HELEN REEVES Clinical and Translational Research Institute Newcastle University Biography Publications Institution JoVE Articles HELEN REEVES Helen Reeves graduated from Nottingham Medical school in 1990, moving shortly afterwards to Newcastle-upon-Tyne under the mentorship of Professor Oliver James. She completed a PhD studying cell signaling pathways in liver fibrosis and then worked as a post-doctoral scientist with Professor Scott Friedman at Mount Sinai Medical School in New York, studying aspects of the molecular pathogenesis of cancers. Presently she is Professor of Liver Cancer in the Newcastle University Center for Cancer and is the clinical lead for the care of patients with hepatocellular carcinoma in North East England and Cumbria. She has been a scientific committee member for the British Association for Cancer Research and the European Association for Study of the Liver. She is an active member of the HCC-UK Committee. Her main research focus is on HCC in patients with NAFLD and in the development of clinically relevant biomarkers. She also has a keen interest in the promotion of education and training of young scientific investigators and clinical researchers. She has a program grant from CRUK centred on exploring the roles of neutrophils in liver cancer. She is also the PI for the Liver Cancer focused Accelerator award, jointly funded by CRUK, FC AECC and AIRC entitled ‘HUNTER: Hepatocellular Carcinoma Expediter Network’. Publications Cell-free DNA TAPS Provides Multimodal Information for Early Cancer Detection Science Advances. Sep, 2021 | Pubmed ID: 34516908 Key Features of the Environment Promoting Liver Cancer in the Absence of Cirrhosis Scientific Reports. Aug, 2021 | Pubmed ID: 34408183 Anti-miR-518d-5p Overcomes Liver Tumor Cell Death Resistance Through Mitochondrial Activity Cell Death & Disease. 05, 2021 | Pubmed ID: 34050139 Combined Hepatocellular-cholangiocarcinoma - More Questions Than Answers Liver International : Official Journal of the International Association for the Study of the Liver. 06, 2021 | Pubmed ID: 34002474 Molecular Characterisation of Hepatocellular Carcinoma in Patients with Non-alcoholic Steatohepatitis Journal of Hepatology. Oct, 2021 | Pubmed ID: 33992698 NAFLD-Associated HCC: Progress and Opportunities Journal of Hepatocellular Carcinoma. Month, 2021 | Pubmed ID: 33854987 A Role in the Genetic Predisposition to NAFLD-HCC? Cancers. Mar, 2021 | Pubmed ID: 33808740 Neutrophils Induce Paracrine Telomere Dysfunction and Senescence in ROS-dependent Manner The EMBO Journal. May, 2021 | Pubmed ID: 33764576 Hepatocellular Carcinoma in Non-alcoholic Fatty Liver Disease-a Review of an Emerging Challenge Facing Clinicians Hepatobiliary Surgery and Nutrition. Jan, 2021 | Pubmed ID: 33575290 Treatment Strategies for Early Stage Hepatocellular Carcinoma: a Systematic Review and Network Meta-analysis of Randomised Clinical Trials HPB : the Official Journal of the International Hepato Pancreato Biliary Association. Apr, 2021 | Pubmed ID: 33309569 High Subcutaneous Adipose Tissue Density Correlates Negatively with Survival in Patients with Hepatocellular Carcinoma Liver International : Official Journal of the International Association for the Study of the Liver. 04, 2021 | Pubmed ID: 33280219 Non-invasive Stratification of Hepatocellular Carcinoma Risk in Non-alcoholic Fatty Liver Using Polygenic Risk Scores Journal of Hepatology. 04, 2021 | Pubmed ID: 33248170 Development of a Novel Inflammation-Based Index for Hepatocellular Carcinoma Liver Cancer. Apr, 2020 | Pubmed ID: 32399431 Selective DNA-PKcs Inhibition Extends the Therapeutic Index of Localized Radiotherapy and Chemotherapy The Journal of Clinical Investigation. 01, 2020 | Pubmed ID: 31581151 From NASH to HCC: Current Concepts and Future Challenges Nature Reviews. Gastroenterology & Hepatology. 07, 2019 | Pubmed ID: 31028350 Rare Pathogenic Variants Predispose to Hepatocellular Carcinoma in Nonalcoholic Fatty Liver Disease Scientific Reports. 03, 2019 | Pubmed ID: 30842500 The CCR2 Macrophage Subset Promotes Pathogenic Angiogenesis for Tumor Vascularization in Fibrotic Livers Cellular and Molecular Gastroenterology and Hepatology. Month, 2019 | Pubmed ID: 30704985 Weighing the Benefits of Hepatocellular Carcinoma Surveillance Against Potential Harms Journal of Hepatocellular Carcinoma. Month, 2019 | Pubmed ID: 30666302 Fatty Liver Disease and Hepatocellular Carcinoma: The Pathologist's View Advances in Experimental Medicine and Biology. Month, 2018 | Pubmed ID: 30362090 Reply to 'Comment on 'Circulating Neutrophils in Patients with Hepatocellular Carcinoma" British Journal of Cancer. 09, 2018 | Pubmed ID: 30206368 Liquid Biopsy for Liver Diseases Gut. 12, 2018 | Pubmed ID: 30177542 Data Set for the Reporting of Intrahepatic Cholangiocarcinoma, Perihilar Cholangiocarcinoma and Hepatocellular Carcinoma: Recommendations from the International Collaboration on Cancer Reporting (ICCR) Histopathology. Sep, 2018 | Pubmed ID: 29573451 Neutrophils: Driving Progression and Poor Prognosis in Hepatocellular Carcinoma? British Journal of Cancer. 01, 2018 | Pubmed ID: 29123264 The Mitochondrial Negative Regulator MCJ is a Therapeutic Target for Acetaminophen-induced Liver Injury Nature Communications. 12, 2017 | Pubmed ID: 29233977 NAFLD-which Patients Should Have Hepatocellular Carcinoma Surveillance? Hepatobiliary Surgery and Nutrition. Oct, 2017 | Pubmed ID: 29152488 Telomerase Reverse Transcriptase Germline Mutations and Hepatocellular Carcinoma in Patients with Nonalcoholic Fatty Liver Disease Cancer Medicine. Aug, 2017 | Pubmed ID: 28677271 MBOAT7 Rs641738 Variant and Hepatocellular Carcinoma in Non-cirrhotic Individuals Scientific Reports. 07, 2017 | Pubmed ID: 28674415 Opposite Effects of a Glucokinase Activator and Metformin on Glucose-regulated Gene Expression in Hepatocytes Diabetes, Obesity & Metabolism. 08, 2017 | Pubmed ID: 28206714 Design and Synthesis of Biphenyl and Biphenyl Ether Inhibitors of Sulfatases Chemical Science. Apr, 2016 | Pubmed ID: 28660059 Sulfatase-2: a Prognostic Biomarker and Candidate Therapeutic Target in Patients with Pancreatic Ductal Adenocarcinoma British Journal of Cancer. 09, 2016 | Pubmed ID: 27560551 Combination PARP and HDAC Inhibition As a Therapeutic Strategy Targeting Liver Cancer Stem Cells? Chinese Clinical Oncology. Oct, 2016 | Pubmed ID: 27164859 Imagestream Detection and Characterisation of Circulating Tumour Cells - A Liquid Biopsy for Hepatocellular Carcinoma? Journal of Hepatology. 08, 2016 | Pubmed ID: 27132171 Hepatocellular Carcinoma in Obesity, Type 2 Diabetes, and NAFLD Digestive Diseases and Sciences. May, 2016 | Pubmed ID: 26921078 Assessment of the Hong Kong Liver Cancer Staging System in Europe Liver International : Official Journal of the International Association for the Study of the Liver. 06, 2016 | Pubmed ID: 26677809 High-resolution Imaging for the Detection and Characterisation of Circulating Tumour Cells from Patients with Oesophageal, Hepatocellular, Thyroid and Ovarian Cancers International Journal of Cancer. Jan, 2016 | Pubmed ID: 26178530 Hepatocellular Carcinoma: Optimal Staging Impacts Survival Gastroenterology. Jun, 2015 | Pubmed ID: 25921373 Regioselective Sulfamoylation at Low Temperature Enables Concise Syntheses of Putative Small Molecule Inhibitors of Sulfatases Organic & Biomolecular Chemistry. May, 2015 | Pubmed ID: 25858034 Regular Exercise Decreases Liver Tumors Development in Hepatocyte-specific PTEN-deficient Mice Independently of Steatosis Journal of Hepatology. Jun, 2015 | Pubmed ID: 25623824 Reply To: HCC and Liver Disease Risk in Homozygous PNPLA3 P.I148M Carriers Approach Monogenic Inheritance Journal of Hepatology. Apr, 2015 | Pubmed ID: 25559329 DNA-PK-A Candidate Driver of Hepatocarcinogenesis and Tissue Biomarker That Predicts Response to Treatment and Survival Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Feb, 2015 | Pubmed ID: 25480831 TM6SF2 Rs58542926 Influences Hepatic Fibrosis Progression in Patients with Non-alcoholic Fatty Liver Disease Nature Communications. Jun, 2014 | Pubmed ID: 24978903 Reply to "Hepatocellular Carcinoma and the Newcastle-upon-Tyne Area" Journal of Hepatology. Jun, 2014 | Pubmed ID: 24602766 The Detection of Hepatocellular Carcinoma Using a Prospectively Developed and Validated Model Based on Serological Biomarkers Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology. Jan, 2014 | Pubmed ID: 24220911 Hepatocellular Cancer: the Impact of Obesity, Type 2 Diabetes and a Multidisciplinary Team Journal of Hepatology. Jan, 2014 | Pubmed ID: 23978719 The Rate of Production of Uric Acid by Hepatocytes is a Sensitive Index of Compromised Cell ATP Homeostasis American Journal of Physiology. Endocrinology and Metabolism. Nov, 2013 | Pubmed ID: 24045866 Post-transcriptional Activation of PPAR Alpha by KLF6 in Hepatic Steatosis Journal of Hepatology. May, 2013 | Pubmed ID: 23353867 Glucokinase Links Krüppel-like Factor 6 to the Regulation of Hepatic Insulin Sensitivity in Nonalcoholic Fatty Liver Disease Hepatology (Baltimore, Md.). Apr, 2012 | Pubmed ID: 22095588 The Role of Tobacco-derived Carcinogens in Pancreas Cancer ISRN Oncology. Month, 2011 | Pubmed ID: 22084727 A Proteomic Strategy to Identify Novel Serum Biomarkers for Liver Cirrhosis and Hepatocellular Cancer in Individuals with Fatty Liver Disease BMC Cancer. Aug, 2009 | Pubmed ID: 19656391 AFP, PIVKAII, GP3, SCCA-1 and Follisatin As Surveillance Biomarkers for Hepatocellular Cancer in Non-alcoholic and Alcoholic Fatty Liver Disease BMC Cancer. Jul, 2008 | Pubmed ID: 18638391 The Kruppel-like Factor 6 Genotype is Associated with Fibrosis in Nonalcoholic Fatty Liver Disease Gastroenterology. Jul, 2008 | Pubmed ID: 18515091 A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma Marco Y. W. Zaki*1,2, Shishir Shetty*2, Alex L. Wilkinson2, Daniel A. Patten2, Fiona Oakley*3, Helen Reeves*4,5 1Department of Biochemistry, Faculty of Pharmacy, Minia University, 2National Institute for Health Research Birmingham Liver Biomedical Research Unit and Centre for Liver and Gastrointestinal Research, Institute of Immunology and Immunotherapy, University of Birmingham, 3Newcastle Fibrosis Research Group, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, 4Newcastle University Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, 5The Liver Unit, Department of Medicine, Freeman Hospital, Newcastle-upon-Tyne Hospitals NHS Foundation Trust JoVE 62868 Cancer Research
A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma Marco Y. W. Zaki*1,2, Shishir Shetty*2, Alex L. Wilkinson2, Daniel A. Patten2, Fiona Oakley*3, Helen Reeves*4,5 1Department of Biochemistry, Faculty of Pharmacy, Minia University, 2National Institute for Health Research Birmingham Liver Biomedical Research Unit and Centre for Liver and Gastrointestinal Research, Institute of Immunology and Immunotherapy, University of Birmingham, 3Newcastle Fibrosis Research Group, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, 4Newcastle University Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, 5The Liver Unit, Department of Medicine, Freeman Hospital, Newcastle-upon-Tyne Hospitals NHS Foundation Trust JoVE 62868 Cancer Research