arbitrary particles in an integrated microdevice.
Other articles by Eric M. Johnson-Chavarria on PubMed
Applied Physics Letters. May, 2010 | Pubmed ID: 20585593
Trapping and manipulation of microscale and nanoscale particles is demonstrated using the sole action of hydrodynamic forces. We developed an automated particle trap based on a stagnation point flow generated in a microfluidic device. The hydrodynamic trap enables confinement and manipulation of single particles in low viscosity (1-10 cP) aqueous solution. Using this method, we trapped microscale and nanoscale particles (100 nm-15 mum) for long time scales (minutes to hours). We demonstrate particle confinement to within 1 mum of the trap center, corresponding to a trap stiffness of approximately 10(-5)-10(-4) pNnm.