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In JoVE (1)
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Articles by Manoel Neves Jr. in JoVE
JoVE Clinical and Translational Medicine
Oclusão Vascular Formação para a Inclusão Miosite Corpo: uma nova abordagem terapêutica
1School of Physical Education and Sport, University of São Paulo, 2Division of Rheumatology, School of Medicine, University of São Paulo
O presente artigo apresenta os detalhes relativos à aplicação de treinamento de resistência associado à oclusão vascular em pacientes IBM.
Other articles by Manoel Neves Jr. on PubMed
Resistance Training with Vascular Occlusion in Inclusion Body Myositis: a Case Study
Inclusion body myositis (IBM) is a rare idiopathic inflammatory myopathy that produces remarkable muscle weakness. Resistance training with vascular occlusion has been shown to improve muscle strength and cross-sectional area in other muscle wasting conditions.
Creatine in Type 2 Diabetes: a Randomized, Double-blind, Placebo-controlled Trial
Creatine supplementation improves glucose tolerance in healthy subjects.
Beneficial Effect of Creatine Supplementation in Knee Osteoarthritis
The aim of this study was to investigate the efficacy of creatine (CR) supplementation combined with strengthening exercises in knee osteoarthritis (OA).
Effect of Creatine Supplementation on Measured Glomerular Filtration Rate in Postmenopausal Women
We aimed to investigate whether creatine supplementation affects the measured glomerular filtration rate in postmenopausal women (age, 58 ± 3 years). Subjects were randomly assigned to receive either creatine (20 g·day(-1) for 1 week and 5 g·day(-1) thereafter) or a placebo. Kidney function was assessed at baseline and after 12 weeks. [(51)Cr]EDTA clearance remained unchanged (CR-PRE: 86.16 ± 14.36 mL·min(-1) per 1.73 m(2), POST: 87.25 ± 17.60 mL·min(-1) per 1.73 m(2); PL-PRE: 85.15 ± 8.54 mL·min(-1) per 1.73 m(2), POST: 87.18 ± 9.64 mL·min(-1) per 1.73 m(2); p = 0.81). Thus, we concluded that creatine supplementation does not affect glomerular filtration rate in postmenopausal women.
Strength Training with Blood Flow Restriction Diminishes Myostatin Gene Expression
PURPOSE:: The aim of the study was to determine whether the similar muscle strength and hypertrophy responses observed after either low-intensity resistance exercise associated with moderate blood-flow restriction or high-intensity resistance exercise are associated with similar changes in mRNA expression of selected genes involved in the myostatin (MSTN) signaling. METHODS:: Twenty-nine physically active male subjects were divided into three groups: low-intensity (20% 1-RM) resistance training: LI (n = 10); low-intensity (20% 1-RM) resistance training associated with moderate blood-flow restriction: LIR (n = 10); and high-intensity (80% 1-RM) resistance training: HI (n = 9). All of the groups underwent an 8-week training program. Maximal dynamic knee-extension strength (1-RM), quadriceps cross-sectional area (CSA), MSTN, follistatin-like related genes (FLST, FLST-3), activin IIb, growth and differentiation factor- associated serum protein 1 (GASP-1), and MAD-related protein (SMAD-7) mRNA gene expression were assessed pre- and post-training. RESULTS:: Knee extension 1-RM significantly increased in all groups (LI: 20.7%, LIR: 40.1%, and HI: 36.2%). CSA increased in both LIR and HI groups (6.3 and 6.1%, respectively). MSTN mRNA expression decreased in the LIR and HI groups (45% and 41%, respectively). There were no significant changes in activin IIb (p>0.05). FLST and FLST-3 mRNA expression increased in all groups from pre- to post-test (p<0.001). FLST-3 expression was significantly greater in the HI when compared to LIR and LI groups at post-test (p=0.024 and p=0.018, respectively). GASP-1 and SMAD-7 gene expression significantly increased in both LIR and HI groups. CONCLUSION:: We concluded that LIR was able to induce similar gains in 1-RM and quadriceps CSA than those observed after traditional HI. These responses may be related to the concomitant decrease in MSTN and increase in FLST-isoforms, GASP-1 and SMAD-7 mRNA gene expression.
