Peter Cherepanov Chromatin Structure and Mobile DNA The Francis Crick Institute Biography Publications Institution JoVE Articles Peter Cherepanov has not added a biography. If you are Peter Cherepanov and would like to personalize this page please email our Author Liaison for assistance. Publications Cryo-EM Reveals a Novel Octameric Integrase Structure for Betaretroviral Intasome Function Nature. Feb, 2016 | Pubmed ID: 26887496 HIV-1 Integrase Strand Transfer Inhibitors with Reduced Susceptibility to Drug Resistant Mutant Integrases ACS Chemical Biology. Feb, 2016 | Pubmed ID: 26808478 Structural Basis for Retroviral Integration into Nucleosomes Nature. Jul, 2015 | Pubmed ID: 26061770 Key Determinants of Target DNA Recognition by Retroviral Intasomes Retrovirology. 2015 | Pubmed ID: 25924943 Retroviral Integrase Structure and DNA Recombination Mechanism Microbiology Spectrum. Dec, 2014 | Pubmed ID: 26104441 Retroviral Integrase Structure and DNA Recombination Mechanism Microbiology Spectrum. 2014 | Pubmed ID: 25705574 Efficient Transduction of LEDGF/p75 Mutant Cells by Gain-of-Function HIV-1 Integrase Mutant Viruses Molecular Therapy. Methods & Clinical Development. Jan, 2014 | Pubmed ID: 25383358 Integrase Residues That Determine Nucleotide Preferences at Sites of HIV-1 Integration: Implications for the Mechanism of Target DNA Binding Nucleic Acids Research. Apr, 2014 | Pubmed ID: 24520116 Structural Basis for Nuclear Import of Splicing Factors by Human Transportin 3 Proceedings of the National Academy of Sciences of the United States of America. Feb, 2014 | Pubmed ID: 24449914 Bromo- and Extraterminal Domain Chromatin Regulators Serve As Cofactors for Murine Leukemia Virus Integration Journal of Virology. Dec, 2013 | Pubmed ID: 24049186 Activities, Crystal Structures, and Molecular Dynamics of Dihydro-1H-isoindole Derivatives, Inhibitors of HIV-1 Integrase ACS Chemical Biology. Jan, 2013 | Pubmed ID: 23075516 Centralspindlin Links the Mitotic Spindle to the Plasma Membrane During Cytokinesis Nature. Dec, 2012 | Pubmed ID: 23235882 人間の CDC7 キナーゼとそのアクティベーター DBF4 の複合体の結晶構造。 Nature Structural & Molecular Biology. Nov, 2012 | Pubmed ID: 23064647 HRP2 Determines the Efficiency and Specificity of HIV-1 Integration in LEDGF/p75 Knockout Cells but Does Not Contribute to the Antiviral Activity of a Potent LEDGF/p75-binding Site Integrase Inhibitor Nucleic Acids Research. Dec, 2012 | Pubmed ID: 23042676 Solution Conformations of Prototype Foamy Virus Integrase and Its Stable Synaptic Complex with U5 Viral DNA Structure (London, England : 1993). Nov, 2012 | Pubmed ID: 23000384 3'-processing and Strand Transfer Catalysed by Retroviral Integrase in Crystallo The EMBO Journal. Jun, 2012 | Pubmed ID: 22580823 The Structural Biology of HIV-1: Mechanistic and Therapeutic Insights Nature Reviews. Microbiology. Apr, 2012 | Pubmed ID: 22421880 Structural and Functional Analyses of the Second-generation Integrase Strand Transfer Inhibitor Dolutegravir (S/GSK1349572) Molecular Pharmacology. Oct, 2011 | Pubmed ID: 21719464 Structural Insights into the Retroviral DNA Integration Apparatus Current Opinion in Structural Biology. Apr, 2011 | Pubmed ID: 21277766 Structural Biology of Retroviral DNA Integration Virology. Mar, 2011 | Pubmed ID: 21216426 The Mechanism of Retroviral Integration from X-ray Structures of Its Key Intermediates Nature. Nov, 2010 | Pubmed ID: 21068843 Molecular Mechanisms of Retroviral Integrase Inhibition and the Evolution of Viral Resistance Proceedings of the National Academy of Sciences of the United States of America. Nov, 2010 | Pubmed ID: 21030679 Structure-based Modeling of the Functional HIV-1 Intasome and Its Inhibition Proceedings of the National Academy of Sciences of the United States of America. Sep, 2010 | Pubmed ID: 20733078 Integrase Illuminated EMBO Reports. May, 2010 | Pubmed ID: 20428106 Retroviral Intasome Assembly and Inhibition of DNA Strand Transfer Nature. Mar, 2010 | Pubmed ID: 20118915 Transcriptional Co-activator LEDGF Interacts with Cdc7-activator of S-phase Kinase (ASK) and Stimulates Its Enzymatic Activity The Journal of Biological Chemistry. Jan, 2010 | Pubmed ID: 19864417 The Interaction Between Lentiviral Integrase and LEDGF: Structural and Functional Insights Viruses. Dec, 2009 | Pubmed ID: 21994569 Application of General Formulas for the Correction of a Lattice-translocation Defect in Crystals of a Lentiviral Integrase in Complex with LEDGF Acta Crystallographica. Section D, Biological Crystallography. Sep, 2009 | Pubmed ID: 19690374 Structural Basis for Functional Tetramerization of Lentiviral Integrase PLoS Pathogens. Jul, 2009 | Pubmed ID: 19609359 The SET Complex Acts As a Barrier to Autointegration of HIV-1 PLoS Pathogens. Mar, 2009 | Pubmed ID: 19266025 HIV-1 Exploits Importin 7 to Maximize Nuclear Import of Its DNA Genome Retrovirology. 2009 | Pubmed ID: 19193229 A Novel Co-crystal Structure Affords the Design of Gain-of-function Lentiviral Integrase Mutants in the Presence of Modified PSIP1/LEDGF/p75 PLoS Pathogens. Jan, 2009 | Pubmed ID: 19132083 Functional and Structural Characterization of the Integrase from the Prototype Foamy Virus Nucleic Acids Research. Jan, 2009 | Pubmed ID: 19036793 The Lentiviral Integrase Binding Protein LEDGF/p75 and HIV-1 Replication PLoS Pathogens. Mar, 2008 | Pubmed ID: 18369482 LEDGF/p75 Functions Downstream from Preintegration Complex Formation to Effect Gene-specific HIV-1 Integration Genes & Development. Jul, 2007 | Pubmed ID: 17639082 LEDGF/p75 Interacts with Divergent Lentiviral Integrases and Modulates Their Enzymatic Activity in Vitro Nucleic Acids Research. 2007 | Pubmed ID: 17158150 Structure-based Mutagenesis of the Integrase-LEDGF/p75 Interface Uncouples a Strict Correlation Between in Vitro Protein Binding and HIV-1 Fitness Virology. Jan, 2007 | Pubmed ID: 16959283 Transcriptional Co-activator P75 Binds and Tethers the Myc-interacting Protein JPO2 to Chromatin Journal of Cell Science. Jun, 2006 | Pubmed ID: 16735438 A Tripartite DNA-binding Element, Comprised of the Nuclear Localization Signal and Two AT-hook Motifs, Mediates the Association of LEDGF/p75 with Chromatin in Vivo Nucleic Acids Research. 2006 | Pubmed ID: 16549878 Structural Basis for the Recognition Between HIV-1 Integrase and Transcriptional Coactivator P75 Proceedings of the National Academy of Sciences of the United States of America. Nov, 2005 | Pubmed ID: 16260736 Lys-34, Dispensable for Integrase Catalysis, is Required for Preintegration Complex Function and Human Immunodeficiency Virus Type 1 Replication Journal of Virology. Oct, 2005 | Pubmed ID: 16160186 Env とギャグの遺伝子の突然変異によるキメラ ウイルス技術に裏付け Polysulfonic デンドリマー SPL2923、HIV 1 抵抗性が必要です。 Antiviral Chemistry & Chemotherapy. 2005 | Pubmed ID: 16130523 Solution Structure of the HIV-1 Integrase-binding Domain in LEDGF/p75 Nature Structural & Molecular Biology. Jun, 2005 | Pubmed ID: 15895093 Class II Integrase Mutants with Changes in Putative Nuclear Localization Signals Are Primarily Blocked at a Postnuclear Entry Step of Human Immunodeficiency Virus Type 1 Replication Journal of Virology. Dec, 2004 | Pubmed ID: 15542626 Identification of an Evolutionarily Conserved Domain in Human Lens Epithelium-derived Growth Factor/transcriptional Co-activator P75 (LEDGF/p75) That Binds HIV-1 Integrase The Journal of Biological Chemistry. Nov, 2004 | Pubmed ID: 15371438 同定および機能の核局在シグナル 1 HIV インテグラーゼ Interactor LEDGF/p75 で。 The Journal of Biological Chemistry. Aug, 2004 | Pubmed ID: 15163664 Hiv-1 インテグラーゼ CEM 細胞での発現 HIV-1 の複製を阻害します。 The Journal of Gene Medicine. Mar, 2004 | Pubmed ID: 15026988 LEDGF/p75 核と染色体 Hiv-1 インテグラーゼひと細胞での対象化に不可欠であります。 The Journal of Biological Chemistry. Aug, 2003 | Pubmed ID: 12796494 PH6 Antigen of Yersinia Pestis Interacts with Plasma Lipoproteins and Cell Membranes Journal of Lipid Research. Feb, 2003 | Pubmed ID: 12576514 Hiv-1 インテグラーゼ フォーム テトラマー ・ アソシエイツ LEDGF/p75 蛋白のひと細胞に安定。 にします。 The Journal of Biological Chemistry. Jan, 2003 | Pubmed ID: 12407101 ひと免疫不全ウイルス エントリ阻害剤に対する感受性の評価のための Env のキメラ ウイルス技術 Antimicrobial Agents and Chemotherapy. Dec, 2002 | Pubmed ID: 12435701 HIV-1 の統合の本格的な阻害剤を求めて。 Antiviral Chemistry & Chemotherapy. Jan, 2002 | Pubmed ID: 12180645 培養細胞でのウイルスの複製をブロック HIV インテグラーゼ阻害剤の新しいクラス。 Current Biology : CB. Jul, 2002 | Pubmed ID: 12176326 Role of Yersinia Murine Toxin in Survival of Yersinia Pestis in the Midgut of the Flea Vector Science (New York, N.Y.). Apr, 2002 | Pubmed ID: 11976454 レトロウイルス統合サイトの増幅、次世代シーケンシング、およびゲノムDNAのマッピング Erik Serrao1, Peter Cherepanov2, Alan N. Engelman1 1Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, 2Chromatin Structure and Mobile DNA, The Francis Crick Institute Biology
レトロウイルス統合サイトの増幅、次世代シーケンシング、およびゲノムDNAのマッピング Erik Serrao1, Peter Cherepanov2, Alan N. Engelman1 1Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, 2Chromatin Structure and Mobile DNA, The Francis Crick Institute Biology