Mark A. Atkinson Department of Pathology, Immunology, and Laboratory Medicine University of Florida Biography Publications Institution JoVE Articles Mark A. Atkinson has not added a biography. If you are Mark A. Atkinson and would like to personalize this page please email our Author Liaison for assistance. Publications Distinguishing the Real from the Hyperglycaemia: Does COVID-19 Induce Diabetes? The Lancet. Diabetes & Endocrinology. Apr, 2021 | Pubmed ID: 33838106 Islet Sympathetic Innervation and Islet Neuropathology in Patients with Type 1 Diabetes Scientific Reports. Mar, 2021 | Pubmed ID: 33753784 Insulin Receptor-Expressing T Cells Appear in Individuals at Risk for Type 1 Diabetes and Can Move into the Pancreas in C57BL/6 Transgenic Mice Journal of Immunology (Baltimore, Md. : 1950). Apr, 2021 | Pubmed ID: 33658296 Low-dose ATG/GCSF in Established Type 1 Diabetes: A Five-Year Follow-up Report Diabetes. Feb, 2021 | Pubmed ID: 33632742 TCR/BCR Dual-expressing Cells and Their Associated Public BCR Clonotype Are Not Enriched in Type 1 Diabetes Cell. Feb, 2021 | Pubmed ID: 33545036 Interleukin-27 is Essential for Type 1 Diabetes Development and Sjögren Syndrome-like Inflammation Cell Reports. Feb, 2021 | Pubmed ID: 33535031 Index60 As an Additional Diagnostic Criterion for Type 1 Diabetes Diabetologia. Apr, 2021 | Pubmed ID: 33496819 Integrative Analyses of TEDDY Omics Data Reveal Lipid Metabolism Abnormalities, Increased Intracellular ROS and Heightened Inflammation Prior to Autoimmunity for Type 1 Diabetes Genome Biology. Jan, 2021 | Pubmed ID: 33478573 Modulation of Leukocytes of the Innate Arm of the Immune System As a Potential Approach to Prevent the Onset and Progression of Type 1 Diabetes Diabetes. Feb, 2021 | Pubmed ID: 33472941 Exocrine Pancreatic Enzymes Are a Serological Biomarker for Type 1 Diabetes Staging and Pancreas Size Diabetes. Apr, 2021 | Pubmed ID: 33441381 Genetic Composition and Autoantibody Titers Model the Probability of Detecting C-Peptide Following Type 1 Diabetes Diagnosis Diabetes. Apr, 2021 | Pubmed ID: 33419759 Image-Based Machine Learning Algorithms for Disease Characterization in the Human Type 1 Diabetes Pancreas The American Journal of Pathology. 03, 2021 | Pubmed ID: 33307036 Exocrine Pancreas Dysfunction in Type 1 Diabetes Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists. Dec, 2020 | Pubmed ID: 33471743 Evaluation for Type 1 Diabetes Associated Autoantibodies in Diabetic and Non-diabetic Australian Terriers and Samoyeds Canine Medicine and Genetics. Aug, 2020 | Pubmed ID: 33323126 Pancreatlas: Applying an Adaptable Framework to Map the Human Pancreas in Health and Disease Patterns (New York, N.Y.). Nov, 2020 | Pubmed ID: 33294866 Expression of SARS-CoV-2 Entry Factors in the Pancreas of Normal Organ Donors and Individuals with COVID-19 Cell Metabolism. 12, 2020 | Pubmed ID: 33207244 Immunomodulatory Dual-Sized Microparticle System Conditions Human Antigen Presenting Cells Into a Tolerogenic Phenotype and Inhibits Type 1 Diabetes-Specific Autoreactive T Cell Responses Frontiers in Immunology. 2020 | Pubmed ID: 33193362 CD226 Deletion Reduces Type 1 Diabetes in the NOD Mouse by Impairing Thymocyte Development and Peripheral T Cell Activation Frontiers in Immunology. 2020 | Pubmed ID: 33013915 Organisation of the Human Pancreas in Health and in Diabetes Diabetologia. 10, 2020 | Pubmed ID: 32894306 Comparing Beta Cell Preservation Across Clinical Trials in Recent-Onset Type 1 Diabetes Diabetes Technology & Therapeutics. 12, 2020 | Pubmed ID: 32833543 Removing Formaldehyde-Induced Peptidyl Crosslinks Enables Mass Spectrometry Imaging of Peptide Hormone Distributions from Formalin-Fixed Paraffin-Embedded Tissues Angewandte Chemie (International Ed. in English). 12, 2020 | Pubmed ID: 32762062 Intestinal Delivery of Proinsulin and IL-10 Via Combined With Low-Dose Anti-CD3 Restores Tolerance Outside the Window of Acute Type 1 Diabetes Diagnosis Frontiers in Immunology. 2020 | Pubmed ID: 32582188 Multiplexing DNA Methylation Markers to Detect Circulating Cell-free DNA Derived from Human Pancreatic β Cells JCI Insight. 07, 2020 | Pubmed ID: 32573495 Large-scale Electron Microscopy Database for Human Type 1 Diabetes Nature Communications. 05, 2020 | Pubmed ID: 32424134 Pancreas Tissue Slices from Organ Donors Enable in Situ Analysis of Type 1 Diabetes Pathogenesis JCI Insight. 04, 2020 | Pubmed ID: 32324170 Commercially Available Insulin Products Demonstrate Stability Throughout the Cold Supply Chain Across the U.S Diabetes Care. 06, 2020 | Pubmed ID: 32273273 Obesity Treatment Among Adolescents: A Review of Current Evidence and Future Directions JAMA Pediatrics. 06, 2020 | Pubmed ID: 32202626 Innate Inflammation Drives NK Cell Activation to Impair Treg Activity Journal of Autoimmunity. 03, 2020 | Pubmed ID: 32035746 Early and Late C-peptide Responses During Oral Glucose Tolerance Testing Are Oppositely Predictive of Type 1 Diabetes in Autoantibody-positive Individuals Diabetes, Obesity & Metabolism. 06, 2020 | Pubmed ID: 32003110 Single Islet Autoantibody at Diagnosis of Clinical Type 1 Diabetes is Associated With Older Age and Insulin Resistance The Journal of Clinical Endocrinology and Metabolism. 05, 2020 | Pubmed ID: 31867614 Insulin-Like Growth Factor Dysregulation Both Preceding and Following Type 1 Diabetes Diagnosis Diabetes. 03, 2020 | Pubmed ID: 31826866 The Risk of Progression to Type 1 Diabetes is Highly Variable in Individuals with Multiple Autoantibodies Following Screening Diabetologia. 03, 2020 | Pubmed ID: 31768570 Introducing the Endotype Concept to Address the Challenge of Disease Heterogeneity in Type 1 Diabetes Diabetes Care. 01, 2020 | Pubmed ID: 31753960 Temporal Analysis of Amylase Expression in Control, Autoantibody-Positive, and Type 1 Diabetes Pancreatic Tissues Diabetes. 01, 2020 | Pubmed ID: 31597639 Interleukin-27 Is Essential for Type 1 Diabetes Development and Sjögren Syndrome-like Inflammation Cell Reports. 12, 2019 | Pubmed ID: 31801074 Who Is Enrolling? The Path to Monitoring in Type 1 Diabetes TrialNet's Pathway to Prevention Diabetes Care. 12, 2019 | Pubmed ID: 31558546 Regulated HAAT Expression from a Novel RAAV Vector and Its Application in the Prevention of Type 1 Diabetes Journal of Clinical Medicine. Aug, 2019 | Pubmed ID: 31466263 Genetic Risk for Autoimmunity is Associated with Distinct Changes in the Human Gut Microbiome Nature Communications. 08, 2019 | Pubmed ID: 31399563 The Influence of Type 2 Diabetes-Associated Factors on Type 1 Diabetes Diabetes Care. 08, 2019 | Pubmed ID: 31167894 Pleiotropic Roles of the Insulin-like Growth Factor Axis in Type 1 Diabetes Current Opinion in Endocrinology, Diabetes, and Obesity. 08, 2019 | Pubmed ID: 31145130 NIH Initiative to Improve Understanding of the Pancreas, Islet, and Autoimmunity in Type 1 Diabetes: The Human Pancreas Analysis Program (HPAP) Diabetes. 07, 2019 | Pubmed ID: 31127054 Dual-Sized Microparticle System for Generating Suppressive Dendritic Cells Prevents and Reverses Type 1 Diabetes in the Nonobese Diabetic Mouse Model ACS Biomaterials Science & Engineering. May, 2019 | Pubmed ID: 31119191 Islet Amyloidosis in a Child with Type 1 Diabetes Islets. 2019 | Pubmed ID: 31084520 Large Enteroviral Vaccination Studies to Prevent Type 1 Diabetes Should Be Well Founded and Rely on Scientific Evidence. Reply to Skog O, Klingel K, Roivainen M Et Al [letter] Diabetologia. 06, 2019 | Pubmed ID: 31016358 Low-Dose Anti-Thymocyte Globulin Preserves C-Peptide, Reduces HbA, and Increases Regulatory to Conventional T-Cell Ratios in New-Onset Type 1 Diabetes: Two-Year Clinical Trial Data Diabetes. 06, 2019 | Pubmed ID: 30967424 Increased Risk for T Cell Autoreactivity to ß-cell Antigens in the Mice Expressing the A Obesity-associated Gene Scientific Reports. 03, 2019 | Pubmed ID: 30862859 Boosting to Amplify Signal with Isobaric Labeling (BASIL) Strategy for Comprehensive Quantitative Phosphoproteomic Characterization of Small Populations of Cells Analytical Chemistry. May, 2019 | Pubmed ID: 30843680 Multiplexed In Situ Imaging Mass Cytometry Analysis of the Human Endocrine Pancreas and Immune System in Type 1 Diabetes Cell Metabolism. 03, 2019 | Pubmed ID: 30713110 A Map of Human Type 1 Diabetes Progression by Imaging Mass Cytometry Cell Metabolism. 03, 2019 | Pubmed ID: 30713109 Rationale for Enteroviral Vaccination and Antiviral Therapies in Human Type 1 Diabetes Diabetologia. 05, 2019 | Pubmed ID: 30675626 Type 1 Diabetes Risk in African-Ancestry Participants and Utility of an Ancestry-Specific Genetic Risk Score Diabetes Care. 03, 2019 | Pubmed ID: 30659077 Relative Pancreas Volume Is Reduced in First-Degree Relatives of Patients With Type 1 Diabetes Diabetes Care. 02, 2019 | Pubmed ID: 30552130 The Challenge of Modulating β-cell Autoimmunity in Type 1 Diabetes The Lancet. Diabetes & Endocrinology. 01, 2019 | Pubmed ID: 30528099 Islet Microvasculature Alterations With Loss of Beta-cells in Patients With Type 1 Diabetes The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 01, 2019 | Pubmed ID: 29771178 Characterization of Non-hormone Expressing Endocrine Cells in Fetal and Infant Human Pancreas Frontiers in Endocrinology. 2018 | Pubmed ID: 30687234 Transcription Factor 7-Like 2 () Gene Polymorphism and Progression From Single to Multiple Autoantibody Positivity in Individuals at Risk for Type 1 Diabetes Diabetes Care. 12, 2018 | Pubmed ID: 30275285 Nanowell-mediated Two-dimensional Liquid Chromatography Enables Deep Proteome Profiling of <1000 Mammalian Cells Chemical Science. Sep, 2018 | Pubmed ID: 30210768 Islet-Derived EATP Fuels Autoreactive CD8 T Cells and Facilitates the Onset of Type 1 Diabetes Diabetes. 10, 2018 | Pubmed ID: 30065030 Low-Dose Anti-Thymocyte Globulin (ATG) Preserves β-Cell Function and Improves HbA in New-Onset Type 1 Diabetes Diabetes Care. Sep, 2018 | Pubmed ID: 30012675 Protective Role of Myeloid Cells Expressing a G-CSF Receptor Polymorphism in an Induced Model of Lupus Frontiers in Immunology. 2018 | Pubmed ID: 29868014 Strength in Numbers: Opportunities for Enhancing the Development of Effective Treatments for Type 1 Diabetes-The TrialNet Experience Diabetes. 07, 2018 | Pubmed ID: 29769238 Type 1 Diabetes TrialNet: A Multifaceted Approach to Bringing Disease-Modifying Therapy to Clinical Use in Type 1 Diabetes Diabetes Care. 04, 2018 | Pubmed ID: 29559451 Methyldopa Blocks MHC Class II Binding to Disease-specific Antigens in Autoimmune Diabetes The Journal of Clinical Investigation. 05, 2018 | Pubmed ID: 29438107 Loss of B-Cell Anergy in Type 1 Diabetes Is Associated With High-Risk HLA and Non-HLA Disease Susceptibility Alleles Diabetes. 04, 2018 | Pubmed ID: 29343548 Hospital Time Prior to Death and Pancreas Histopathology: Implications for Future Studies Diabetologia. 04, 2018 | Pubmed ID: 29128936 Pancreatic Histopathology of Human Monogenic Diabetes Due to Causal Variants in KCNJ11, HNF1A, GATA6, and LMNA The Journal of Clinical Endocrinology and Metabolism. Jan, 2018 | Pubmed ID: 28938416 Transient BAFF Blockade Inhibits Type 1 Diabetes Development in Nonobese Diabetic Mice by Enriching Immunoregulatory B Lymphocytes Sensitive to Deletion by Anti-CD20 Cotherapy Journal of Immunology (Baltimore, Md. : 1950). 12, 2017 | Pubmed ID: 29055002 Association Between Early-Life Antibiotic Use and the Risk of Islet or Celiac Disease Autoimmunity JAMA Pediatrics. 12, 2017 | Pubmed ID: 29052687 Disease-specific Biases in Alternative Splicing and Tissue-specific Dysregulation Revealed by Multitissue Profiling of Lymphocyte Gene Expression in Type 1 Diabetes Genome Research. 11, 2017 | Pubmed ID: 29025893 T Cells Display Mitochondria Hyperpolarization in Human Type 1 Diabetes Scientific Reports. 09, 2017 | Pubmed ID: 28883439 Type 1 Interferons Potentiate Human CD8 T-Cell Cytotoxicity Through a STAT4- and Granzyme B-Dependent Pathway Diabetes. 12, 2017 | Pubmed ID: 28877912 Proteoliposome-based Full-length ZnT8 Self-antigen for Type 1 Diabetes Diagnosis on a Plasmonic Platform Proceedings of the National Academy of Sciences of the United States of America. 09, 2017 | Pubmed ID: 28874568 Dysglycemia and Index60 As Prediagnostic End Points for Type 1 Diabetes Prevention Trials Diabetes Care. 11, 2017 | Pubmed ID: 28860125 Untargeted Metabolomic Analysis in Naturally Occurring Canine Diabetes Mellitus Identifies Similarities to Human Type 1 Diabetes Scientific Reports. 08, 2017 | Pubmed ID: 28842637 Impact of Blood Collection and Processing on Peripheral Blood Gene Expression Profiling in Type 1 Diabetes BMC Genomics. Aug, 2017 | Pubmed ID: 28821222 High Illicit Drug Abuse and Suicide in Organ Donors With Type 1 Diabetes Diabetes Care. Sep, 2017 | Pubmed ID: 28679687 N6.2 Modulates the Host Immune Responses: A Double-Blind, Randomized Trial in Healthy Adults Frontiers in Immunology. 2017 | Pubmed ID: 28659913 Comparative Pathogenesis of Autoimmune Diabetes in Humans, NOD Mice, and Canines: Has a Valuable Animal Model of Type 1 Diabetes Been Overlooked? Diabetes. 06, 2017 | Pubmed ID: 28533295 Mary Tyler Moore (1936-2017): Diabetes Educator and Advocate Diabetes Care. 06, 2017 | Pubmed ID: 28533256 Genetic and Small Molecule Disruption of the AID/RAD51 Axis Similarly Protects Nonobese Diabetic Mice from Type 1 Diabetes Through Expansion of Regulatory B Lymphocytes Journal of Immunology (Baltimore, Md. : 1950). 06, 2017 | Pubmed ID: 28461573 Expansion of Human Tregs from Cryopreserved Umbilical Cord Blood for GMP-Compliant Autologous Adoptive Cell Transfer Therapy Molecular Therapy. Methods & Clinical Development. Mar, 2017 | Pubmed ID: 28345003 Plant-based Vaccines for Oral Delivery of Type 1 Diabetes-related Autoantigens: Evaluating Oral Tolerance Mechanisms and Disease Prevention in NOD Mice Scientific Reports. 02, 2017 | Pubmed ID: 28205558 Serum Trypsinogen Levels in Type 1 Diabetes Diabetes Care. 04, 2017 | Pubmed ID: 28115475 Re-addressing the 2013 Consensus Guidelines for the Diagnosis of Insulitis in Human Type 1 Diabetes: is Change Necessary? Diabetologia. Apr, 2017 | Pubmed ID: 28070616 Factors That Influence the Quality of RNA From the Pancreas of Organ Donors Pancreas. Feb, 2017 | Pubmed ID: 27984510 Rebranding Asymptomatic Type 1 Diabetes: the Case for Autoimmune Beta Cell Disorder As a Pathological and Diagnostic Entity Diabetologia. 01, 2017 | Pubmed ID: 27785529 Type 1 Diabetes Prevention: A Goal Dependent on Accepting a Diagnosis of an Asymptomatic Disease Diabetes. 11, 2016 | Pubmed ID: 27959859 Tissue Distribution and Clonal Diversity of the T and B Cell Repertoire in Type 1 Diabetes JCI Insight. Dec, 2016 | Pubmed ID: 27942583 Islet-derived CD4 T-cells Targeting Proinsulin in Human Autoimmune Diabetes Diabetes. Dec, 2016 | Pubmed ID: 27920090 Analysis of Self-antigen Specificity of Islet-infiltrating T Cells from Human Donors with Type 1 Diabetes Nature Medicine. Dec, 2016 | Pubmed ID: 27798614 Autoimmune Manifestations in Aged Mice Arise from Early-life Immune Dysregulation Science Translational Medicine. 10, 2016 | Pubmed ID: 27798262 Antithymocyte Globulin Plus G-CSF Combination Therapy Leads to Sustained Immunomodulatory and Metabolic Effects in a Subset of Responders With Established Type 1 Diabetes Diabetes. Dec, 2016 | Pubmed ID: 27669730 Islet Cell Hyperexpression of HLA Class I Antigens: a Defining Feature in Type 1 Diabetes Diabetologia. 11, 2016 | Pubmed ID: 27506584 Aberrant Menin Expression is an Early Event in Pancreatic Neuroendocrine Tumorigenesis Human Pathology. 10, 2016 | Pubmed ID: 27342911 Presumptive Type 1 Diabetes With Comorbidities and Rapid Progression Despite Numerous Insulin-Positive Islets Diabetes Care. 07, 2016 | Pubmed ID: 27330131 Sulfatide Preserves Insulin Crystals Not by Being Integrated in the Lattice but by Stabilizing Their Surface Journal of Diabetes Research. 2016 | Pubmed ID: 26981544 Type 1 Diabetes Cadaveric Human Pancreata Exhibit a Unique Exocrine Tissue Proteomic Profile Proteomics. 05, 2016 | Pubmed ID: 26935967 Pancreatic Duct Hyperplasia/dysplasia in Type 1 Diabetes and Pancreatic Weight in Individuals with and Without Diabetes. Reply to Kobayashi T, Aida K, Fukui T Et Al [letter] and Saisho Y [letter] Diabetologia. Apr, 2016 | Pubmed ID: 26861059 A Preclinical Consortium Approach for Assessing the Efficacy of Combined Anti-CD3 Plus IL-1 Blockade in Reversing New-Onset Autoimmune Diabetes in NOD Mice Diabetes. 05, 2016 | Pubmed ID: 26718498 Insulitis and β-Cell Mass in the Natural History of Type 1 Diabetes Diabetes. Mar, 2016 | Pubmed ID: 26581594 The Influence of Type 1 Diabetes on Pancreatic Weight Diabetologia. Jan, 2016 | Pubmed ID: 26358584 Immune Depletion in Combination with Allogeneic Islets Permanently Restores Tolerance to Self-Antigens in Diabetic NOD Mice PloS One. 2015 | Pubmed ID: 26580221 Staging Presymptomatic Type 1 Diabetes: a Scientific Statement of JDRF, the Endocrine Society, and the American Diabetes Association Diabetes Care. Oct, 2015 | Pubmed ID: 26404926 A Combination Hydrogel Microparticle-based Vaccine Prevents Type 1 Diabetes in Non-obese Diabetic Mice Scientific Reports. Aug, 2015 | Pubmed ID: 26279095 The Role for Gut Permeability in the Pathogenesis of Type 1 Diabetes--a Solid or Leaky Concept? Pediatric Diabetes. Nov, 2015 | Pubmed ID: 26269193 Acute Versus Progressive Onset of Diabetes in NOD Mice: Potential Implications for Therapeutic Interventions in Type 1 Diabetes Diabetes. Nov, 2015 | Pubmed ID: 26216853 Combination Therapy Reverses Hyperglycemia in NOD Mice With Established Type 1 Diabetes Diabetes. Nov, 2015 | Pubmed ID: 26185279 A Run on the Biobank: What Have We Learned About Type 1 Diabetes from the NPOD Tissue Repository? Current Opinion in Endocrinology, Diabetes, and Obesity. Aug, 2015 | Pubmed ID: 26087339 Current Concepts on the Pathogenesis of Type 1 Diabetes--considerations for Attempts to Prevent and Reverse the Disease Diabetes Care. Jun, 2015 | Pubmed ID: 25998290 Divergent Phenotypes of Human Regulatory T Cells Expressing the Receptors TIGIT and CD226 Journal of Immunology (Baltimore, Md. : 1950). Jul, 2015 | Pubmed ID: 25994968 A Combination Dual-sized Microparticle System Modulates Dendritic Cells and Prevents Type 1 Diabetes in Prediabetic NOD Mice Clinical Immunology (Orlando, Fla.). Sep, 2015 | Pubmed ID: 25842187 The Streetlight Effect in Type 1 Diabetes Diabetes. Apr, 2015 | Pubmed ID: 25805758 Beta-cell Destruction and Preservation in Childhood and Adult Onset Type 1 Diabetes Endocrine. Aug, 2015 | Pubmed ID: 25605478 Early Childhood Gut Microbiomes Show Strong Geographic Differences Among Subjects at High Risk for Type 1 Diabetes Diabetes Care. Feb, 2015 | Pubmed ID: 25519450 Anti-thymocyte Globulin/G-CSF Treatment Preserves β Cell Function in Patients with Established Type 1 Diabetes The Journal of Clinical Investigation. Jan, 2015 | Pubmed ID: 25500887 Bacteroides Dorei Dominates Gut Microbiome Prior to Autoimmunity in Finnish Children at High Risk for Type 1 Diabetes Frontiers in Microbiology. 2014 | Pubmed ID: 25540641 Stem Cells to Insulin Secreting Cells: Two Steps Forward and Now a Time to Pause? Cell Stem Cell. Nov, 2014 | Pubmed ID: 25517460 Losing a Grip on the Notion of β-cell Specificity for Immune Responses in Type 1 Diabetes: Can We Handle the Truth? Diabetes. Nov, 2014 | Pubmed ID: 25342726 New Insight on Human Type 1 Diabetes Biology: NPOD and NPOD-transplantation Current Diabetes Reports. Oct, 2014 | Pubmed ID: 25142715 Increased IFN-α-producing Plasmacytoid Dendritic Cells (pDCs) in Human Th1-mediated Type 1 Diabetes: PDCs Augment Th1 Responses Through IFN-α Production Journal of Immunology (Baltimore, Md. : 1950). Aug, 2014 | Pubmed ID: 24973447 Oral Delivery of Glutamic Acid Decarboxylase (GAD)-65 and IL10 by Lactococcus Lactis Reverses Diabetes in Recent-onset NOD Mice Diabetes. Aug, 2014 | Pubmed ID: 24677716 Pancreatic Biopsies in Type 1 Diabetes: Revisiting the Myth of Pandora's Box Diabetologia. Apr, 2014 | Pubmed ID: 24442510 The Juvenile Diabetes Research Foundation Network for Pancreatic Organ Donors with Diabetes (nPOD) Program: Goals, Operational Model and Emerging Findings Pediatric Diabetes. Feb, 2014 | Pubmed ID: 24325575 Type 1 Diabetes Lancet (London, England). Jan, 2014 | Pubmed ID: 23890997 Trying to Make a Difference for Those with Type 1 Diabetes: a Lesson in Patience As Well As a Willingness to Fail Mightily Expert Review of Endocrinology & Metabolism. Jul, 2013 | Pubmed ID: 30736146 Improving Diabetes Care in Resource-poor Countries: Challenges and Opportunities The Lancet. Diabetes & Endocrinology. Dec, 2013 | Pubmed ID: 24622408 GABA Regulates Both the Survival and Replication of Human Ss-cells Diabetes. Aug, 2013 | Pubmed ID: 23995958 Global Reality of Type 1 Diabetes Care in 2013 Diabetes Care. Sep, 2013 | Pubmed ID: 23970723 The Autoimmune Disease-associated SNP Rs917997 of IL18RAP Controls IFNγ Production by PBMC Journal of Autoimmunity. Aug, 2013 | Pubmed ID: 23891168 Inhibition of VEGFR-2 Reverses Type 1 Diabetes in NOD Mice by Abrogating Insulitis and Restoring Islet Function Diabetes. Aug, 2013 | Pubmed ID: 23835340 Autologous Umbilical Cord Blood Infusion Followed by Oral Docosahexaenoic Acid and Vitamin D Supplementation for C-peptide Preservation in Children with Type 1 Diabetes Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation. Jul, 2013 | Pubmed ID: 23611977 The Granulocyte Colony Stimulating Factor Pathway Regulates Autoantibody Production in a Murine Induced Model of Systemic Lupus Erythematosus Arthritis Research & Therapy. Apr, 2013 | Pubmed ID: 23566364 Serum Proteomics Reveals Systemic Dysregulation of Innate Immunity in Type 1 Diabetes The Journal of Experimental Medicine. Jan, 2013 | Pubmed ID: 23277452 Recent Lessons Learned from Prevention and Recent-onset Type 1 Diabetes Immunotherapy Trials Diabetes. Jan, 2013 | Pubmed ID: 23258904 Immune Modulation of Effector CD4+ and Regulatory T Cell Function by Sorafenib in Patients with Hepatocellular Carcinoma Cancer Immunology, Immunotherapy : CII. Apr, 2013 | Pubmed ID: 23223899 Anti-thymocyte Globulin (ATG) Differentially Depletes Naïve and Memory T Cells and Permits Memory-type Regulatory T Cells in Nonobese Diabetic Mice BMC Immunology. Dec, 2012 | Pubmed ID: 23237483 Pancreas Organ Weight in Individuals with Disease-associated Autoantibodies at Risk for Type 1 Diabetes JAMA. Dec, 2012 | Pubmed ID: 23232891 Serum Levels of Soluble CD25 As a Marker for Hepatocellular Carcinoma Oncology Letters. Oct, 2012 | Pubmed ID: 23205111 The Pathogenesis and Natural History of Type 1 Diabetes Cold Spring Harbor Perspectives in Medicine. Nov, 2012 | Pubmed ID: 23125199 In Vitro Generation of Functional Insulin-producing Cells from Human Bone Marrow-derived Stem Cells, but Long-term Culture Running Risk of Malignant Transformation American Journal of Stem Cells. Jun, 2012 | Pubmed ID: 22833839 Formation of a Human β-cell Population Within Pancreatic Islets is Set Early in Life The Journal of Clinical Endocrinology and Metabolism. Sep, 2012 | Pubmed ID: 22745242 Reversal of Autoimmune Diabetes by Restoration of Antigen-specific Tolerance Using Genetically Modified Lactococcus Lactis in Mice The Journal of Clinical Investigation. May, 2012 | Pubmed ID: 22484814 Demonstration of Islet-autoreactive CD8 T Cells in Insulitic Lesions from Recent Onset and Long-term Type 1 Diabetes Patients The Journal of Experimental Medicine. Jan, 2012 | Pubmed ID: 22213807 Central Role for Interleukin-2 in Type 1 Diabetes Diabetes. Jan, 2012 | Pubmed ID: 22187370 Gut Microbiome Metagenomics Analysis Suggests a Functional Model for the Development of Autoimmunity for Type 1 Diabetes PloS One. 2011 | Pubmed ID: 22043294 Structure-based Selection of Small Molecules to Alter Allele-specific MHC Class II Antigen Presentation Journal of Immunology (Baltimore, Md. : 1950). Dec, 2011 | Pubmed ID: 22043012 It's Time to Mow the GRAS in Type 1 Diabetes Diabetes. Nov, 2011 | Pubmed ID: 22025772 Autologous Umbilical Cord Blood Transfusion in Young Children with Type 1 Diabetes Fails to Preserve C-peptide Diabetes Care. Dec, 2011 | Pubmed ID: 22011412 Hyperglycemia-induced Proliferation of Adult Human Beta Cells Engrafted into Spontaneously Diabetic Immunodeficient NOD-Rag1null IL2rγnull Ins2Akita Mice Pancreas. Oct, 2011 | Pubmed ID: 21926555 Loss of Intra-islet CD20 Expression May Complicate Efficacy of B-cell-directed Type 1 Diabetes Therapies Diabetes. Nov, 2011 | Pubmed ID: 21926271 Evaluating Preclinical Efficacy Science Translational Medicine. Aug, 2011 | Pubmed ID: 21849661 B Cells Enhance Early Innate Immune Responses During Bacterial Sepsis The Journal of Experimental Medicine. Aug, 2011 | Pubmed ID: 21746813 Progressive Erosion of β-cell Function Precedes the Onset of Hyperglycemia in the NOD Mouse Model of Type 1 Diabetes Diabetes. Aug, 2011 | Pubmed ID: 21659497 How Does Type 1 Diabetes Develop?: the Notion of Homicide or β-cell Suicide Revisited Diabetes. May, 2011 | Pubmed ID: 21525508 Multimodality Imaging of β-cells in Mouse Models of Type 1 and 2 Diabetes Diabetes. May, 2011 | Pubmed ID: 21441442 Persistence is the Twin Sister of Excellence: an Important Lesson for Attempts to Prevent and Reverse Type 1 Diabetes Diabetes. Mar, 2011 | Pubmed ID: 21357468 Alpha-1 Antitrypsin Protein and Gene Therapies Decrease Autoimmunity and Delay Arthritis Development in Mouse Model Journal of Translational Medicine. 2011 | Pubmed ID: 21345239 Inhibition of Type 1 Diabetes Correlated to a Lactobacillus Johnsonii N6.2-mediated Th17 Bias Journal of Immunology (Baltimore, Md. : 1950). Mar, 2011 | Pubmed ID: 21317395 It's Time to Consider Changing the Rules: the Rationale for Rethinking Control Groups in Clinical Trials Aimed at Reversing Type 1 Diabetes Diabetes. Feb, 2011 | Pubmed ID: 21270247 Toward Defining the Autoimmune Microbiome for Type 1 Diabetes The ISME Journal. Jan, 2011 | Pubmed ID: 20613793 The Pancreas in Human Type 1 Diabetes Seminars in Immunopathology. Jan, 2011 | Pubmed ID: 20495921 Influence of Serum and Soluble CD25 (sCD25) on Regulatory and Effector T-cell Function in Hepatocellular Carcinoma Scandinavian Journal of Immunology. Oct, 2010 | Pubmed ID: 20883314 Efforts to Prevent and Halt Autoimmune Beta Cell Destruction Endocrinology and Metabolism Clinics of North America. Sep, 2010 | Pubmed ID: 20723818 Type I Diabetes. Preface Endocrinology and Metabolism Clinics of North America. Sep, 2010 | Pubmed ID: 20723814 Butyrate and Type 1 Diabetes Mellitus: Can We Fix the Intestinal Leak? Journal of Pediatric Gastroenterology and Nutrition. Oct, 2010 | Pubmed ID: 20706153 Human Antigen-specific Regulatory T Cells Generated by T Cell Receptor Gene Transfer PloS One. 2010 | Pubmed ID: 20668510 The Juvenile Diabetes Research Foundation at Forty: Updates of Research in Type 1 Diabetes Diabetes. Jul, 2010 | Pubmed ID: 20587801 Lactobacillus Johnsonii N6.2 Mitigates the Development of Type 1 Diabetes in BB-DP Rats PloS One. 2010 | Pubmed ID: 20463897 Hepatocellular Carcinoma Immunopathogenesis: Clinical Evidence for Global T Cell Defects and an Immunomodulatory Role for Soluble CD25 (sCD25) Digestive Diseases and Sciences. Feb, 2010 | Pubmed ID: 19714465 Exendin-4 Treatment of Nonobese Diabetic Mice Increases Beta-cell Proliferation and Fractional Insulin Reactive Area Journal of Diabetes and Its Complications. May-Jun, 2010 | Pubmed ID: 19217320 Influence of Membrane CD25 Stability on T Lymphocyte Activity: Implications for Immunoregulation PloS One. 2009 | Pubmed ID: 19956753 Autologous Umbilical Cord Blood Transfusion in Very Young Children with Type 1 Diabetes Diabetes Care. Nov, 2009 | Pubmed ID: 19875605 The Road Not Taken: a Path to Curing Type 1 Diabetes? European Journal of Immunology. Aug, 2009 | Pubmed ID: 19672902 Immune Depletion with Cellular Mobilization Imparts Immunoregulation and Reverses Autoimmune Diabetes in Nonobese Diabetic Mice Diabetes. Oct, 2009 | Pubmed ID: 19628781 The Pancreas in Human Type 1 Diabetes: Providing New Answers to Age-old Questions Current Opinion in Endocrinology, Diabetes, and Obesity. Aug, 2009 | Pubmed ID: 19502978 Influence of Fecal Sample Storage on Bacterial Community Diversity The Open Microbiology Journal. 2009 | Pubmed ID: 19440250 Rabbit Polyclonal Mouse Antithymocyte Globulin Administration Alters Dendritic Cell Profile and Function in NOD Mice to Suppress Diabetogenic Responses Journal of Immunology (Baltimore, Md. : 1950). Apr, 2009 | Pubmed ID: 19342635 Lowering Blood Pressure Blocks Mesangiolysis and Mesangial Nodules, but Not Tubulointerstitial Injury, in Diabetic ENOS Knockout Mice The American Journal of Pathology. Apr, 2009 | Pubmed ID: 19246639 Culture-independent Identification of Gut Bacteria Correlated with the Onset of Diabetes in a Rat Model The ISME Journal. May, 2009 | Pubmed ID: 19225551 Journal of Immunology (Baltimore, Md. : 1950). Jan, 2009 | Pubmed ID: 19124749 Taking a Daily Vitamin to Prevent Type 1 Diabetes? Diabetes. Jan, 2009 | Pubmed ID: 19114727 Expansion of Human Regulatory T-cells from Patients with Type 1 Diabetes Diabetes. Mar, 2009 | Pubmed ID: 19074986 Murine Model for Cystic Fibrosis Bone Disease Demonstrates Osteopenia and Sex-related Differences in Bone Formation Pediatric Research. Mar, 2009 | Pubmed ID: 19047917 Exendin-4 Therapy in NOD Mice with New-onset Diabetes Increases Regulatory T Cell Frequency Annals of the New York Academy of Sciences. Dec, 2008 | Pubmed ID: 19120286 Annals of the New York Academy of Sciences. Dec, 2008 | Pubmed ID: 19120270 Annals of the New York Academy of Sciences. Dec, 2008 | Pubmed ID: 19120260 Connective Tissue Research. 2008 | Pubmed ID: 19085241 The "perfect Storm" for Type 1 Diabetes: the Complex Interplay Between Intestinal Microbiota, Gut Permeability, and Mucosal Immunity Diabetes. Oct, 2008 | Pubmed ID: 18820210 CFTR Mutations Impart Elevated Immune Reactivity in a Murine Model of Cystic Fibrosis Related Diabetes Cytokine. Oct, 2008 | Pubmed ID: 18778952 The Pivotal Role of VEGF on Glomerular Macrophage Infiltration in Advanced Diabetic Nephropathy Laboratory Investigation; a Journal of Technical Methods and Pathology. Sep, 2008 | Pubmed ID: 18607348 Suppression by CD4+CD25+ Regulatory T Cells is Dependent on Expression of Heme Oxygenase-1 in Antigen-presenting Cells The American Journal of Pathology. Jul, 2008 | Pubmed ID: 18511516 Autologous Umbilical Cord Blood Infusion for Type 1 Diabetes Experimental Hematology. Jun, 2008 | Pubmed ID: 18358588 A New Hu-PBL Model for the Study of Human Islet Alloreactivity Based on NOD-scid Mice Bearing a Targeted Mutation in the IL-2 Receptor Gamma Chain Gene Clinical Immunology (Orlando, Fla.). Mar, 2008 | Pubmed ID: 18096436 Neonatal Formula Feeding Leads to Immunological Alterations in an Animal Model of Type 1 Diabetes Pediatric Research. Mar, 2008 | Pubmed ID: 18091354 Reversal of Streptozotocin-induced Diabetes in Mice by Cellular Transduction with Recombinant Pancreatic Transcription Factor Pancreatic Duodenal Homeobox-1: a Novel Protein Transduction Domain-based Therapy Diabetes. Mar, 2008 | Pubmed ID: 18086901 Murine Antithymocyte Globulin Therapy Alters Disease Progression in NOD Mice by a Time-dependent Induction of Immunoregulation Diabetes. Feb, 2008 | Pubmed ID: 18039815 Assessing the in Vitro Suppressive Capacity of Regulatory T Cells Immunological Investigations. 2007 | Pubmed ID: 18161521 Novel Synthesis of Cerium Oxide Nanoparticles for Free Radical Scavenging Nanomedicine (London, England). Jun, 2007 | Pubmed ID: 17716177 Treatment with GITR Agonistic Antibody Corrects Adaptive Immune Dysfunction in Sepsis Blood. Nov, 2007 | Pubmed ID: 17690255 Immunology. Sep, 2007 | Pubmed ID: 17662044 MyD88-dependent Expansion of an Immature GR-1(+)CD11b(+) Population Induces T Cell Suppression and Th2 Polarization in Sepsis The Journal of Experimental Medicine. Jun, 2007 | Pubmed ID: 17548519 Annals of the New York Academy of Sciences. Apr, 2007 | Pubmed ID: 17376834 Diabetic Endothelial Nitric Oxide Synthase Knockout Mice Develop Advanced Diabetic Nephropathy Journal of the American Society of Nephrology : JASN. Feb, 2007 | Pubmed ID: 17202420 Annals of the New York Academy of Sciences. Sep, 2006 | Pubmed ID: 17119209 Increased Natural CD4+CD25+ Regulatory T Cells and Their Suppressor Activity Do Not Contribute to Mortality in Murine Polymicrobial Sepsis Journal of Immunology (Baltimore, Md. : 1950). Dec, 2006 | Pubmed ID: 17114466 Molecular Therapy : the Journal of the American Society of Gene Therapy. Dec, 2006 | Pubmed ID: 16982215 IL-10 Regulation of Lupus in the NZM2410 Murine Model Laboratory Investigation; a Journal of Technical Methods and Pathology. Nov, 2006 | Pubmed ID: 16924244 Autoantibody Markers for the Diagnosis and Prediction of Type 1 Diabetes Autoimmunity Reviews. Jul, 2006 | Pubmed ID: 16890898 Noninvasive Imaging of Islet Grafts Using Positron-emission Tomography Proceedings of the National Academy of Sciences of the United States of America. Jul, 2006 | Pubmed ID: 16868090 Cystic Fibrosis Transmembrane Conductance Regulator Deficiency Exacerbates Islet Cell Dysfunction After Beta-cell Injury Diabetes. Jul, 2006 | Pubmed ID: 16804061 Role of Pax4 in Pdx1-VP16-mediated Liver-to-endocrine Pancreas Transdifferentiation Laboratory Investigation; a Journal of Technical Methods and Pathology. Aug, 2006 | Pubmed ID: 16732298 Uncoupling of Vascular Endothelial Growth Factor with Nitric Oxide As a Mechanism for Diabetic Vasculopathy Journal of the American Society of Nephrology : JASN. Mar, 2006 | Pubmed ID: 16436494 Enhanced IgE Allergic Response to Aspergillus Fumigatus in CFTR-/- Mice Laboratory Investigation; a Journal of Technical Methods and Pathology. Feb, 2006 | Pubmed ID: 16424881 Gene. Mar, 2006 | Pubmed ID: 16412588 Efficient Delivery of SiRNA into Cytokine-stimulated Insulinoma Cells Silences Fas Expression and Inhibits Fas-mediated Apoptosis FEBS Letters. Jan, 2006 | Pubmed ID: 16412430 Diabetes. Jan, 2006 | Pubmed ID: 16380490 Pediatric Diabetes. Dec, 2005 | Pubmed ID: 16390385 Type 1 Diabetes Mellitus: Etiology, Presentation, and Management Pediatric Clinics of North America. Dec, 2005 | Pubmed ID: 16301083 Inhalation Toxicology. Dec, 2005 | Pubmed ID: 16282156 IL-10 Suppresses Chemokines, Inflammation, and Fibrosis in a Model of Chronic Renal Disease Journal of the American Society of Nephrology : JASN. Dec, 2005 | Pubmed ID: 16251240 Glucose Transporter-2 (GLUT2) Promoter Mediated Transgenic Insulin Production Reduces Hyperglycemia in Diabetic Mice FEBS Letters. Oct, 2005 | Pubmed ID: 16223491 Systemic Overexpression of Interleukin-10 Fails to Protect Allogeneic Islet Transplants in Nonobese Diabetic Mice Transplantation. Aug, 2005 | Pubmed ID: 16123729 Diabetes. Sep, 2005 | Pubmed ID: 16123339 A Comprehensive Review of Interventions in the NOD Mouse and Implications for Translation Immunity. Aug, 2005 | Pubmed ID: 16111631 Localized Gene Expression Following Administration of Adeno-associated Viral Vectors Via Pancreatic Ducts Molecular Therapy : the Journal of the American Society of Gene Therapy. Sep, 2005 | Pubmed ID: 15979413 Biochemical and Biophysical Research Communications. Jun, 2005 | Pubmed ID: 15882999 Interleukin 10 Attenuates Neointimal Proliferation and Inflammation in Aortic Allografts by a Heme Oxygenase-dependent Pathway Proceedings of the National Academy of Sciences of the United States of America. May, 2005 | Pubmed ID: 15878989 Functional Defects and the Influence of Age on the Frequency of CD4+ CD25+ T-cells in Type 1 Diabetes Diabetes. May, 2005 | Pubmed ID: 15855327 ADA Outstanding Scientific Achievement Lecture 2004. Thirty Years of Investigating the Autoimmune Basis for Type 1 Diabetes: Why Can't We Prevent or Reverse This Disease? Diabetes. May, 2005 | Pubmed ID: 15855308 An Integral Role for Heme Oxygenase-1 and Carbon Monoxide in Maintaining Peripheral Tolerance by CD4+CD25+ Regulatory T Cells Journal of Immunology (Baltimore, Md. : 1950). May, 2005 | Pubmed ID: 15843512 Changes in Hippocampal IL-15, Related Cytokines, and Neurogenesis in IL-2 Deficient Mice Brain Research. Apr, 2005 | Pubmed ID: 15829231 Efficient Transduction of Vascular Endothelial Cells with Recombinant Adeno-associated Virus Serotype 1 and 5 Vectors Human Gene Therapy. Feb, 2005 | Pubmed ID: 15761263 Diabetes Acceleration or Prevention by a Coxsackievirus B4 Infection: Critical Requirements for Both Interleukin-4 and Gamma Interferon Journal of Virology. Jan, 2005 | Pubmed ID: 15613333 American Journal of Industrial Medicine. Dec, 2004 | Pubmed ID: 15551364 Heme Oxygenase-1 Modulates Early Inflammatory Responses: Evidence from the Heme Oxygenase-1-deficient Mouse The American Journal of Pathology. Sep, 2004 | Pubmed ID: 15331427 In Vivo and in Vitro Characterization of Insulin-producing Cells Obtained from Murine Bone Marrow Diabetes. Jul, 2004 | Pubmed ID: 15220196 Timing of Initial Cereal Exposure in Infancy and Risk of Islet Autoimmunity The Journal of Pediatrics. May, 2004 | Pubmed ID: 15152374 Molecular Therapy : the Journal of the American Society of Gene Therapy. Mar, 2004 | Pubmed ID: 15006610 Why Can't We Prevent Type 1 Diabetes?: Maybe It's Time to Try a Different Combination Diabetes Care. Dec, 2003 | Pubmed ID: 14633822 American Journal of Industrial Medicine. Sep, 2003 | Pubmed ID: 12929149 Systemic Overexpression of IL-10 Induces CD4+CD25+ Cell Populations in Vivo and Ameliorates Type 1 Diabetes in Nonobese Diabetic Mice in a Dose-dependent Fashion Journal of Immunology (Baltimore, Md. : 1950). Sep, 2003 | Pubmed ID: 12928371 Microbiology (Reading, England). Jun, 2003 | Pubmed ID: 12777499 Journal of Autoimmunity. May, 2003 | Pubmed ID: 12753809 Gene Delivery in Renal Tubular Epithelial Cells Using Recombinant Adeno-associated Viral Vectors Journal of the American Society of Nephrology : JASN. Apr, 2003 | Pubmed ID: 12660329 Adeno-associated Virus-mediated IL-10 Gene Therapy Inhibits Diabetes Recurrence in Syngeneic Islet Cell Transplantation of NOD Mice Diabetes. Mar, 2003 | Pubmed ID: 12606512 Matrix Biology : Journal of the International Society for Matrix Biology. Dec, 2002 | Pubmed ID: 12524049 Fatal Attraction: Chemokines and Type 1 Diabetes The Journal of Clinical Investigation. Dec, 2002 | Pubmed ID: 12464665 Adeno-associated Virus Transduction of Islets with Interleukin-4 Results in Impaired Metabolic Function in Syngeneic Marginal Islet Mass Transplantation Transplantation. Oct, 2002 | Pubmed ID: 12438968 Microbiology (Reading, England). Apr, 2002 | Pubmed ID: 11932443 Adeno-associated Virus Vector-mediated IL-10 Gene Delivery Prevents Type 1 Diabetes in NOD Mice Proceedings of the National Academy of Sciences of the United States of America. Nov, 2001 | Pubmed ID: 11717448 Heterophile Antibodies Segregate in Families and Are Associated with Protection from Type 1 Diabetes Proceedings of the National Academy of Sciences of the United States of America. Jul, 1999 | Pubmed ID: 10393957 Canlı Pankreas Doku Dilimlerinde Adacık fonksiyonu ve Adacık-İmmün Hücre Etkileşimlerinin Gözlemlenmesi Mollie K. Huber1, Denise M. Drotar2,3,4, Helmut Hiller1, Maria L. Beery1, Paul Joseph1, Irina Kusmartseva1, Stephan Speier2,3,4, Mark A. Atkinson1, Clayton E. Mathews1, Edward A. Phelps5 1Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, 2Paul Langerhans Institute Dresden (PLID) of the Helmholtz Zentrum München at the University Clinic Carl Gustav Carus of Technische Universität Dresden, 3Institute of Physiology, Faculty of Medicine, Technische Universität Dresden, 4German Center for Diabetes Research (DZD), 5J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida JoVE 62207 Immunology and Infection İnsan Pankreas için Toplama Protokolü Martha L. Campbell-Thompson1, Emily L. Montgomery1, Robin M. Foss1, Kerwin M. Kolheffer1, Gerald Phipps1, Lynda Schneider1, Mark A. Atkinson1 1Department of Pathology, Immunology, and Laboratory Medicine, University of Florida JoVE 4039 Medicine
Canlı Pankreas Doku Dilimlerinde Adacık fonksiyonu ve Adacık-İmmün Hücre Etkileşimlerinin Gözlemlenmesi Mollie K. Huber1, Denise M. Drotar2,3,4, Helmut Hiller1, Maria L. Beery1, Paul Joseph1, Irina Kusmartseva1, Stephan Speier2,3,4, Mark A. Atkinson1, Clayton E. Mathews1, Edward A. Phelps5 1Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, 2Paul Langerhans Institute Dresden (PLID) of the Helmholtz Zentrum München at the University Clinic Carl Gustav Carus of Technische Universität Dresden, 3Institute of Physiology, Faculty of Medicine, Technische Universität Dresden, 4German Center for Diabetes Research (DZD), 5J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida JoVE 62207 Immunology and Infection
İnsan Pankreas için Toplama Protokolü Martha L. Campbell-Thompson1, Emily L. Montgomery1, Robin M. Foss1, Kerwin M. Kolheffer1, Gerald Phipps1, Lynda Schneider1, Mark A. Atkinson1 1Department of Pathology, Immunology, and Laboratory Medicine, University of Florida JoVE 4039 Medicine