Friedrich Haag Institute of Immunology University Medical Center, Hamburg Biography Publications Institution JoVE Articles Friedrich Haag has not added a biography. If you are Friedrich Haag and would like to personalize this page please email our Author Liaison for assistance. Publications Tuning IL-2 Signaling by ADP-ribosylation of CD25 Scientific Reports. 2015 | Pubmed ID: 25753532 The Expression of CD39 on Regulatory T Cells is Genetically Driven and Further Upregulated at Sites of Inflammation Journal of Autoimmunity. Apr, 2015 | Pubmed ID: 25640206 Selection of Nanobodies That Block the Enzymatic and Cytotoxic Activities of the Binary Clostridium Difficile Toxin CDT Scientific Reports. 2015 | Pubmed ID: 25597743 Function of the Th17/interleukin-17A Immune Response in Murine Lupus Nephritis Arthritis & Rheumatology (Hoboken, N.J.). Feb, 2015 | Pubmed ID: 25385550 Identification and Analysis of ADP-ribosylated Proteins Current Topics in Microbiology and Immunology. 2015 | Pubmed ID: 25113886 ADP-ribosylation of P2X7: a Matter of Life and Death for Regulatory T Cells and Natural Killer T Cells Current Topics in Microbiology and Immunology. 2015 | Pubmed ID: 25048544 Functional Autoantibodies Against SSX-2 and NY-ESO-1 in Multiple Myeloma Patients After Allogeneic Stem Cell Transplantation Cancer Immunology, Immunotherapy : CII. Nov, 2014 | Pubmed ID: 25078248 Multidimensional Scaling Analysis Identifies Pathological and Prognostically Relevant Profiles of Circulating T-cells in Chronic Lymphocytic Leukemia International Journal of Cancer. Journal International Du Cancer. Nov, 2014 | Pubmed ID: 24723150 In Vivo Near-infrared Fluorescence Targeting of T Cells: Comparison of Nanobodies and Conventional Monoclonal Antibodies Contrast Media & Molecular Imaging. Mar-Apr, 2014 | Pubmed ID: 24523058 Mucolipidosis II-related Mutations Inhibit the Exit from the Endoplasmic Reticulum and Proteolytic Cleavage of GlcNAc-1-phosphotransferase Precursor Protein (GNPTAB) Human Mutation. Mar, 2014 | Pubmed ID: 24375680 Technical Advance: a New Cell Preparation Strategy That Greatly Improves the Yield of Vital and Functional Tregs and NKT Cells Journal of Leukocyte Biology. Mar, 2014 | Pubmed ID: 24212099 Peripheral Blood Biomarkers for the Characterization of Alloimmune Reactivity After Pediatric Liver Transplantation Pediatric Transplantation. Dec, 2013 | Pubmed ID: 24164827 CD38 Controls the Innate Immune Response Against Listeria Monocytogenes Infection and Immunity. Nov, 2013 | Pubmed ID: 23980105 The Art of Blocking ADP-ribosyltransferases (ARTs): Nanobodies As Experimental and Therapeutic Tools to Block Mammalian and Toxin ARTs The FEBS Journal. Aug, 2013 | Pubmed ID: 23627412 CD8-β ADP-ribosylation Affects CD8(+) T-cell Function European Journal of Immunology. Jul, 2013 | Pubmed ID: 23575529 Cytokine Concentrations and Regulatory T Cells in Living Donor and Deceased Donor Liver Transplant Recipients Pediatric Transplantation. Mar, 2013 | Pubmed ID: 23331338 Expansion of HIV-specific T Follicular Helper Cells in Chronic HIV Infection The Journal of Clinical Investigation. Sep, 2012 | Pubmed ID: 22922259 Alternative Splicing of the N-terminal Cytosolic and Transmembrane Domains of P2X7 Controls Gating of the Ion Channel by ADP-ribosylation PloS One. 2012 | Pubmed ID: 22848454 Extracellular NAD(+): a Danger Signal Hindering Regulatory T Cells Microbes and Infection / Institut Pasteur. Nov, 2012 | Pubmed ID: 22634347 Longitudinal Analysis of Tetanus- and Influenza-specific IgG Antibodies in Myeloma Patients Clinical & Developmental Immunology. 2012 | Pubmed ID: 22481961 Protective Role for CCR5 in Murine Lupus Nephritis American Journal of Physiology. Renal Physiology. Jun, 2012 | Pubmed ID: 22442210 Antigen-specificity of Oligoclonal Abnormal Protein Bands in Multiple Myeloma After Allogeneic Stem Cell Transplantation Cancer Immunology, Immunotherapy : CII. Oct, 2012 | Pubmed ID: 22350072 Patients with Multiple Myeloma Develop SOX2-specific Autoantibodies After Allogeneic Stem Cell Transplantation Clinical & Developmental Immunology. 2011 | Pubmed ID: 22190969 Signal-peptide-peptidase-like 2a (SPPL2a) is Targeted to Lysosomes/late Endosomes by a Tyrosine Motif in Its C-terminal Tail FEBS Letters. Oct, 2011 | Pubmed ID: 21896273 Monoclonal Antibodies for the Identification and Purification of VNAR Domains and IgNAR Immunoglobulins from the Horn Shark Heterodontus Francisci Hybridoma (2005). Aug, 2011 | Pubmed ID: 21851231 Strategies for the Identification of Arginine ADP-ribosylation Sites Journal of Proteomics. Dec, 2011 | Pubmed ID: 21784185 Transgenic Overexpression of Toxin-related Ecto-ADP-ribosyltransferase ART2.2 Sensitizes T Cells but Not B Cells to NAD-induced Cell Death Molecular Immunology. Sep, 2011 | Pubmed ID: 21641039 Characterisation of a Novel Glycosylphosphatidylinositol-anchored Mono-ADP-ribosyltransferase Isoform in Ovary Cells European Journal of Cell Biology. Aug, 2011 | Pubmed ID: 21616557 Compartmentation of NAD+-dependent Signalling FEBS Letters. Jun, 2011 | Pubmed ID: 21443875 Single-domain Llama Antibodies As Specific Intracellular Inhibitors of SpvB, the Actin ADP-ribosylating Toxin of Salmonella Typhimurium FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Feb, 2011 | Pubmed ID: 20940265 ADP-ribosylation of Arginine Amino Acids. Jul, 2011 | Pubmed ID: 20652610 Extracellular NAD+ Shapes the Foxp3+ Regulatory T Cell Compartment Through the ART2-P2X7 Pathway The Journal of Experimental Medicine. Nov, 2010 | Pubmed ID: 20975043 Quantitative Magnetic Resonance Imaging of Enzyme Activity on the Cell Surface: in Vitro and in Vivo Monitoring of ADP-ribosyltransferase 2 on T Cells Molecular Imaging. Aug, 2010 | Pubmed ID: 20643024 Proinflammatory and Osteoclastogenic Effects of Beta-tricalciumphosphate and Hydroxyapatite Particles on Human Mononuclear Cells in Vitro Biomaterials. Oct, 2009 | Pubmed ID: 19577291 Differential Regulation of P2X7 Receptor Activation by Extracellular Nicotinamide Adenine Dinucleotide and Ecto-ADP-ribosyltransferases in Murine Macrophages and T Cells Journal of Immunology (Baltimore, Md. : 1950). Jul, 2009 | Pubmed ID: 19542469 Single Domain Antibodies: Promising Experimental and Therapeutic Tools in Infection and Immunity Medical Microbiology and Immunology. Aug, 2009 | Pubmed ID: 19529959 Basal and Inducible Expression of the Thiol-sensitive ART2.1 Ecto-ADP-ribosyltransferase in Myeloid and Lymphoid Leukocytes Purinergic Signalling. Sep, 2009 | Pubmed ID: 19404775 Activation of the P2X7 Ion Channel by Soluble and Covalently Bound Ligands Purinergic Signalling. Jun, 2009 | Pubmed ID: 19255877 Characterisation of the R276A Gain-of-function Mutation in the Ectodomain of Murine P2X7 Purinergic Signalling. Jun, 2009 | Pubmed ID: 19234763 NAD+ and ATP Released from Injured Cells Induce P2X7-dependent Shedding of CD62L and Externalization of Phosphatidylserine by Murine T Cells Journal of Immunology (Baltimore, Md. : 1950). Mar, 2009 | Pubmed ID: 19234185 Emerging Roles of NAD+ and Its Metabolites in Cell Signaling Science Signaling. 2009 | Pubmed ID: 19211509 ATP Induces P2X7 Receptor-independent Cytokine and Chemokine Expression Through P2X1 and P2X3 Receptors in Murine Mast Cells Journal of Leukocyte Biology. Apr, 2009 | Pubmed ID: 19164130 High Sensitivity of Intestinal CD8+ T Cells to Nucleotides Indicates P2X7 As a Regulator for Intestinal T Cell Responses Journal of Immunology (Baltimore, Md. : 1950). Sep, 2008 | Pubmed ID: 18768840 Hierarchy of Nonhomologous End-joining, Single-strand Annealing and Gene Conversion at Site-directed DNA Double-strand Breaks Nucleic Acids Research. Jul, 2008 | Pubmed ID: 18539610 Mammalian ADP-ribosyltransferases and ADP-ribosylhydrolases Frontiers in Bioscience : a Journal and Virtual Library. 2008 | Pubmed ID: 18508690 The Cellular Localization of Autotaxin Impacts on Its Biological Functions in Human Thyroid Carcinoma Cells Oncology Reports. Jun, 2008 | Pubmed ID: 18497954 ADP-ribosylation at R125 Gates the P2X7 Ion Channel by Presenting a Covalent Ligand to Its Nucleotide Binding Site FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Mar, 2008 | Pubmed ID: 17928361 Monitoring the Expression of Purinoceptors and Nucleotide-metabolizing Ecto-enzymes with Antibodies Directed Against Proteins in Native Conformation Purinergic Signalling. Sep, 2007 | Pubmed ID: 18404449 Extracellular NAD and ATP: Partners in Immune Cell Modulation Purinergic Signalling. Mar, 2007 | Pubmed ID: 18404420 Lipopolysaccharide, IFN-gamma, and IFN-beta Induce Expression of the Thiol-sensitive ART2.1 Ecto-ADP-ribosyltransferase in Murine Macrophages Journal of Immunology (Baltimore, Md. : 1950). Nov, 2007 | Pubmed ID: 17947697 CD83 Modulates B Cell Function in Vitro: Increased IL-10 and Reduced Ig Secretion by CD83Tg B Cells PloS One. 2007 | Pubmed ID: 17710154 Autophagic Cell Death Induced by TrkA Receptor Activation in Human Glioblastoma Cells Journal of Neurochemistry. Oct, 2007 | Pubmed ID: 17635673 NAD+ Released During Inflammation Participates in T Cell Homeostasis by Inducing ART2-mediated Death of Naive T Cells in Vivo Journal of Immunology (Baltimore, Md. : 1950). Jul, 2007 | Pubmed ID: 17579037 Single Domain Antibodies from Llama Effectively and Specifically Block T Cell Ecto-ADP-ribosyltransferase ART2.2 in Vivo FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Nov, 2007 | Pubmed ID: 17575259 Chemokine Receptor CXCR3 Mediates T Cell Recruitment and Tissue Injury in Nephrotoxic Nephritis in Mice Journal of the American Society of Nephrology : JASN. Jul, 2007 | Pubmed ID: 17538187 The Structure of Human ADP-ribosylhydrolase 3 (ARH3) Provides Insights into the Reversibility of Protein ADP-ribosylation Proceedings of the National Academy of Sciences of the United States of America. Oct, 2006 | Pubmed ID: 17015823 ADP-ribosylation of Membrane Proteins: Unveiling the Secrets of a Crucial Regulatory Mechanism in Mammalian Cells Annals of Medicine. 2006 | Pubmed ID: 16720433 Targeted Disruption of CD38 Accelerates Autoimmune Diabetes in NOD/Lt Mice by Enhancing Autoimmunity in an ADP-ribosyltransferase 2-dependent Fashion Journal of Immunology (Baltimore, Md. : 1950). Apr, 2006 | Pubmed ID: 16585549 Up-regulation of the T Cell Quiescence Factor KLF2 in a Leukaemic T-cell Line After Expression of the Inositol 5'-phosphatase SHIP-1 British Journal of Haematology. Dec, 2005 | Pubmed ID: 16351639 Use of Genetic Immunization to Raise Antibodies Recognizing Toxin-related Cell Surface ADP-ribosyltransferases in Native Conformation Cellular Immunology. Jul-Aug, 2005 | Pubmed ID: 16271711 In Silico Characterization of the Family of PARP-like Poly(ADP-ribosyl)transferases (pARTs) BMC Genomics. 2005 | Pubmed ID: 16202152 Characterization of Multiple Alleles of the T-cell Differentiation Marker ART2 (RT6) in Inbred and Wild Rats Immunogenetics. Nov, 2005 | Pubmed ID: 16195877 A Panel of Monoclonal Antibodies Recognizing GPI-anchored ADP-ribosyltransferase ART4, the Carrier of the Dombrock Blood Group Antigens Cellular Immunology. Jul-Aug, 2005 | Pubmed ID: 16168396 Probing the Expression and Function of the P2X7 Purinoceptor with Antibodies Raised by Genetic Immunization Cellular Immunology. Jul-Aug, 2005 | Pubmed ID: 16165114 Expression of Insulin-like Factor 3 Protein in the Rat Testis During Fetal and Postnatal Development and in Relation to Cryptorchidism Induced by in Utero Exposure to Di (n-Butyl) Phthalate Endocrinology. Oct, 2005 | Pubmed ID: 16037377 CD38 Controls ADP-ribosyltransferase-2-catalyzed ADP-ribosylation of T Cell Surface Proteins Journal of Immunology (Baltimore, Md. : 1950). Mar, 2005 | Pubmed ID: 15749861 A PKR-like Eukaryotic Initiation Factor 2alpha Kinase from Zebrafish Contains Z-DNA Binding Domains Instead of DsRNA Binding Domains Proceedings of the National Academy of Sciences of the United States of America. Feb, 2005 | Pubmed ID: 15659550 Activity and Specificity of Toxin-related Mouse T Cell Ecto-ADP-ribosyltransferase ART2.2 Depends on Its Association with Lipid Rafts Blood. May, 2005 | Pubmed ID: 15657180 Mono-allelic Expression of the IGF-I Receptor Does Not Affect IGF Responses in Human Fibroblasts European Journal of Endocrinology / European Federation of Endocrine Societies. Oct, 2004 | Pubmed ID: 15476454 Ecto-ADP-ribosyltransferases (ARTs): Emerging Actors in Cell Communication and Signaling Current Medicinal Chemistry. Apr, 2004 | Pubmed ID: 15078170 T-cell Survival Regulator LKLF is Not Involved in Inappropriate Apoptosis of Diabetes-prone BBDP Rat T Cells Annals of the New York Academy of Sciences. Dec, 2003 | Pubmed ID: 15033788 Triggering of T-cell Apoptosis by Toxin-related Ecto-ADP-ribosyltransferase ART2 Annals of the New York Academy of Sciences. Dec, 2003 | Pubmed ID: 15033737 NAD-induced T Cell Death: ADP-ribosylation of Cell Surface Proteins by ART2 Activates the Cytolytic P2X7 Purinoceptor Immunity. Oct, 2003 | Pubmed ID: 14563321 Effects of Mitoxantrone on Multiple Sclerosis Patients' Lymphocyte Subpopulations and Production of Immunoglobulin, TNF-alpha and IL-10 European Neurology. 2003 | Pubmed ID: 12646755 Flow Cytometric and Immunoblot Assays for Cell Surface ADP-ribosylation Using a Monoclonal Antibody Specific for Ethenoadenosine Analytical Biochemistry. Mar, 2003 | Pubmed ID: 12633608 T Cells of Different Developmental Stages Differ in Sensitivity to Apoptosis Induced by Extracellular NAD Developmental Immunology. Dec, 2002 | Pubmed ID: 15144016 Cutting Edge: a Natural P451L Mutation in the Cytoplasmic Domain Impairs the Function of the Mouse P2X7 Receptor Journal of Immunology (Baltimore, Md. : 1950). Oct, 2002 | Pubmed ID: 12370338 Generation and Characterization of Ecto-ADP-ribosyltransferase ART2.1/ART2.2-deficient Mice Molecular and Cellular Biology. Nov, 2002 | Pubmed ID: 12370300 Structure of the Ecto-ADP-ribosyl Transferase ART2.2 from Rat Journal of Molecular Biology. Sep, 2002 | Pubmed ID: 12270706 Independent Integration of Rodent Identifier (ID) Elements into Orthologous Sites of Some RT6 Alleles of Rattus Norvegicus and Rattus Rattus Journal of Molecular Evolution. Sep, 2002 | Pubmed ID: 12187378 Effects of Interleukin-2 Plus Highly Active Antiretroviral Therapy on HIV-1 Replication and Proviral DNA (COSMIC Trial) AIDS (London, England). Jul, 2002 | Pubmed ID: 12131185 Expression, Purification, Crystallization and Preliminary X-ray Analysis of Rat Ecto-ADP-ribosyltransferase 2 (ART2.2) Acta Crystallographica. Section D, Biological Crystallography. Jul, 2002 | Pubmed ID: 12077446 The Family of Toxin-related Ecto-ADP-ribosyltransferases in Humans and the Mouse Protein Science : a Publication of the Protein Society. Jul, 2002 | Pubmed ID: 12070318 Mono-ADP-ribosyltransferases in Human Monocytes: Regulation by Lipopolysaccharide The Biochemical Journal. Mar, 2002 | Pubmed ID: 11879200 Complex Regulation of the Human Gene for the Z-DNA Binding Protein DLM-1 Nucleic Acids Research. Feb, 2002 | Pubmed ID: 11842111 التحقق من Nanobody والجسم المضاد القائم Peter Bannas*1, Alexander Lenz*1,2, Valentin Kunick1,2, William Fumey1,2, Björn Rissiek2, Joanna Schmid1,2, Friedrich Haag2, Axel Leingärtner3, Martin Trepel4, Gerhard Adam1, Friedrich Koch-Nolte2 1Department of Diagnostic and Interventional Radiology, University Medical Center, Hamburg, 2Institute of Immunology, University Medical Center, Hamburg, 3University Cancer Center Hamburg, University Medical Center, Hamburg, 4Department of Oncology and Hematology, University Medical Center, Hamburg Medicine
التحقق من Nanobody والجسم المضاد القائم Peter Bannas*1, Alexander Lenz*1,2, Valentin Kunick1,2, William Fumey1,2, Björn Rissiek2, Joanna Schmid1,2, Friedrich Haag2, Axel Leingärtner3, Martin Trepel4, Gerhard Adam1, Friedrich Koch-Nolte2 1Department of Diagnostic and Interventional Radiology, University Medical Center, Hamburg, 2Institute of Immunology, University Medical Center, Hamburg, 3University Cancer Center Hamburg, University Medical Center, Hamburg, 4Department of Oncology and Hematology, University Medical Center, Hamburg Medicine