Paul Gadue Center for Cellular and Molecular Therapeutics The Children's Hospital of Philadelphia Biography Publications Institution JoVE Articles Paul Gadue has not added a biography. If you are Paul Gadue and would like to personalize this page please email our Author Liaison for assistance. Publications Modeling Monogenic Diabetes Using Human ESCs Reveals Developmental and Metabolic Deficiencies Caused by Mutations in HNF1A Cell Stem Cell. Aug, 2019 | Pubmed ID: 31374199 Generation of Spinocerebellar Ataxia Type 2 Induced Pluripotent Stem Cell Lines, CHOPi002-A and CHOPi003-A, from Patients with Abnormal CAG Repeats in the Coding Region of the ATXN2 Gene Stem Cell Research. 01, 2019 | Pubmed ID: 30611021 Highly Efficient CRISPR-Cas9-Mediated Genome Editing in Human Pluripotent Stem Cells Current Protocols in Stem Cell Biology. 02, 2019 | Pubmed ID: 30358158 Generation of a Human Juvenile Myelomonocytic Leukemia IPSC Line, CHOPi001-A, with a Mutation in CBL Stem Cell Research. 08, 2018 | Pubmed ID: 30096712 GATA6 Suppression Enhances Lung Specification from Human Pluripotent Stem Cells The Journal of Clinical Investigation. 07, 2018 | Pubmed ID: 29889101 Exploring the Interaction Between EIF2α Dysregulation, Acute Endoplasmic Reticulum Stress and DYT1 Dystonia in the Mammalian Brain Neuroscience. 02, 2018 | Pubmed ID: 29289717 Induced Pluripotent Stem Cell-Derived Megakaryocytes and Platelets for Disease Modeling and Future Clinical Applications Arteriosclerosis, Thrombosis, and Vascular Biology. 11, 2017 | Pubmed ID: 28982668 GATA6 Plays an Important Role in the Induction of Human Definitive Endoderm, Development of the Pancreas, and Functionality of Pancreatic β Cells Stem Cell Reports. 03, 2017 | Pubmed ID: 28196690 Generation of Human Control IPS Cell Line CHOPWT10 from Healthy Adult Peripheral Blood Mononuclear Cells Stem Cell Research. Mar, 2016 | Pubmed ID: 27345999 Generation of Hermansky Pudlak Syndrome Type 2 (HPS2) Induced Pluripotent Stem Cells (iPSCs) Stem Cell Research. Mar, 2016 | Pubmed ID: 27345985 Generation of Hermansky-Pudlak Syndrome Type 1 (HPS1) Induced Pluripotent Stem Cells (iPSCs) Stem Cell Research. Mar, 2016 | Pubmed ID: 27345974 Generation of Human Control IPS Cell Line CHOPWT9 from Healthy Adult Peripheral Blood Mononuclear Cells Stem Cell Research. Jan, 2016 | Pubmed ID: 27345777 A Doxycycline-Inducible System for Genetic Correction of IPSC Disease Models Methods in Molecular Biology (Clifton, N.J.). 2016 | Pubmed ID: 25630922 Generation of Poikiloderma with Neutropenia (PN) Induced Pluripotent Stem Cells (iPSCs) Stem Cell Research. Nov, 2015 | Pubmed ID: 26987923 OCT4 Coordinates with WNT Signaling to Pre-pattern Chromatin at the SOX17 Locus During Human ES Cell Differentiation into Definitive Endoderm Stem Cell Reports. Oct, 2015 | Pubmed ID: 26411902 Inducible Gata1 Suppression Expands Megakaryocyte-erythroid Progenitors from Embryonic Stem Cells The Journal of Clinical Investigation. Jun, 2015 | Pubmed ID: 25961454 Comparative Analysis of Human Ex Vivo-generated Platelets Vs Megakaryocyte-generated Platelets in Mice: a Cautionary Tale Blood. Jun, 2015 | Pubmed ID: 25852052 Emergence of a Stage-dependent Human Liver Disease Signature with Directed Differentiation of Alpha-1 Antitrypsin-deficient IPS Cells Stem Cell Reports. May, 2015 | Pubmed ID: 25843048 Pluripotent Stem Cells Reveal Erythroid-specific Activities of the GATA1 N-terminus The Journal of Clinical Investigation. Mar, 2015 | Pubmed ID: 25621499 Hematopoietic Differentiation of Pluripotent Stem Cells in Culture Methods in Molecular Biology (Clifton, N.J.). 2014 | Pubmed ID: 25062629 Utilization of the AAVS1 Safe Harbor Locus for Hematopoietic Specific Transgene Expression and Gene Knockdown in Human ES Cells Stem Cell Research. May, 2014 | Pubmed ID: 24631742 The Negative Impact of Wnt Signaling on Megakaryocyte and Primitive Erythroid Progenitors Derived from Human Embryonic Stem Cells Stem Cell Research. Mar, 2014 | Pubmed ID: 24412757 High-level Transgene Expression in Induced Pluripotent Stem Cell-derived Megakaryocytes: Correction of Glanzmann Thrombasthenia Blood. Jan, 2014 | Pubmed ID: 24335497 Clonal Genetic and Hematopoietic Heterogeneity Among Human-induced Pluripotent Stem Cell Lines Blood. Sep, 2013 | Pubmed ID: 23940280 Ribosomal and Hematopoietic Defects in Induced Pluripotent Stem Cells Derived from Diamond Blackfan Anemia Patients Blood. Aug, 2013 | Pubmed ID: 23744582 AAV-mediated Gene Therapy for Choroideremia: Preclinical Studies in Personalized Models PloS One. 2013 | Pubmed ID: 23667438 Trisomy 21-associated Defects in Human Primitive Hematopoiesis Revealed Through Induced Pluripotent Stem Cells Proceedings of the National Academy of Sciences of the United States of America. Oct, 2012 | Pubmed ID: 23045704 하답니다 Endodermal 조상 선 인간의 Pluripotent 줄기 세포에서 생성 된 Cell Stem Cell. Apr, 2012 | Pubmed ID: 22482503 인간 배아 줄기 세포의 분화 Embryoid 본문에 대 한 높은 처리 심사 분석 결과 Current Protocols in Stem Cell Biology. Mar, 2012 | Pubmed ID: 22415836 내 피 세포 틈새 Wnt 및 노치의 듀얼 억압을 통해 간장 사양 유도 신호 Stem Cells (Dayton, Ohio). Feb, 2011 | Pubmed ID: 21732480 마우스 ES와 IPS 세포 찍힌된 유전자의 차이도 불구 하 고 비슷한 확실 한 Endoderm를 형성할 수 있습니다 The Journal of Clinical Investigation. Jun, 2011 | Pubmed ID: 21537085 높은 처리량 다중화 인간 배아 줄기 세포의 분화 혈 청 무료 프로토콜을 최적화 하기 위한 심사 분석 결과 Stem Cell Research. Mar, 2011 | Pubmed ID: 21169079 유도 만능 줄기 세포에서 간 재생입니다 Molecular Therapy : the Journal of the American Society of Gene Therapy. Dec, 2010 | Pubmed ID: 21119691 Transgene 무료 폐 질환 관련 인간 유도 만능 줄기 세포 단일 Excisable Lentiviral 줄기 세포 카세트를 사용 하 여 생성 합니다 Stem Cells (Dayton, Ohio). Oct, 2010 | Pubmed ID: 20715179 Transcriptional 능력 및 배아 및 유도 만능 줄기 세포에서 정의 된 전사 인자에 의해 조직 관련 증강의 활성 표시 Genes & Development. Dec, 2009 | Pubmed ID: 20008934 줄기 세포는 노른자위 Sac 조 사람만 Blood. Aug, 2009 | Pubmed ID: 19696206 세포 표면 분자 초기 마우스 Endoderm에서 표현에 대 한 특정 단일 클론 항 체의 생성 Stem Cells (Dayton, Ohio). Sep, 2009 | Pubmed ID: 19522011 표 피 세포를 프로그래밍 레 브 Nature Biotechnology. Nov, 2008 | Pubmed ID: 18997762 마비는 Hemangioblast에서 기본 Erythropoietic 사양 변조 Wnt 노치 사이의 상호 작용을 중재 Development (Cambridge, England). Oct, 2008 | Pubmed ID: 18799543 Wnt, Activin, 및 BMP 신호 조절 혈액을 배아 줄기 세포 로부터 발달 통로에 별도 단계 Cell Stem Cell. Jan, 2008 | Pubmed ID: 18371422 식별 및 인간 배아 줄기 세포에서 ROSA26 로커 스의 대상으로 합니다 Nature Biotechnology. Dec, 2007 | Pubmed ID: 18037879 BMP-4는 마우스 배아 줄기 세포 유래 최종 Endoderm 간장 사양이 필요 합니다 Nature Biotechnology. Nov, 2006 | Pubmed ID: 17086172 Wnt 및 TGF-베타 신호는 배아 줄기 세포를 사용 하 여 기본 조 흔 형성 체 외 모델 유도 대 한 필요 합니다 Proceedings of the National Academy of Sciences of the United States of America. Nov, 2006 | Pubmed ID: 17077151 미 발달 줄기 세포에서 세균 층 유도입니다 Experimental Hematology. Sep, 2005 | Pubmed ID: 16140142 TCR에 의해 Fyn 돌연변이 생쥐에서 NK T 복원 셀 개발 초기 NK T 셀 Ontogeny 동안 Fyn에 대 한 요구 사항을 보여준다 Journal of Immunology (Baltimore, Md. : 1950). May, 2004 | Pubmed ID: 15128794 메 르 수용 체 티로신 키 니 아 제: 표현과 함수 타고 난 면제의 역할을 제안 합니다 European Journal of Immunology. Aug, 2003 | Pubmed ID: 12884290 NK T 세포 선구자 차동 Cytokine 규정 전시 및 효율적인 성숙 Itk 필요 Journal of Immunology (Baltimore, Md. : 1950). Sep, 2002 | Pubmed ID: 12193707 인간 다능성 줄기 세포에서 CRISPR-CAS9를 사용하여 정의된 게놈 수정 생성 Fabian L. Cardenas-Diaz*1, Jean Ann Maguire*1, Paul Gadue1,2,3, Deborah L. French1,2,3 1Center for Cellular and Molecular Therapeutics, The Children's Hospital of Philadelphia, 2Department of Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia, 3Department of Pathology and Laboratory Medicine, University of Pennsylvania JoVE 60085 Genetics STEMCCA Lentiviral 벡터를 사용하여 말초 혈에서 인간 유도 만능 줄기 세포의 생성 Andreia Gianotti Sommer1, Sarah S. Rozelle1, Spencer Sullivan2, Jason A. Mills3, Seon-Mi Park1, Brenden W. Smith1, Amulya M. Iyer1, Deborah L. French3, Darrell N. Kotton1, Paul Gadue3, George J. Murphy1, Gustavo Mostoslavsky1 1Center for Regenerative Medicine (CReM), Boston University School of Medicine, 2Department of Hematology, Children's Hospital of Philadelphia, 3Center for Cellular and Molecular Therapeutics, Children's Hospital of Philadelphia JoVE 4327 Biology
인간 다능성 줄기 세포에서 CRISPR-CAS9를 사용하여 정의된 게놈 수정 생성 Fabian L. Cardenas-Diaz*1, Jean Ann Maguire*1, Paul Gadue1,2,3, Deborah L. French1,2,3 1Center for Cellular and Molecular Therapeutics, The Children's Hospital of Philadelphia, 2Department of Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia, 3Department of Pathology and Laboratory Medicine, University of Pennsylvania JoVE 60085 Genetics
STEMCCA Lentiviral 벡터를 사용하여 말초 혈에서 인간 유도 만능 줄기 세포의 생성 Andreia Gianotti Sommer1, Sarah S. Rozelle1, Spencer Sullivan2, Jason A. Mills3, Seon-Mi Park1, Brenden W. Smith1, Amulya M. Iyer1, Deborah L. French3, Darrell N. Kotton1, Paul Gadue3, George J. Murphy1, Gustavo Mostoslavsky1 1Center for Regenerative Medicine (CReM), Boston University School of Medicine, 2Department of Hematology, Children's Hospital of Philadelphia, 3Center for Cellular and Molecular Therapeutics, Children's Hospital of Philadelphia JoVE 4327 Biology