Kevin Eggan

Publications

• A Multiplexed GRNA PiggyBac Transposon System Facilitates Efficient Induction of CRISPRi and CRISPRa in Human Pluripotent Stem Cells
  Scientific Reports. Jan, 2020  |   Pubmed ID: 31959800
• Publisher Correction: Exome Sequencing in Amyotrophic Lateral Sclerosis Implicates a Novel Gene, DNAJC7, Encoding a Heat-shock Protein
  Nature Neuroscience. Feb, 2020  |   Pubmed ID: 31857710
• Herpesviral Lytic Gene Functions Render the Viral Genome Susceptible to Novel Editing by CRISPR/Cas9
  ELife. 12, 2019  |   Pubmed ID: 31789594
• Exome Sequencing in Amyotrophic Lateral Sclerosis Implicates a Novel Gene, DNAJC7, Encoding a Heat-shock Protein
  Nature Neuroscience. 12, 2019  |   Pubmed ID: 31768050
• RNA-seq As a Tool for Evaluating Human Embryo Competence
  Genome Research. 10, 2019  |   Pubmed ID: 31548358
• Cancer-Related Mutations Identified in Primed and Naive Human Pluripotent Stem Cells
  Cell Stem Cell. Oct, 2019  |   Pubmed ID: 31543368
• A High-Content Screen Identifies TPP1 and Aurora B As Regulators of Axonal Mitochondrial Transport
  Cell Reports. Sep, 2019  |   Pubmed ID: 31533043
• Comparison of Three Congruent Patient-specific Cell Types for the Modelling of a Human Genetic Schwann-cell Disorder
  Nature Biomedical Engineering. 07, 2019  |   Pubmed ID: 30962586
• Dysregulated Protocadherin-pathway Activity As an Intrinsic Defect in Induced Pluripotent Stem Cell-derived Cortical Interneurons from Subjects with Schizophrenia
  Nature Neuroscience. 02, 2019  |   Pubmed ID: 30664768
• ALS-implicated Protein TDP-43 Sustains Levels of STMN2, a Mediator of Motor Neuron Growth and Repair
  Nature Neuroscience. 02, 2019  |   Pubmed ID: 30643292
• A Stem Cell-Based Screening Platform Identifies Compounds That Desensitize Motor Neurons to Endoplasmic Reticulum Stress
  Molecular Therapy : the Journal of the American Society of Gene Therapy. 01, 2019  |   Pubmed ID: 30446391
• Convergence of Independent DISC1 Mutations on Impaired Neurite Growth Via Decreased UNC5D Expression
  Translational Psychiatry. 11, 2018  |   Pubmed ID: 30410030
• Oligodendrocyte Differentiation of Induced Pluripotent Stem Cells Derived from Subjects with Schizophrenias Implicate Abnormalities in Development
  Translational Psychiatry. 10, 2018  |   Pubmed ID: 30352993
• Comparative Genomic Analysis of Embryonic, Lineage-converted and Stem Cell-derived Motor Neurons
  Development (Cambridge, England). 11, 2018  |   Pubmed ID: 30337375
• All-optical Synaptic Electrophysiology Probes Mechanism of Ketamine-induced Disinhibition
  Nature Methods. 10, 2018  |   Pubmed ID: 30275587
• Hippo Signaling in the Ovary and Polycystic Ovarian Syndrome
  Journal of Assisted Reproduction and Genetics. Oct, 2018  |   Pubmed ID: 30120633
• Dipeptide Repeat Proteins Activate a Heat Shock Response Found in C9ORF72-ALS/FTLD Patients
  Acta Neuropathologica Communications. 07, 2018  |   Pubmed ID: 29973287
• The C9orf72-interacting Protein Smcr8 is a Negative Regulator of Autoimmunity and Lysosomal Exocytosis
  Genes & Development. 07, 2018  |   Pubmed ID: 29950492
• TDP-43 Induces P53-mediated Cell Death of Cortical Progenitors and Immature Neurons
  Scientific Reports. 05, 2018  |   Pubmed ID: 29802307
• Combining NGN2 Programming with Developmental Patterning Generates Human Excitatory Neurons with NMDAR-Mediated Synaptic Transmission
  Cell Reports. 05, 2018  |   Pubmed ID: 29791859
• All-Optical Electrophysiology for High-Throughput Functional Characterization of a Human IPSC-Derived Motor Neuron Model of ALS
  Stem Cell Reports. 06, 2018  |   Pubmed ID: 29779896
• Publisher Correction: Whole Genome Sequencing in Psychiatric Disorders: the WGSPD Consortium
  Nature Neuroscience. Jul, 2018  |   Pubmed ID: 29549319
• Whole Genome Sequencing in Psychiatric Disorders: the WGSPD Consortium
  Nature Neuroscience. 12, 2017  |   Pubmed ID: 29184211
• Generation of a Motor Nerve Organoid with Human Stem Cell-Derived Neurons
  Stem Cell Reports. 11, 2017  |   Pubmed ID: 29107592
• A Scaled Framework for CRISPR Editing of Human Pluripotent Stem Cells to Study Psychiatric Disease
  Stem Cell Reports. 10, 2017  |   Pubmed ID: 29020615
• Reactive Astrocytes Promote ALS-like Degeneration and Intracellular Protein Aggregation in Human Motor Neurons by Disrupting Autophagy Through TGF-β1
  Stem Cell Reports. Aug, 2017  |   Pubmed ID: 28712846
• Assessing the Safety of Human Pluripotent Stem Cells and Their Derivatives for Clinical Applications
  Stem Cell Reports. Jul, 2017  |   Pubmed ID: 28700896
• Human Pluripotent Stem Cells Recurrently Acquire and Expand Dominant Negative P53 Mutations
  Nature. 05, 2017  |   Pubmed ID: 28445466
• Genetic Ablation of AXL Does Not Protect Human Neural Progenitor Cells and Cerebral Organoids from Zika Virus Infection
  Cell Stem Cell. Dec, 2016  |   Pubmed ID: 27912091
• Generation of a TLE3 Heterozygous Knockout Human Embryonic Stem Cell Line Using CRISPR-Cas9
  Stem Cell Research. Sep, 2016  |   Pubmed ID: 27879221
• Generation of a TLE1 Homozygous Knockout Human Embryonic Stem Cell Line Using CRISPR-Cas9
  Stem Cell Research. Sep, 2016  |   Pubmed ID: 27879218
• Two Familial ALS Proteins Function in Prevention/repair of Transcription-associated DNA Damage
  Proceedings of the National Academy of Sciences of the United States of America. Nov, 2016  |   Pubmed ID: 27849576
• Monitoring Peripheral Nerve Degeneration in ALS by Label-free Stimulated Raman Scattering Imaging
  Nature Communications. Oct, 2016  |   Pubmed ID: 27796305
• Comprehensive Protocols for CRISPR/Cas9-based Gene Editing in Human Pluripotent Stem Cells
  Current Protocols in Stem Cell Biology. Aug, 2016  |   Pubmed ID: 27532820
• Loss-of-function Mutations in the C9ORF72 Mouse Ortholog Cause Fatal Autoimmune Disease
  Science Translational Medicine. Jul, 2016  |   Pubmed ID: 27412785
• CAT7 and Cat7l Long Non-coding RNAs Tune Polycomb Repressive Complex 1 Function During Human and Zebrafish Development
  The Journal of Biological Chemistry. Sep, 2016  |   Pubmed ID: 27405765
• Modeling ALS with Motor Neurons Derived from Human Induced Pluripotent Stem Cells
  Nature Neuroscience. Apr, 2016  |   Pubmed ID: 27021939
• SLC52A3, A Brown-Vialetto-van Laere Syndrome Candidate Gene is Essential for Mouse Development, but Dispensable for Motor Neuron Differentiation
  Human Molecular Genetics. May, 2016  |   Pubmed ID: 26976849
• A Perspective on Stem Cell Modeling of Amyotrophic Lateral Sclerosis
  Cell Cycle (Georgetown, Tex.). 2015  |   Pubmed ID: 26505672
• Automated, High-throughput Derivation, Characterization and Differentiation of Induced Pluripotent Stem Cells
  Nature Methods. Sep, 2015  |   Pubmed ID: 26237226
• From Dish to Bedside: Lessons Learned While Translating Findings from a Stem Cell Model of Disease to a Clinical Trial
  Cell Stem Cell. Jul, 2015  |   Pubmed ID: 26140603
• Efficient CRISPR-Cas9-mediated Generation of Knockin Human Pluripotent Stem Cells Lacking Undesired Mutations at the Targeted Locus
  Cell Reports. May, 2015  |   Pubmed ID: 25937281
• Focus on Induced Pluripotency and Cellular Reprogramming
  The EMBO Journal. Jun, 2015  |   Pubmed ID: 25916828
• Generation of Neuropeptidergic Hypothalamic Neurons from Human Pluripotent Stem Cells
  Development (Cambridge, England). Feb, 2015  |   Pubmed ID: 25670790
• ALS-causative Mutations in FUS/TLS Confer Gain and Loss of Function by Altered Association with SMN and U1-snRNP
  Nature Communications. 2015  |   Pubmed ID: 25625564
• Motoneurons Derived from Induced Pluripotent Stem Cells Develop Mature Phenotypes Typical of Endogenous Spinal Motoneurons
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jan, 2015  |   Pubmed ID: 25609642
• Modeling Pain in Vitro Using Nociceptor Neurons Reprogrammed from Fibroblasts
  Nature Neuroscience. Jan, 2015  |   Pubmed ID: 25420066
• IPSC-derived Dopamine Neurons Reveal Differences Between Monozygotic Twins Discordant for Parkinson's Disease
  Cell Reports. Nov, 2014  |   Pubmed ID: 25456120
• Genetic Variation in Human DNA Replication Timing
  Cell. Nov, 2014  |   Pubmed ID: 25416942
• The Role of Maternal-specific H3K9me3 Modification in Establishing Imprinted X-chromosome Inactivation and Embryogenesis in Mice
  Nature Communications. 2014  |   Pubmed ID: 25394724
• Genetic Validation of a Therapeutic Target in a Mouse Model of ALS
  Science Translational Medicine. Aug, 2014  |   Pubmed ID: 25100738
• DNA Methylation Dynamics of the Human Preimplantation Embryo
  Nature. Jul, 2014  |   Pubmed ID: 25079558
• FUS is Sequestered in Nuclear Aggregates in ALS Patient Fibroblasts
  Molecular Biology of the Cell. Sep, 2014  |   Pubmed ID: 25009283
• Notch Inhibition Allows Oncogene-independent Generation of IPS Cells
  Nature Chemical Biology. Aug, 2014  |   Pubmed ID: 24952596
• Ketamine Exposure in Early Development Impairs Specification of the Primary Germ Cell Layers
  Neurotoxicology and Teratology. May-Jun, 2014  |   Pubmed ID: 24746641
• Pathways Disrupted in Human ALS Motor Neurons Identified Through Genetic Correction of Mutant SOD1
  Cell Stem Cell. Jun, 2014  |   Pubmed ID: 24704492
• Intrinsic Membrane Hyperexcitability of Amyotrophic Lateral Sclerosis Patient-derived Motor Neurons
  Cell Reports. Apr, 2014  |   Pubmed ID: 24703839
• Gene Profiling of Human Induced Pluripotent Stem Cell-derived Astrocyte Progenitors Following Spinal Cord Engraftment
  Stem Cells Translational Medicine. May, 2014  |   Pubmed ID: 24604284
• Nanog-independent Reprogramming to IPSCs with Canonical Factors
  Stem Cell Reports. Feb, 2014  |   Pubmed ID: 24527385
• Axonal Transport of TDP-43 MRNA Granules is Impaired by ALS-causing Mutations
  Neuron. Feb, 2014  |   Pubmed ID: 24507191
• How to Make Spinal Motor Neurons
  Development (Cambridge, England). Feb, 2014  |   Pubmed ID: 24449832
• Picking the Lock on Pluripotency
  The New England Journal of Medicine. Nov, 2013  |   Pubmed ID: 24283230
• The Mouse C9ORF72 Ortholog is Enriched in Neurons Known to Degenerate in ALS and FTD
  Nature Neuroscience. Dec, 2013  |   Pubmed ID: 24185425
• Derivation of Induced Pluripotent Stem Cells from the Baboon: a Nonhuman Primate Model for Preclinical Testing of Stem Cell Therapies
  Cellular Reprogramming. Dec, 2013  |   Pubmed ID: 24182315
• Opportunities and Challenges of Pluripotent Stem Cell Neurodegenerative Disease Models
  Nature Neuroscience. Jul, 2013  |   Pubmed ID: 23799470
• Modeling Human Disease with Pluripotent Stem Cells: from Genome Association to Function
  Cell Stem Cell. Jun, 2013  |   Pubmed ID: 23746975
• Directed Differentiation and Functional Maturation of Cortical Interneurons from Human Embryonic Stem Cells
  Cell Stem Cell. May, 2013  |   Pubmed ID: 23642365
• CLP1 Links TRNA Metabolism to Progressive Motor-neuron Loss
  Nature. Mar, 2013  |   Pubmed ID: 23474986
• Analysis of Human Embryos from Zygote to Blastocyst Reveals Distinct Gene Expression Patterns Relative to the Mouse
  Developmental Biology. Mar, 2013  |   Pubmed ID: 23261930
• Developmental Bias in Cleavage-stage Mouse Blastomeres
  Current Biology : CB. Jan, 2013  |   Pubmed ID: 23177476
• SnapShot: Directed Differentiation of Pluripotent Stem Cells
  Cell. May, 2012  |   Pubmed ID: 22632979
• Erosion of Dosage Compensation Impacts Human IPSC Disease Modeling
  Cell Stem Cell. May, 2012  |   Pubmed ID: 22560080
• Impracticality of Egg Donor Recruitment in the Absence of Compensation
  Cell Stem Cell. Oct, 2011  |   Pubmed ID: 21982228
• Reprogramming Within Hours Following Nuclear Transfer into Mouse but Not Human Zygotes
  Nature Communications. 2011  |   Pubmed ID: 21971503
• Conversion of Mouse and Human Fibroblasts into Functional Spinal Motor Neurons
  Cell Stem Cell. Sep, 2011  |   Pubmed ID: 21852222
• Constructing and Deconstructing Stem Cell Models of Neurological Disease
  Neuron. May, 2011  |   Pubmed ID: 21609821
• Somatic Coding Mutations in Human Induced Pluripotent Stem Cells
  Nature. Mar, 2011  |   Pubmed ID: 21368825
• Reference Maps of Human ES and IPS Cell Variation Enable High-throughput Characterization of Pluripotent Cell Lines
  Cell. Feb, 2011  |   Pubmed ID: 21295703
• A Functionally Characterized Test Set of Human Induced Pluripotent Stem Cells
  Nature Biotechnology. Mar, 2011  |   Pubmed ID: 21293464
• Shushing Down the Epigenetic Landscape Towards Stem Cell Differentiation
  Development (Cambridge, England). Aug, 2010  |   Pubmed ID: 20554719
• Recipient Cell Nuclear Factors Are Required for Reprogramming by Nuclear Transfer
  Development (Cambridge, England). Jun, 2010  |   Pubmed ID: 20463036
• Sox17 Promotes Differentiation in Mouse Embryonic Stem Cells by Directly Regulating Extraembryonic Gene Expression and Indirectly Antagonizing Self-renewal
  Genes & Development. Feb, 2010  |   Pubmed ID: 20123909
• Progress Toward the Clinical Application of Patient-specific Pluripotent Stem Cells
  The Journal of Clinical Investigation. Jan, 2010  |   Pubmed ID: 20051636
• A Small-molecule Inhibitor of Tgf-Beta Signaling Replaces Sox2 in Reprogramming by Inducing Nanog
  Cell Stem Cell. Nov, 2009  |   Pubmed ID: 19818703
• Reprogramming After Chromosome Transfer into Mouse Blastomeres
  Current Biology : CB. Aug, 2009  |   Pubmed ID: 19682906
• Digital RNA Allelotyping Reveals Tissue-specific and Allele-specific Gene Expression in Human
  Nature Methods. Aug, 2009  |   Pubmed ID: 19620972
• Targeted Bisulfite Sequencing Reveals Changes in DNA Methylation Associated with Nuclear Reprogramming
  Nature Biotechnology. Apr, 2009  |   Pubmed ID: 19330000
• Optimal Timing of Inner Cell Mass Isolation Increases the Efficiency of Human Embryonic Stem Cell Derivation and Allows Generation of Sibling Cell Lines
  Cell Stem Cell. Feb, 2009  |   Pubmed ID: 19200798
• Human Embryonic Stem Cell-derived Motor Neurons Are Sensitive to the Toxic Effect of Glial Cells Carrying an ALS-causing Mutation
  Cell Stem Cell. Dec, 2008  |   Pubmed ID: 19041780
• Using Stem Cells and Reprogramming to Understand Disease
  Regenerative Medicine. Nov, 2008  |   Pubmed ID: 18947303
• Induced Pluripotent Stem Cells Generated from Patients with ALS Can Be Differentiated into Motor Neurons
  Science (New York, N.Y.). Aug, 2008  |   Pubmed ID: 18669821
• Mediators of Reprogramming: Transcription Factors and Transitions Through Mitosis
  Nature Reviews. Molecular Cell Biology. Jul, 2008  |   Pubmed ID: 18568039
• Short-circuiting Epiblast Development
  Cell Stem Cell. Aug, 2007  |   Pubmed ID: 18371343
• Developmental Reprogramming After Chromosome Transfer into Mitotic Mouse Zygotes
  Nature. Jun, 2007  |   Pubmed ID: 17554301
• Non-cell Autonomous Effect of Glia on Motor Neurons in an Embryonic Stem Cell-based ALS Model
  Nature Neuroscience. May, 2007  |   Pubmed ID: 17435754
• Dolly's Legacy: Human Nuclear Transplantation and Better Medicines for Our Children
  Cloning and Stem Cells. 2007  |   Pubmed ID: 17386009
• The Potential of Cell Fusion for Human Therapy
  Stem Cell Reviews. 2006  |   Pubmed ID: 17848721
• A Transcriptional Logic for Nuclear Reprogramming
  Cell. Aug, 2006  |   Pubmed ID: 16923385
• Ovulated Oocytes in Adult Mice Derive from Non-circulating Germ Cells
  Nature. Jun, 2006  |   Pubmed ID: 16799565
• Nuclear Reprogramming of Somatic Cells After Fusion with Human Embryonic Stem Cells
  Science (New York, N.Y.). Aug, 2005  |   Pubmed ID: 16123299
• Nuclear Cloning, Epigenetic Reprogramming and Cellular Differentiation
  Novartis Foundation Symposium. 2005  |   Pubmed ID: 16050253
• Mice Cloned from Olfactory Sensory Neurons
  Nature. Mar, 2004  |   Pubmed ID: 14990966
• Derivation of Embryonic Germ Cells and Male Gametes from Embryonic Stem Cells
  Nature. Jan, 2004  |   Pubmed ID: 14668819
• Micromanipulating Dosage Compensation: Understanding X-chromosome Inactivation Through Nuclear Transplantation
  Seminars in Cell & Developmental Biology. Dec, 2003  |   Pubmed ID: 15015742
• Differentiation of F1 Embryonic Stem Cells into Viable Male and Female Mice by Tetraploid Embryo Complementation
  Methods in Enzymology. 2003  |   Pubmed ID: 14696335
• Incomplete Reactivation of Oct4-related Genes in Mouse Embryos Cloned from Somatic Nuclei
  Development (Cambridge, England). Apr, 2003  |   Pubmed ID: 12620990
• Nuclear Cloning, Stem Cells, and Genomic Reprogramming
  Cloning and Stem Cells. 2002  |   Pubmed ID: 12630413
• Abnormal Gene Expression in Cloned Mice Derived from Embryonic Stem Cell and Cumulus Cell Nuclei
  Proceedings of the National Academy of Sciences of the United States of America. Oct, 2002  |   Pubmed ID: 12235366
• Male and Female Mice Derived from the Same Embryonic Stem Cell Clone by Tetraploid Embryo Complementation
  Nature Biotechnology. May, 2002  |   Pubmed ID: 11981557
• Dnmt1 Overexpression Causes Genomic Hypermethylation, Loss of Imprinting, and Embryonic Lethality
  Molecular and Cellular Biology. Apr, 2002  |   Pubmed ID: 11884600
• Flp Recombinase Regulated LacZ Expression at the ROSA26 Locus
  Genesis (New York, N.Y. : 2000). Feb, 2002  |   Pubmed ID: 11857816