Isabelle Broutin Laboratoire de Cristallographie & RMN Biologiques CNRS & Université Paris Descartes Biography Publications Institution JoVE Articles Isabelle Broutin has not added a biography. If you are Isabelle Broutin and would like to personalize this page please email our Author Liaison for assistance. Publications Multiple Mutations Lead to MexXY-OprM-dependent Aminoglycoside Resistance in Clinical Strains of Pseudomonas Aeruginosa Antimicrobial Agents and Chemotherapy. Jan, 2014 | Pubmed ID: 24145539 Contribution of Asparagine 346 Residue to the Carbapenemase Activity of CMY-2 β-lactamase FEMS Microbiology Letters. Aug, 2013 | Pubmed ID: 23763375 Hoechst Likes to Play Hide and Seek...use It with Caution! Analytical Biochemistry. Sep, 2013 | Pubmed ID: 23743152 Unusual Binding of Grb2 Protein to a Bivalent Polyproline-ligand Immobilized on a SPR Sensor: Intermolecular Bivalent Binding Biochimica Et Biophysica Acta. Feb, 2013 | Pubmed ID: 23159538 Stoichiometry of the MexA-OprM Binding, As Investigated by Blue Native Gel Electrophoresis Electrophoresis. Apr, 2012 | Pubmed ID: 22589107 Photo-induced Proton Gradients for the in Vitro Investigation of Bacterial Efflux Pumps Scientific Reports. 2012 | Pubmed ID: 22400101 Activity Monitoring of Functional OprM Using a Biomimetic Microfluidic Device The Analyst. Feb, 2012 | Pubmed ID: 22215439 Targeting the Proangiogenic VEGF-VEGFR Protein-protein Interface with Drug-like Compounds by in Silico and in Vitro Screening Chemistry & Biology. Dec, 2011 | Pubmed ID: 22195565 INF2 Mutations in Charcot-Marie-Tooth Disease with Glomerulopathy The New England Journal of Medicine. Dec, 2011 | Pubmed ID: 22187985 Novel NOBOX Loss-of-function Mutations Account for 6.2% of Cases in a Large Primary Ovarian Insufficiency Cohort Human Mutation. Oct, 2011 | Pubmed ID: 21837770 Mutations in INF2 Are a Major Cause of Autosomal Dominant Focal Segmental Glomerulosclerosis Journal of the American Society of Nephrology : JASN. Feb, 2011 | Pubmed ID: 21258034 Structural Characterization of the Stem-stem Dimerization Interface Between Prolactin Receptor Chains Complexed with the Natural Hormone Journal of Molecular Biology. Nov, 2010 | Pubmed ID: 20875426 Structural and Dynamical Insights into the Opening Mechanism of P. Aeruginosa OprM Channel Structure (London, England : 1993). Mar, 2010 | Pubmed ID: 20399187 Crystal Structure of an Affinity-matured Prolactin Complexed to Its Dimerized Receptor Reveals the Topology of Hormone Binding Site 2 The Journal of Biological Chemistry. Mar, 2010 | Pubmed ID: 20053995 NKX2-1 Mutations Leading to Surfactant Protein Promoter Dysregulation Cause Interstitial Lung Disease in "Brain-Lung-Thyroid Syndrome" Human Mutation. Feb, 2010 | Pubmed ID: 20020530 Molecular Determinants of Grb14-mediated Inhibition of Insulin Signaling Molecular Endocrinology (Baltimore, Md.). Jul, 2009 | Pubmed ID: 19359342 Enzyme Structural Plasticity and the Emergence of Broad-spectrum Antibiotic Resistance EMBO Reports. Apr, 2008 | Pubmed ID: 18292754 A Non-canonical Grb2-PLC-gamma1-Sos Cascade Triggered by Lipovitellin 1, an Apolipoprotein B Homologue Cellular Signalling. Dec, 2007 | Pubmed ID: 17869481 Structural and Thermodynamic Bases for the Design of Pure Prolactin Receptor Antagonists: X-ray Structure of Del1-9-G129R-hPRL The Journal of Biological Chemistry. Nov, 2007 | Pubmed ID: 17785459 High Affinity Grb2-SH3 Domain Ligand Incorporating Cbeta-substituted Prolines in a Sos-derived Decapeptide Bioorganic & Medicinal Chemistry. Feb, 2007 | Pubmed ID: 17113302 Expression, Purification, Crystallization and Preliminary X-ray Studies of the Outer Membrane Efflux Proteins OprM and OprN from Pseudomonas Aeruginosa Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. Mar, 2005 | Pubmed ID: 16511029 Solution NMR Structure of the SH3 Domain of Human Nephrocystin and Analysis of a Mutation-causing Juvenile Nephronophthisis Proteins. May, 2005 | Pubmed ID: 15723349 Changes in Structural Dynamics of the Grb2 Adaptor Protein Upon Binding of Phosphotyrosine Ligand to Its SH2 Domain Biochimica Et Biophysica Acta. Jul, 2004 | Pubmed ID: 15210125 The PIR Domain of Grb14 is an Intrinsically Unstructured Protein: Implication in Insulin Signaling FEBS Letters. Nov, 2003 | Pubmed ID: 14623073 Crystal Structures of the SH2 Domain of Grb2: Highlight on the Binding of a New High-affinity Inhibitor Journal of Molecular Biology. Feb, 2002 | Pubmed ID: 11827484 In vitro Investigation of the MexAB Efflux Pump From Pseudomonas aeruginosa Alice Verchère1, Manuela Dezi1, Isabelle Broutin1, Martin Picard1 1Laboratoire de Cristallographie & RMN Biologiques, CNRS & Université Paris Descartes JoVE 50894 Biology
In vitro Investigation of the MexAB Efflux Pump From Pseudomonas aeruginosa Alice Verchère1, Manuela Dezi1, Isabelle Broutin1, Martin Picard1 1Laboratoire de Cristallographie & RMN Biologiques, CNRS & Université Paris Descartes JoVE 50894 Biology